Nicholas G. Brown

Research Interests

  • Cell cycle, mitosis, ubiquitin ligases, anaphase promoting complex

Research Synopsis 

The overarching goal of my research program is to understand the system of inter- and intra-molecular interactions that dynamically regulate the catalytic mechanisms of enzymes to precisely time the events of the cell cycle.  We employ a hybrid technological approach, including enzyme kinetics, mutagenesis, X-ray crystallography, NMR spectroscopy, and cryo-EM, to characterize these molecular machines.  Our results provide mechanistic insight into the cell cycle that will influence the drug design of cancer therapeutics.

 

 

Publications

 View complete list of published works in NCBI Library


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