Course Information

PHYI 202 - Introduction to Physiology (5)
(formerly PHYI 92)
Prerequisites: Chemistry 101 (011), Chemistry 102 (021) and Biology 252 (045)
[or Biochemistry 107 (007), Biochemistry 108 (008)] and Biology 252 (045) or equivalents.
A course in basic human physiology with an appreciation for its clinical application. Emphasis is on body fluids, various organ systems and their interrelationships. Required of all nursing students and available to other students by permission of the instructor. Five lecture hours per week. Spring semester only. Shea, staff.

PHYI 395 - Undergraduate Research in Physiology (1 - 3)
(formerly PHYI 98)
Prerequisites, Biology 11, 11L, Chemistry 11, 11L, an overall 3.0 GPA, and permission of the instructor. Directed readings or laboratory study on a selected topic. Final written report required in each term. At least three hours of independent work per week for each unit of credit. Fall, spring, and summer. Staff.

PHYI 625 - Stem Cell and Maturational Lineage Biology (4)
Course schedule/flyer
General lectures, analyses and discussions of primary literature on stem cell and lineage biology, and research seminars by leaders in the fields of stem cell and maturational lineage biology.  Themes to be presented include basic cell and molecular biological characterization of stem cells, regulation of self-replication versus lineage restriction and differentiation of cells, model systems used in studies of stem cells, and the relevance of it all to tissue formation, regeneration, disease states involving lineage-dependent pathogenic infections or mutation(s), and strategies for clinical therapies in regenerative medicine. In addition, there will be lectures on clinical and commercial programs involving stem cells. 
Fall. Reid, staff.

PHYI 701 - Laboratory Rotation (3)
(formerly PHYI 210)
Rotations in faculty laboratories introduce methods and techniques in physiology. Individual projects provide an opportunity to explore potential dissertation projects. Staff.

PHYI 703 - Molecular, Cellular and Integrative Physiology (3)
(formerly PHYI 125)
Molecular and cellular basis of organ system function and integration of the organ systems to maintain the normal state. The first block, available as a 1-credit module, covers electrical signaling and synaptic transmission in a manner suitable for the student who wants a solid understanding but does not plan to specialize in neurobiology, or who wants good preparation for PHYI 722C (Electrical Signaling in Neurobiology). The cardiovascular-renal-respiratory block is also available as a 1-credit module. Additional topics include introductions to sensory nervous systme function, mouse models, endocrinology, and analysis of complex traits. Understanding of normal physiology is amplified by examples from human disease and mouse models. An excellent companion course to PATH 715. Fall. Anderson, Sealock, staff.

PHYI 705 - Communicating Scientific Results (1)
(formerly PHYI 205)
Practice in oral and written communication evaluated by peers and faculty. Includes delivery of coached presentations on topics in physiology and preparation of writing assignments typically encountered in scientific life. Fall. Stuart.

PHYI 706 - Communicating Scientific Results (1)
(formerly PHYI 206 )
Practice in oral and written communication evaluated by peers and faculty. Includes delivery of coached presentations on topics in physiology and preparation of writing assignments typically encountered in scientific life. Spring. Stuart.

PHYI 722A - Cellular and Molecular Neurobiology: Introductory Material (2)
Detailed course description
(formerly PHYI 222A)
Prerequisite, permission of course director. Introductory section covers basic neurobiology, including neuronal cell biology, action potentials, synaptic potentials, molecular biology and neuroanatomy. Course meets for four weeks with six lecture hours per week. Fall. Stuart.

PHYI 722B - Cellular and Molecular Neurobiology: Receptors (2)
Detailed course description
(formerly PHYI 222B)
Consideration of membrane receptor molecules activated by neurotransmitters in the nervous system, with emphasis on ligand binding behavior, and molecular and functional properties of different classes of receptors. Course meets for five weeks with six lecture hours per week. Fall. Stuart and faculty.

PHYI 722C - Cellular and Molecular Neurobiology: Electrical Signaling (2)
Detailed course description
(formerly PHYI 222C)
Prerequisite, permission of course director. The genesis of electrical impulses in the nervous system is considered with an emphasis on membrane potentials, voltage-gated ion channels, and structural features of neurons that influence coding. Course meets for five weeks with six lecture hours per week. Fall. Stuart.

PHYI 723A - Cellular and Molecular Neurobiology: Postsynaptic Mechanisms-Intracellular Signaling (2)
Detailed course description
(formerly PHYI 223A)
Prerequisite, permission of the course director. Explores biochemical signal transduction events following activation of neurotransmitter receptors including G-protein coupling, desensitization, signaling specificity, downstream effectors, calcium signaling, and tryrosine kinases. Course meets for five weeks with six lecture hours per week. Spring. Stuart and faculty.

PHYI 723B - Cellular and Molecular Neurobiology: Presynaptic Mechanisms (2)
Detailed course description
(formerly PHYI 223B)
Prerequisite, permission of the course director. Explores mechanisms regulating the release of neurotransmitters from nerve terminals including quantal release, vesicle and terminal membrane proteins, neurotransmitter transporters, and plasticity of synaptic transmission. Course meets for five weeks with six lecture hours per week. Spring. Stuart and faculty.

PHYI 724 - Developmental Neurobiology (3)
(formerly PHYI 122)
Prerequisite, permission of the instructor. A survey of nervous system development emphasizing detailed analysis of selected research topics such as neuronal induction, neural crest development, neuronal differentiation, synapse formation, neurotrophic factors, glial development, and the effects of experience. Fall. Crews, Polleux and faculty.

PHYI 751/752 - Seminar in Physiology (1)
(formerly PHYI 220/221)
Prerequisite, permission of the director of graduate studies. Weekly seminars emphasize current literature. Faber and staff.

PHYI 800 - Teaching Physiology (1-3)
(formerly PHYI 300)
Prerequisite, permission of the course director. Introduces the principles of teaching physiology. Provides students the opportunity to plan instruction and to teach with increasing degrees of responsibility. The teaching internship is under the direct supervision of a faculty mentor. Fall, Spring. Faber, faculty.

PHYI 824 - Pain and Somatic Sensation (2)
(formerly PHYI 224)
Prerequisites, PHYI 200 or equivalent and permission of the instructor. Consideration of peripheral and central neural mechanisms for somatic sensation with particular emphasis on pain. Spring. Perl.

PHYI 837 - Epithelial Biology (1)
(formerly PHYI 239A)
Biology of epithelia from cells to organs, focusing on the airway, gastrointestinal tract and disease. Fall. Anderson, Davis, Randell.

PHYI 838 - Excitable Membranes, Receptors, Channels and Synapses (1)
(formerly PHYI 239B)
Basic neurophysiology of excitable membranes, receptors, channels and synapses as the basis of neuronal communication. Fall. Rosenberg, Sealock.

PHYI 839 - Central Nervous System Organization, Integration and Plasticity (1)
(formerly PHYI 239C)
Primary literature will be used to provide an understanding of how the nervous system is organized, integrates information and adapts. Fall. Farel, Perl, Whitsel.

PHYI 840 - Advanced Concepts in Physiology: Renal/Cardiovascular Systems (3)
(formerly PHYI 240)
Prerequisites, PHYI 200 or equivalent and permission of the instructor. Blood pressure control in normal, diseased, and genetically modified animals.  Physiology and pathophysiology of the renal and cardiovascular systems. Fall. Arendshorst, Goy, staff.

PHYI 850 - Seminar in Neurobiology (Biochemistry 850/ Neurobiology 850/Pharmacology 850) (3)
(formerly PHYI 290)
Prerequisite, permission of the director of the Neurobiology Curriculum. An intensive consideration of selected topics and problems. The course focuses on the development of presentation and evaluation skills of the trainees. Spring. Faculty of the Neurobiology Curriculm.

PHYI 891/892 - Special Topics in Physiology (1-5)
(formerly PHYI 211/212)
Prerequisite, permission of the instructor. Individually arranged in-depth programs of study of selected topics such as membrane function, transport physiology, renal physiology. Staff.