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Anderson Lab - Images

Figure 1 claudins Figure 2 claudin10_mousecolon
  Figure 3 claudin_structure 
Figure 4  anderson fig 4 Figure 5 anderson fig 5 Figure 6  anderson fig 6
Figure 7  anderson fig 7 Figure 8  anderson fig 8    


 claudins
Figure 1. Speculative model of claudins lining the tight junction pores. Taken from
Van Itallie and Anderson. 2004. Physiology 19:331-338.

 

 

 claudin10_mousecolon
Figure 2. Immunolocalization of claudin-10 (red) and ZO-1 (green) in mouse colon. Merge (yellow) shows this member of the claudin family is restricted to the tight junctions of crypt cells. Nuclei (blue).

 

claudin_structure
Figure 3. Structure of the claudin-binding fragment of Clostridium perfringens enterotoxin (residues 194-319). Tyrosines 306, 310 and 312 are required for binding to claudin.

anderson fig 4
Figure 4. Expression of claudin-2 in MDCK cell monolayers specifically increases the permeability for solutes which are smaller than 4 Ångstroms.

 

 

 

 

 

 

 

 

 

 

 

anderson fig 5
Figure 5. Z-axis confocal image of a 2D MDCK cell monolayer stained for ZO-1 (green) and claudin-4 (red).

 

 

 

 

 

 

 

 

 

 

 

anderson fig 6
Figure 6. Confocal cross-sectional image of a 3D MDCK cell cyst stained for ZO-1 (green) and actin (red).

 

 

 

 

 

 

 

 

 

 

 

anderson fig 7
Figure 7. Confocal reconstruction image of a 3D MDCK cell cyst stained for ZO-1 (green) and actin (red).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 anderson fig 8
Figure 8. Immunostaining for claudin-10 in mouse kidney. Tight junctions are highly interdigitated in cells of the thin ascending limb of the loop of Henle. This increases the cross-sectional length of the paracellular pathway. No interdigitations are seen in junctions of the descending limb. ZO-1 (red).

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