faculty research interests  
   
 
Headlines
     
    John F. Rawls is a 2008 Pew Scholar Award recipient.
    Philpot to share Simons Foundation grant for study of Ube3a and Angelman syndrome/autism
    Tzima lab postdoc, Zhongming Chen, PhD, recieves AHA Fellowship
    C&M Physiology meets with The Hamner Institutes for Health Sciences
    A gene discovered in the OTEY lab is mutated in familial pancreatic cancer - See New York Times article >>
    KAY LUND receives 2008 University Award for the Advancement of Women
    CARON LAB news: Adrenomedullin plays an important role in the formation of the lymphatic system
    ANN STUART receives the 2007 Educator of the Year Award from the Faculty for Undergraduate Neuroscience
    ELLIE TZIMA receives the 2007 Ellison Medical Foundation New Scholar Award in Aging on "The Role of Hemodynamic Forces in Endothelial Dysfunction and Vascular Aging."
    BHAT LAB uncovers new roles of neurexin in the structure and function of nerve cells - in the journal Neuron 55:741-755
    PHILPOT et al. find causal link between NMDA receptor subunit composition and metaplasticity - cover story in Neuron
 
 
 

NEWS

 
         
 

April 18, 2008

hamner meeting

 

Physiology department faculty met with researchers and administrators at The Hamner Institutes for Health Sciences in RTP to learn about respective programs and begin discussions about possible new collaborations.

Our faculty represented the first group to meet following the establishment of a Memorandum of Understanding (MOU) between The Hamner and UNC schools of medicine, public health, and pharmacy as well as the Kenan-Flagler Business School.

The Hamner's focus on reproductive and developmental biology and respiratory biology aligns with the work of several faculty members here in Physiology. The Hamner has "adopted systems biology as a guiding research paradigm," which relates back to the fundamentals of physiology, as is described on their website:

In a sense, contemporary systems biology is a renaissance of physiology, a traditional integrative discipline. Biological research has enjoyed decades of success in dissecting the structures and functions of individual molecular and cellular components comprising an organism. However, the inherent complexity of biological systems, due not only to the large number of their constituents, but also to the intricate web of interactions between these constituents, have proven difficult to understand with reductionist approaches. Research has to be conducted at a more global, systems-level in order to gain understanding of the overall behavior of the biological networks that maintain normal physiology and the perturbations in these networks that lead to toxicity and disease.

 Read The Hamner's press release here [pdf].

 
  Physiology's Dr. Jim Faber (at right) speaks with Dr. William Greenlee (center), President and CEO of The Hamner Institutes, and Dr. Charles Hamner (left), Chairman of the Hamner's Board of Trustees.    
 

HONORS & AWARDS

 
 
June 2008
  rawls

John F. Rawls has been chosen as a 2008 Pew Scholar. The Pew Scholars Program in the Biomedical Sciences is designed to support young investigators of outstanding promise in the basic and clinical sciences relevant to the advancement of human health. Scholars are awarded $60,000 per year for a four-year period.

more >>

 
         
 
May 2008
 
ben philpot
Ben Philpot and collaborator Mike Ehlers received a prestigious grant from the Simons Foundation for the work they are doing on Ube3a and Angelman syndrome/autism. 
 
       
 
May 2008
 
zhongming chen
Zhongming Chen, PhD, (Tzima lab) received an American Heart Association Postdoctoral Fellowship for 2 years to study the role of PECAM-1 in shear stress signaling.  
         
 
April 2008
 

Sushmita Jha

Graduate student Sushmita Jha (Ting lab) received the Hulka Innovators Award for her presentation on "Cryopyrin(CIAS1): a novel regulator of IL-1beta production and its role during neuroinflammation and demyelination" at the 2008 Women's Health Research Day, sponsored by the Center for Women's Health Research at UNC.

This award is given "in honor of Dr. Jaroslav F. Hulka in recognition of innovation in methods, population, study design, or study content area, with an emphasis on having made a novel contribution to advancing science."

 
         
 
April 2008
 

Nicole Ramocki, PhD

Recent Physiology graduate Nicole Ramocki was awarded a 2008 Impact Award by the UNC-Chapel Hill Graduate School's Graduate Education Advancement Board. The Impact Awards "recognize graduate students whose research provides special benefits to the citizens of North Carolina." Read more about Impact Awards >>

 
         
 
March 2008
  Kay Lund, PhD

Dr. Lund is one of three recipients of this year's University Awards for the Advancement of Women. This prestigious award was created in 2006 as an opportunity for the UNC academic community to recognize and reward individuals for their contributions on behalf of women on this campus. Read UNC School of Medicine press release.


 
       
 
November 2007
 

Ann Stuart, PhD, received the Educator of the Year Award given by the Faculty for Undergraduate Neuroscience (FUN). The current president of FUN, Bruce R. Johnson, PhD, of Cornell University, presented the award and acknowledged her work on the Neurons in Action software.

 
         
 
November 2007
 

Eleni Tzima, PhD

Assistant professor of cell and molecular physiology in the School of Medicine, Tzima has been named a 2007 Ellison Medical Foundation New Scholar. The award provides $200,000 over four years in support of research on the role of blood flow in cardiovascular disease, primarily among the elderly.

The Ellison Foundation New Scholars award supports exceptional young faculty who are nominated by U.S. medical institutions and universities for their outstanding promise in aging research.

 
 
     
 
September 25, 2007
 

Rachael Rigby, Ph.D. received a 2007 Postdoctoral Scholars Award for Research Excellence for her research in the Lund lab on inflammatory bowel disease and Crohn's disease, particularly how the disease affects the epithelial lining of the intestine and its risk of inappropriate cell division leading to cancer.

The awards are given in recognition of the research promise demonstrated by individual postdoctoral scholars.

Gazette article

 
 
     
 
June 2007
  Nicole Ramocki (Lund lab) - Mara E. Lieberman Travel Grant recipient, Endocrine Society, Toronto, ON, Canada.  
     
 
May 2007
 

Dr. Carlton Cuyler Hunt, professor emeritus of physiology, elected to the American Academy of Arts and Sciences.

Dr. Hunt led in the discovery and description of a system of neurons controlling the sensitivity and activity of the muscle stretch receptor (the vertebrate muscle spindle), which was a first indication that the central nervous system can control the activity that it receives from peripheral sense organs. Hunt's subsequent work on vibration reception by the Pacinian corpuscle and on the correlation between afferent fiber conduction velocity and afferent function are important landmarks in the development of insight into somatic sensory mechanisms.

UNC News release

 
     
 
May 2007
 

Dr. James M. Anderson receives the 2007 Takeda Distinguished Research Award

The Takeda Distinguished Research Award is given by the American Physiological Society's Gastrointestinal & Liver Physiology Section and recognizes an outstanding investigator who is internationally recognized for his/her contribution to research in areas represented by the GIL Section.

Anderson homepage

 
 
     
 
April 2007
 

Center for Women’s Health Research Award for Excellence, 8TH Annual  Women’s Health Research Day, Chapel Hill, NC, April 2007

Congratulations to Dr. Silvia Goicochea, Research Instructor in Cellular & Molecular Physiology,  for receiving the Center for Women's Health Research Award for Excellence at the 8th Annual Women's Health Research Day held on April 3-4, 2007 at the Friday Center.  The cash award is presented for multidisciplinary research that best demonstrates the strength of collaborative investigation. 

She received the award for her poster presentation, "Palladin expression in metastatic breast cancer cells: a role in invasive motility."

Over 60 presentations were selected for the program this year.  Women's Health Research Day is sponsored by the Center for Women's Health Research at UNC.

 
 
 
    PUBLICATIONS  
       
 
               
JCI cover
     
Adrenomedullin signaling is necessary for murine lymphatic vascular development

Kimberly L. Fritz-Six, William P. Dunworth, Manyu Li and Kathleen M. Caron


[Full Text] [PDF] [Commentary]

The lymphatic vascular system mediates fluid homeostasis, immune defense, and tumor metastasis. Only a handful of genes are known to affect the development of the lymphatic vasculature, and even fewer represent therapeutic targets for lymphatic diseases. Adrenomedullin (AM) is a multifunctional peptide vasodilator that transduces its effects through the calcitonin receptor–like receptor (calcrl) when the receptor is associated with a receptor activity–modifying protein (RAMP2). Here we report on the involvement of these genes in lymphangiogenesis... [Full Abstract]
Caron homepage >>
 
           
 
       
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bhat cover
     
Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth, and Synaptic Transmission

Jingjun Li, James Ashley, Vivian Budnik, and Manzoor A. Bhat

[Full Text] [PDF] [Supplemental Data]
Neurexins have been proposed to function as major mediators of the coordinated pre- and postsynaptic apposition. However, key evidence for this role in vivo has been lacking, particularly due to gene redundancy. Here, we have obtained null mutations in the single Drosophila neurexin gene ( dnrx ). dnrx loss of function prevents the normal proliferation of synaptic boutons at glutamatergic neuromuscular junctions, while dnrx gain of function in neurons has the opposite effect. DNRX mostly localizes to the active zone of presynaptic terminals. Conspicuously, dnrx null mutants display striking defects in synaptic ultrastructure, with the presence of detachments between pre- and postsynaptic membranes, abnormally long active zones, and increased number of T bars. These abnormalities result in corresponding alterations in synaptic transmission with reduced quantal content. Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments.
Bhat homepage >>
 
       
               
neuron cover
     
Obligatory Role of NR2A for Metaplasticity in Visual Cortex

Benjamin D. Philpot, Kathleen K.A. Cho, and Mark F. Bear

[Summary] [Full Text] [PDF] [Supplemental Data]
Modification of synapses by neural activity is the substrate for experience-dependent brain development, learning, and recovery of function after brain damage. Previous work in visual cortex has shown that the threshold level of activity required to modify synapses (the modification threshold) varies depending on the recent history of visual experience, a phenomenon called metaplasticity. Adjustments of the modification threshold correlate with changes in the subunit composition and function of NMDA receptors. Here Philpot et al. provide a causal link between NMDA receptor subunit composition and metaplasticity. This finding represents an important step forward in understanding how plasticity thresholds are regulated in the brain.
Philpot homepage >>
 
           
 
       
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Palladin Mutation and Familial Pancreatic Cancer
   
Palladin, a gene discovered in the Otey lab, is found to cause an inherited form
of pancreatic cancer
 
         
Journal article >>  
   
in PLoS Medicine, Dec 12, 2006
 
         
  Press reports >> New York Times 3/18/08 (pdf)
otey
   
    Scientific American  (pdf)  
    People's Daily (China) (pdf)
 
    MedIndia (pdf)    
    PhysOrg (pdf)      
    eMaxHealth (pdf)