Astrocytes exhibit a large number of Gq G protein-coupled receptors (Gq GPCRs) linked to calcium mobilization from internal stores. While these receptors are activated by neurotransmitters released from presynaptic terminals, astrocytic Gq GPCR calcium signaling does not modulate hippocampal synaptic transmission and plasticity. The neurophysiological outcome of neuron-to-astrocyte Gq GPCR calcium signaling remains unknown.

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