• Dixit, V., and Juliano, R.L. (2008) Selective Killing of Smad4-Negative Tumor Cells Via A Designed Repressor Strategy. Mol Pharmacol [epub]. Abstract

  • Alam, M.R., Dixit, V., Kang H., Li, Z.B., Chen, X., Trejo, J., Fisher, M., and Juliano, R.L. (2008) Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res [epub]. Abstract

  • Healy, K.D., Hodgson, L., Kim, T.Y., SHutes, A., Maddileti, S., Juliano, R.L., Hahn, K.M., Harden, T.K., Bang, Y.J., and Der, C.J. (2008) DLC-1 suprresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog 47(5): 326-37. Abstract

  • Mikhailov, S.N., Bobkov, G.V., Brilliantov, K.V., Rozenski, J., Van Aerschot, A., Herdewijn, P., Fisher, M.H., and Juliano, R.L. (2008) 2'-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides. Nucleosides, Nucleotides, Nucleic Acids 26(10-12): 1509-12. Abstract

  • Juliano, R.L. (2007) Bugging Tumors to Put Drugs on Target. New Eng J Med 356(9): 954-955. Article

  • Nauwelaerts, K., Fisher, M., Freyen, M., Lescrinier, E., Aerschot, A. V., Xu, D., DeLong, R., Kang, H., Juliano, R.L., and Herdewijn, P. (2007) Structural characterization and biological evaluation of small intervering RNAs containing cyclohexenyl nucleosides. J Am Chem Soc 129(30): 9340-8. Abstract

  • Fisher, M., Abramov, M., Van Aerschot, A., Xu, D., Juliano, R.L., Herdewijn, P. (2007) Inhibition of MDR1 expression with altritol-modified siRNAs. Nuc Acid Res 35(4): 1064-74. Abstract

  • Juliano, R.L. Intracellular delivery of oligonucleotide conjugates and dendrimer complexes. (2006) Ann NY Acad Sci 1082: 18-26. Abstract

  • Reddig, P.J., and Juliano, R.L. (2005) Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev 24(3): 425-39, (review). Abstract

  • Kang, H., DeLong, R. Fisher, M.H., and Juliano, R.L. (2005) Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides. Pharm Res 22(12): 2099-106. Abstract

  • Xu, D., and Juliano, R.L. Epigenetic modulation of gene expression in mammalian cells. (2005) Crit Rev Eurkaryot Gene Expr 15(2): 93-101, (review). Abstract

  • Juliano, R.L. (2005) Peptide-oligonucleotide conjugates for the delivery of antisense and siRNA. Curr Opin Mol Ther 7(2): 132-6, (review). Abstract

  • Reddig, P.J., Xu, D., and Juliano, R.L.. (2005) Regulation of p21-activated kinase-independent Rac1 signal transduction by Nischarin. J Biol Chem 280(35): 30994-1002. Abstract

  • Edin, M.L., and Juliano, R.L. (2005) Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Mol Cell Biol 25(11): 4466-75. Abstract

  • Chaltin, P., Margineanu, A., Marchand, D., Van Aerschot, A., Rozenski, J., De Schryver, F., Herrmann, A., Mullen, K., Juliano, R., Fisher, M.H., Kang, H., De Feyter, S., and Herdewijn, P. (2005) Delivery of antisense oligonucleotides using cholesterol-modified sense dendrimers and cationic lipids. Bioconjug Chem 16(4): 827-36. Abstract

  • Xu D, McCarty D, Fernandes A, Fisher M, Samulski RJ, Juliano RL (2005). Delivery of MDR1 Small Interfering RNA by Self-Complementary Recombinant Adeno-Associated Virus Vector. Mol Ther 11: 523-30. Abstract

  • Juliano RL, Dixit VR, Kang H, Kim TY, Miyamoto Y, Xu D. (2005) Epigenetic manipulation of gene expression: a toolkit for cell biologists. J Cell Biol 169: 847-857. Abstract

  • Juliano RL, Reddig P, Alahari S, Edin M, Howe A, Aplin A (2004). Integrin regulation of cell signalling and motility. Biochem Soc Trans 32(Pt3): 443-6, (review). Abstract

  • Alahari SK and Nasrallah H. (2004) A membrane proximal region of the integrin alpha5 subunit is important for its interaction with Nischarin. Biochem J 377: 449-457. [PDF]

  • Astriab-Fisher A, Fisher M, Juliano RL, Herdewijn P. (2004) Increased uptake of antisense oligonucleotides by delivery as double stranded complexes. Biochem Pharmacol 68: 403-7.

  • Juliano RL, Reddig P, Alahari S, Edin M, Howe A, Aplin A. (2004) Integrin regulation of cell signalling and motility. Biochem Soc Trans 32(Pt3): 443-6, (review).

  • Kang H, Fisher MH, Xu D, Miyamoto YJ, Marchand A, Van Aerschot A, Herdewijn P, Juliano RL. (2004) Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides. Nucleic Acids Res 32: 4411-9.

  • Xu D, Kang H, Fisher M, Juliano RL. (2004) Strategies for the inhibition of MDR1 gene expression. Mol. Pharmacol 66(2): 1-8.

  • Alahari SK, Reddig P, and Juliano RL. (2004) The integrin binding protein nischarin Regulates cell migration by inhibiting PAK EMBO J 23: 2777-88.

  • Alahari SK. (2003) Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK. Exp Cell Res 288(2): 415-24. [PDF]

  • Falke D, Juliano RL. (2003) Selective gene regulation with designed transcription factors: implications for therapy. Curr Opin Mol Ther 5(2): 161-6, (review).

  • Falke D, Fisher M, Ye D, Juliano RL. (2003) Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene. Nucleic Acids Res. 31(3): e10.

  • Juliano R. (2003) Movin' on through with Cdc2. Nat Cell Biol 5(7): 589-590. [PDF]

  • Laakko T, Juliano RL. (2003) Adhesion regulation of stromal cell-derived factor-1 activation of ERK in lymphocytes by phosphatases. J Biol Chem 278(34): 31621-8. [PDF]

  • Xu D, Falke D, Juliano RL. (2003) P53-dependent cell killing by selective repression of thymidine kinase and reduced prodrug activation. Mol Pharmacol 64(2): 289-97. [PDF]

  • Aplin AE, Hogan BP, Tomeu J, Juliano RL. (2002) Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases. J Cell Sci 115(Pt 13): 2781-90.

  • Astriab-Fisher A, Sergueev D, Fisher M, Shaw BR, Juliano RL. (2002) Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions. Pharm Res. 19: 744-754. [PDF]

  • Howe AK, Hogan BP, Juliano RL. (2002) Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion. J Biol Chem 277(41): 38121-6. [PDF]

  • Juliano RL. (2002) Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Annu Rev Pharmacol Toxicol 42:283-323, (review). [PDF]

  • Xu D, Ye D, Fisher M, Juliano RL. (2002) Selective inhibition of P-glycoprotein expression in multidrug-resistant tumor cells by a designed transcriptional regulator. J Pharmacol Exp Ther 302(3): 963-71.

  • Ye D, Xu D, Singer AU, Juliano RL. Evaluation of strategies for the intracellular delivery of proteins. (2002) Pharm Res 19(9): 1302-9. [PDF]

  • Alahari, S.K.,: Mapping of the gene for Nischarin, a novel integrin binding protein, to chromosome 3 by fluorescence in situ hybridization (2001). Intl J Human Genetics 1: 271-274

  • Aplin, A.E., Stewart, S.A., Assoian, R.K., and Juliano, R.L. (2001). Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. J Cell Biol 153: 273-281. [PDF]

  • Fisher AA, Ye D, Sergueev DS, Fisher MH, Shaw BR, Juliano RL. (2001) Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis. J Biol Chem 277(25): 22980-4.

  • Howe, A.K. (2001). Cell adhesion regulates the interaction between Nck and p21-activated kinase. J Biol Chem 11: 737-744. [PDF]

  • Edin, M., Howe, A., Juliano, R. (2001) Inhibition of PKA blocks fibroblast migration in response to growth factors. Exp Cell Res 270: 214-222. [PDF]

  • Alahari, S.K., Lee, J.W., and Juliano, R.L. (2000). Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J Cell Biol 151: 1141-1154. [PDF]

  • Astriab-Fisher A, Sergueev DS, Fisher M, Shaw BR, Juliano RL. (2000) Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. Biochem Pharmacol 60(1):83-90.

  • Bartsevich VV, Juliano RL Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries. (2000) Mol Pharmacol 58(1):1-10.

  • Howe, A.K. and Juliano, R. L. (2000). Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nature Cell Biol 2: 593-600. [PDF]

  • Hughes J., Astriab A., Yoo H., Alahari S., Liang E., Sergueev D., Shaw B.R., and Juliano R.L. (2000). In vitro transport and delivery of antisense oligonucleotides.
    Meth Enzymol 313:342-358.

  • Juliano, R.L. and Yoo, H. (2000). Aspects of the transport and delivery of antisense oligonucleotides. Curr Opin Mol Ther 2: 297-303.

  • Lee, J.W. and Juliano, R.L. (2000). Alpha5-beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway. Mol Cell Biol 11: 1973-1987. [PDF]

  • Parise, L.V., Lee, J.W., and Juliano, R.L. (2000). New aspects of integrin signaling in cancer. Semin Cancer Biol 10: 407-414.

  • Short, S.M., Boyer, J.L., and Juliano, R.L. (2000). Integrins regulate the linkage between upstream and downstream events in G protein-coupled receptor signaling to mitogen-activated protein kinase. J Biol Chem 275: 12970-12977. [PDF]

  • Yoo, H. and Juliano, R.L. (2000). Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers. Nuc Acids Res 28: 4225-31.

  • Aplin, A. E., Short, S. M., and Juliano, R.L. (1999). Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains. J Biol Chem 274: 31223-28. [PDF]

  • Aplin, A. E., Howe, A. K. and Juliano, R. L. (1999). Cell adhesion molecules, signal transduction, and cell growth. Curr Opin Cell Biol 11: 737-744. [PDF]

  • Aplin, A. E. and Juliano, R. L. (1999). Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway. J Cell Sci 112: 695-706. [PDF]

  • DeLong, R. K., Yoo, H., Alahari, S. K., Fisher, M., Short, S. M., Kang, S. H., Kole, R., Janout, V., Regan, S. L. and Juliano, R. L. (1999). Novel cationic amphiphiles as delivery agents for antisense oligonucleotides. Nuc Acids Res 27: 3334-41.

  • Juliano, R. L., Alahari, S., Yoo, H., Kole, R. and Cho, M. (1999). Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides. Pharm Res 16: 494-502.[PDF]

  • Yoo, H., Sazani, P., and Juliano, R.L. (1999). PAMAM dendrimers as delivery agents for antisense oligonucleotides. Pharm Res 16: 1799-1804.

  • Alahari, S. K., DeLong, R., Fisher, M. H., Dean, N. M., Viliet, P. and Juliano, R. L. (1998). Novel chemically modified oligonucleotides provide potent inhibition of P-glycoprotein expression. J Pharm ExpTherap 286: 419-28.

  • Aplin, A. E., Howe, A., Alahari, S. K. and Juliano, R. L. (1998). Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev 50: 197-263. [PDF]

  • Howe, A., Aplin, A. E., Alahari, S. K. and Juliano, R. L. (1998). Integrin signaling and cell growth control. Curr Opin in Cell Biol 10: 220-31. [PDF]

  • Howe, A. K. and Juliano, R. L. (1998). Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade. J Biol Chem 273: 27268-74. [PDF]

  • Keely, P., Parise, L. and Juliano, R. (1998). Integrins and GTPases in tumour cell growth, motility and invasion. Trends Cell Biol 8: 101-6.

  • Short, S. M., Talbott, G. A. and Juliano, R. L. (1998). Integrin-mediated signaling events in human endothelial cells. Mol Biol Cell 9: 1969-80. [PDF]

  • Lin, T. H., Aplin, A. E., Shen, Y., Chen, Q., Schaller, M., Romer, L., Aukhil, I. and Juliano, R. L. (1997). Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J Cell Biol 136: 1385-95. [PDF]

  • Cheng, X., Boyer, J. L. and Juliano, R. L. (1997). Selection of peptides that functionally replace a zinc finger in the Sp1 transcription factor by using a yeast combinatorial library. Proc Natl Acad Sci USA 94: 14120-5.

  • Cheng, X., DeLong, R. K., Wickstrom, E., Kligshteyn, M., Demirdji, S. H., Caruthers, M. H. and Juliano, R. L. (1997). Interactions between single-stranded DNA binding protein and oligonucleotide analogs with different backbone chemistries. J Mol Recog 10: 101-7.

  • DeLong, R., Stephenson, K., Loftus, T., Fisher, M., Alahari, S., Nolting, A. and Juliano, R. L. (1997). Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery. J Pharmaceut Sci 86: 762-4.

  • DeLong, R. K., Nolting, A., Fisher, M., Chen, Q., Wickstrom, E., Kligshteyn, M., Demirdji, S., Caruthers, M. and Juliano, R. L. (1997). Comparative pharmacokinetics, tissue distribution, and tumor accumulation of phosphorothioate, phosphorodithioate, and methylphosphonate oligonucleotides in nude mice. Antisense Nu. Acid Drug Dev 7: 71-7.

  • Lin, T. H., Chen, Q., Howe, A. and Juliano, R. L. (1997). Cell anchorage permits efficient signal transduction between ras and its downstream kinases. J Biol Chem 272: 8849-52. [PDF]

  • Nolting, A., DeLong, R. K., Fisher, M. H., Wickstrom, E., Pollack, G. M., Juliano, R. L. and Brouwer, K. L. (1997). Hepatic distribution and clearance of antisense oligonucleotides in the isolated perfused rat liver. Pharmaceut Res14: 516-21.

  • Cho MJ, Juliano R. (1996) Macromolecular versus small-molecule therapeutics: drug discovery, development and clinical considerations. Trends Biotechnol 14(5): 153-158 .[PDF]

  • Alahari, S. K., Dean, N. M., Fisher, M. H., Delong, R., Manoharan, M., Tivel, K. L. and Juliano, R. L. (1996). Inhibition of expression of the multidrug resistance-associated P-glycoprotein of by phosphorothioate and 5' cholesterol-conjugated phosphorothioate antisense oligonucleotides. Mol Pharm 50: 808-19.

  • Chen, Q., Lin, T. H., Der, C. J. and Juliano, R. L. (1996). Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras. J Biol Chem 271: 18122-7.

  • Juliano, R. (1996). Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. Bioessays 18: 911-7.