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Cell & Molecular Physiology

111 Mason Farm Road
5200 Medical Biomolecular Research Building
CB 7545 Chapel Hill, NC 27599-7545

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Tzima - Publications

Pubmed:

Pubmed List

Recent Publications:

Sweet DT, Chen Z, Wiley DM, Bautch VL and Tzima E. The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis. Blood. Blood. Epub 2011 Nov 16.

McCormick ME, Goel R, Fulton D, Oess S, Newman D, Tzima E. Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3-Dependent NOSTRIN Expression. Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):643-9. Epub 2010 Dec 23.

Collins C, Tzima E. Hemodynamic forces in endothelial dysfunction and vascular aging. Exp Gerontol. 2011 Feb-Mar;46(2-3):185-8. Epub 2010 Oct 1.

Chen Z, Rubin J, Tzima E. Role of PECAM-1 in Arteriogenesis and Specification of Preexisting Collaterals. Circ Res. 2010 Nov 26;107(11):1355-63. Epub 2010 Oct 7.

Brown MV, Reader JS and Tzima E. (2009) Evolutionary adaptation of mammalian aminoacyl-tRNA synthetases: non-canonical functions of the protein translation machinery. Vascul Pharmacol. 2010 Jan-Feb;52(1-2):21-6. Epub 2009 Dec 3. Review.

Sweet DS and Tzima E. (2009) Rho Family Small GTPases in Shear Stress Signaling. In: "Hemodynamics and Mechanobiology of the Endothelium." World Scientific and Nature Publishing Group.

Chen Z, Tzima E. (2009) PECAM-1 is necessary for flow-induced vascular remodeling. Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1067-73. Epub 2009 Apr 23.

Sweet DT, Tzima E. (2009) Spatial signaling networks converge at the adaptor protein Shc. Cell Cycle. 8(2):231-5.

Cheng G, Zhang H, Yang X, Tzima E, Ewalt KL, Schimmel P, Faber JE. (2008) Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability. Am J Physiol Regul Integr Comp Physiol. 295(4):R1138-46.

Liu Y, Sweet D, Irani-Tehrani M, Maeda N and Tzima E. (2008) Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation. J Cell Biol. 182(1):185-96.

Goldfinger LE#, Tzima E#, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. (2008) Localized α4 integrin Phosphorylation Directs Shear Stress-Induced Endothelial Cell Alignment. Circ Res. 103(2):177-85. (#equal contribution)

Kapoor M, Zhou Q, Otero F, Myers CA, Bates A, Belani R, Liu J, Luo JK, Tzima E, Zhang DE, Yang XL, Schimmel P. Evidence for annexin II/S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS. J Biol Chem. 283(4):2070-7.

Greenberg Y, King M, Kiosses WB, Ewalt K, Yang XL, Schimmel P, Reader JS, Tzima E. (2008) The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells. FASEB J. 22(5):1597-605.

Tzima E. (2006) Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Shear Stress Response. Circ Res. 98:176-185.

Tzima E and Schimmel P. (2006) Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase. Trends Biochem Sci. 31(1):7-10.

Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H and Schwartz MA. (2005) A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature. 437(7507):426-31. (Featured at Nature Reviews Drug Discovery 4, 883-883 Research Highlight: “Go with the Flow”; Science STKE, 2005 , p. tw333 Editors' Choice “PECAM-1 as a fluid shear stress sensor”; Faculty of 1000 Biology, Factor 9.8 “Exceptional”)

Tzima E, Reader JS, Irani-Tehrani M, Ewalt KL, Schwartz MA, Schimmel P. (2005) VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. J Biol Chem. 280(4):2405-8.

Katsumi A#, Orr AW#, Tzima E#, Schwartz MA. (2004) Integrins in Mechanotransduction. J. Biol. Chem. 279:12001-4.
#These three authors contributed equally and are listed in alphabetical order

Tzima E, Reader JS, Irani-Tehrani M, Ewalt K, Schwartz MA and Schimmel P. (2003) Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells. Proc Natl Acad Sci USA, 100:14903-7.

Tzima E, Kiosses WB, del Pozo MA and Schwartz MA. (2003) Localized Cdc42 activation mediates MTOC positioning in endothelial cells in response to fluid shear stress. J. Biol. Chem. 278: 31020-3.

Tzima E, del Pozo, MA, Kiosses WB, Mohamed S, Li S, Chien S and Schwartz MA. (2002) Activation of Rac by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J. 2:6791-800.

Tzima E, del Pozo MA, Shattil SJ, Chien S, Schwartz MA.(2001) Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J. 20:4639-47.