Clyde W. Hodge

Clyde W. Hodge

 

Professor

Department of Psychiatry

Ph.D., Behavioral Psychology
Auburn University

Biosketch [.pdf]

Department of Psychiatry
Bowles Center for Alcohol Studies
Behavioral Pharmacology &
Pharmacogenomics Lab

Ph.D., Behavioral Psychology
Auburn University

Contact Information ->>

Research Interests

  • Discover the neural circuits and molecular mechanisms that mediate the reinforcing and pleasurable subjective effects of alcohol and other drugs
  • Identify the long-term effects of cocaine and alcohol abuse during adolescence
  • Identify novel neural targets and validate pharmacological compounds that may be used to treat problems associated with alcohol and drug abuse

Research Synopsis

Our studies have shown that the limbic system and extended amygdala regulate alcohol-seeking behavior and conditioned discriminative stimulus effects of alcohol. We established that neuropeptide-Y in the hypothalamus modulates excessive alcohol drinking similar to its role in obesity via the Y1 receptor, and that NPY-Y5 receptor blockade reduces the reinforcing effects of alcohol. Also, using gene knockout mice, we have shown that Protein Kinase C-ε regulates alcohol drinking, reinforcement, sensitivity, withdrawal, and mesolimbic dopamine release through enhancement of GABA-A receptor function. Other studies have shown that adolescent exposure to cocaine leads to enhanced vulnerability to the rewarding effects of cocaine during adulthood in mice via activation of the limbic system.

Publications

pubmed

Click above for PubMed publications.

Contact Information


Office Location:
1025A Thurston Bowles Bldg. 

Mailing Address:
CB # 7178
UNC-CH School of Medicine
Chapel Hill, NC 27599-7178

Office Phone: 919-843-4823
Lab Phone:
Fax: 919-966-5679
chodge[at]med.unc.edu

 

 

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