Klaus Hahn

Klaus M. Hahn

Ronald Thurman Distinguished Professor
Department of Pharmacology

Joint Professor
Division of Medicinal Chemistry & Natural Products
School of Pharmacy

Director, UNC-Olympus Imaging Center

Fellow, American Association for the
Advancement of Science (AAAS)

Ph.D., Chemistry
University of Virgina

Biosketch [.pdf]

Hahn Lab Website [hahnlab.com]

Contact Information ->>

Research Interests

  • Spatio-temporal dynamics of signaling networks in metastasis and immune cell interactions
  • Molecules for imaging and manipulation of protein activity in living cells and animals

Research Synopsis

Our lab focuses on two synergistic areas: development of proteins and small molecules to visualize and control protein activity in live cells and animals, and applying these tools to address basic questions re spatio-temporal control of signaling. Our biological studies center on the role of cytoskeletal and adhesion dynamics in signaling crosstalk, directed motility, and the role of immune cells in disease. We are extending our cell biology studies to examine metastasis and macrophage motility in 3D models and in vivo.

While addressing specific molecules for our biological studies, we have produced generally applicable approaches to visualize and control signaling. These include new fluorescent biosensor designs to quantify conformational changes of endogenous proteins, and biosensors based on engineered protein scaffolds for otherwise inaccessible molecules. We are developing fluorescent dyes for single molecule microscopy of protein conformational changes in vivo, and engineered domains that can be inserted into target proteins to control protein function using either light or small molecules. Other new methods selectively activate specific protein behaviors.

We greatly benefit from interactions with collaborators who focus on computational image analysis, modeling of signaling dynamics, and developing novel microscopes.

In case of broken links please go to hahnlab.com for Hahn lab website.

Recent Publications

Click here for complete list of published work (NCBI bibliography).


Contact Information

Office Location:
4043 Genetic Medicine

Mailing Address:
CB # 7365
UNC-CH School of Medicine
Chapel Hill, NC 27599-7365

Office Phone: 919-843-2775
Fax: 919-966-5640



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