Interdisciplinary Program in Biomedical Sciences



	Participating Faculty Alphabetical Listing Areas of Study Listing
	Alphabetical Listing A B C D E F G H I J K L M N O P Q R S T U V W X Y Z = Home Page

A			Alphabetical Listing Top

Shawn Ahmed - Curriculum in Genetics & Molecular Biology, Biology My laboratory is interested in telomere replication, in DNA damage, and in germline immortality. We are studying these problems using the nematode Caenorabditis elegans, which is a higher eukaryote with very good genetics.
James Anderson Cell & Molecular Physiology Tight junctions are intercellular contacts that form a barrier required for ion transport and organization of cell polarity. Our lab investigates assembly and regulation of TJ proteins and the molecular basis for ion selectivity in epithelia.
Eva Anton Cell & Molecular Physiology, Curriculum in Neurobiology Laminar organization of neurons in cerebral cortex is critical for cognitive function. Two distinct cellular events guarantee emergence of laminar organization—coordinated sequence of neuronal migration and generation of radial glial cell scaffold.
William Arendshorst Cell & Molecular Physiology We study arterioles that vascular resistance in healthy kidneys and kidneys of genetic hypertensive animals or those with mutated selected genes. Measurements include renal vascular reactivity in vivo and receptor/calcium signaling in vitro.

B			Alphabetical Listing Top

Steven Bachenheimer Microbiology & Immunology, Curriculum in Genetics & Molecular Biology, Curriculum in Neurobiology Alterations to cell-cycle and signal transduction pathways following herpes simplex virus infection.
Albert S. Baldwin Curriculum in Genetics and Molecular Biology Our laboratory studies an amazing regulatory factor known as NF-kappaB. This transcription factor controls key developmental and immunological functions and its dysregulation lies at the heart of virtually all major human diseases.
Vytas A. Bankaitis Cell & Developmental Biology We study the interface between signal transduction and cell function. Approaches employed include: molecular genetics, protein and lipid biochemistry, confocal and electron microscopy, and mouse gene knockout technology.
Ralph Baric Microbiology & Immunology Coronaviruses, including SARS and Noroviruses are used as models to study the genetics of RNA virus transcription, replication, persistence, cross species transmission and vaccine development.
Victoria Bautch Biology, Curriculum in Genetics & Molecular Biology Blood vessel formation in cancer and development; use mouse culture (stem cell derived vessels) and in vivo models (embryos and tumors); genetic, cell and molecular biological tools; how do vessels assemble and pattern?, dynamic image analysis.
James E. Bear Cell and Developmental Biology My lab works on actin-based motility. We study the dynamic reorganization of the actin cytoskeleton in response to extracellular cues.
Con Beckers Cell & Developmental Biology We study the cell biology of the protozoan parasites that cause Toxoplasmosis and Malaria, especially the mechanism and control of parasite motility and host cell interaction.
Manzoor Bhat Cell & Molecular Physiology, Curriculum in Neurobiology Axon-glial Interaction, Myelination, blood-nerve barrier formation, synaptogenesis
Kerry Bloom Biology, Curriculum in Genetics & Molecular Biology Our objective is to understand the dynamic and structural properties of chromosomes during mitosis. We use live cell imaging techniques to address how kinetochores are assembled, capture microtubules and promote faithful segregation of chromosomes.
Bob Bourret Curriculum in Genetics & Molecular Biology, Microbiology & Immunology Our goal is to define the molecular mechanisms of signal transduction in bacteria. We currently focus on the mechanisms, regulation, and consequences of the protein phosphorylation and dephosphorylation reactions that control chemotaxis in E. coli.
Miriam Braunstein Microbiology & Immunology, Curriculum in Genetics & Molecular Biology Our research focuses on understanding the virulence mechanisms of Mycobacterium tuberculosis, the bacterium responsible for the disease tuberculosis.
Jay Brenman Cell & Developmental Biology, Curriculum in Genetics & Molecular Biology, Curriculum in Neurobiology We exploit Drosophila genetics to identify genes required to form neuronal dendrites. We exploit transgenic fruit flies expressing GFP in neurons to conduct forward genetic screens including anatomical and enhancer/suppressor screens. Confocal microscopy, molecular genetics, and protein biochemistry are utilized to characterize candidate genes and mutants
Patrick Brennwald Cell & Developmental Biology We are interested in the mechanism by which eukaryotic cells are polarized and the role of vesicle transport plays in the determination and regulation of cell polarity and tumorigenesis.
Christina Burch Biology, Microbiology & Immunology, Curriculum in Genetics and Molecular Biology Virus Evolution. Two of our main focusses are 1) how genome complexity constrains adaptation, and 2) how ecology and genetics affect virus host range.
Keith Burridge Cell and Developmental Biology Cell adhesion, both to other cells and to ECM, signaling, the cytoskeleton and cell migration. The Rho family of GTPases, their regulation by guanine nucleotide exchange factors and GAPs. Inflammation and leukocyte transendothelial migration.
C			Alphabetical Listing Top

Sharon Campbell Biochemistry & Biophysics, IBMS Current research projects in the Campbell laboratory include: structural, biophysical and biochemical studies of wild type and variant Ras and Rho family GTPase proteins, as well as the identification, characterization and structural elucidation of factors that act on Ras and Rho family GTPase proteins.
Janne Cannon Microbiology & Immunology, Curriculum in Genetics & Molecular Biology We study how pathogenic bacteria evade host defenses, using Neisseria gonorrhoeae and the potential biowarfare agent Francisella tularensis. Antigenic variation mechanisms, role of DNA repair in pathogenesis, surface components.
Regina M. Carelli Curriculum in Neurobiology Our research focuses on understanding the biological basis of motivated behaviors. We use electrophysiological and electrochemical procedures to study the role of the brain “reward” circuit in mediating both “natural” and drug (e.g. cocaine) reward.
Kathleen Caron Cell & Molecular Physiology Gene targeting and state-of-the-art phenotyping methods are used to elucidate the reproductive and cardiovascular roles of the adrenomedullin system and to characterize the novel GPCR-signaling mechanism of Adm’s receptor and RAMP’s.
Charles Carter, Jr. Biochemistry & Biophysics Tryptophanyl-tRNA Synthetase stores free energy as strain when it binds ATP. We study this with crystallography, molecular dynamics and thermodynamics. We are also pursuing the sense/antisense ancestry of the two aaRS classes.
Stephen G. Chaney Biochemistry & Biophysics, Curriculum in Toxicology, Curriculum in Genetics & Molecular Biology Platinum anticancer agents, DNA repair, mutagenesis, translation DNA polymerases, molecular modeling.
Richard Cheney Cell & Molecular Physiology, Curriculum in Neurobiology Our research centers on the cell biology and biochemistry of motor proteins and the cytoskeleton and their roles in processes such as cell crawling, phagocytosis, organelle transport.
Frank C. Church Pathology & Laboratory Medicine, Pharmacology Our research is concerned with proteases and their inhibitors in various disease processes (thrombosis and cancer); our “science tools” are structure-activity, cell biology and signaling, pathobiology, immunohistochemistry, and in vivo models.
David R Clemmons Biochemistry & Biophysics Cross-talk between insulin like growth factor -1 and cell adhesion receptors in the regulation of cardiovascular diseases and complications associated with diabetes
William Coleman Pathology, Curriculum in Toxicology Our research involves (i) identification/characterization of human liver tumor suppressor genes, (ii) methylation-dependent epigenetic regulation of BRCA1 in breast cancer, (iii) molecular discrimination of multiple primary lung cancers.
Edward J. Collins Microbiology and Immunology, Biochemistry and Biophysics Understanding the physical basis of T cell activation using x-ray crystallography, other biophysical techniques, and immunological assays. Pathogenesis of Francisella tularensis.
Frank Conlon Biology, Curriculum in Genetics & Molecular Biology We are studying the molecular mechanisms that are involved in the induction and patterning of the early heart tube.
Jeanette Cook (Jean) Biochemistry & Biophysics, Genetice & Molecular Biology, Pharmacology We study DNA replication licensing, the process that renders replication origins competent to be copied. We investigate how the replication process is linked to signaling pathways that gather and transmit information about the cellular environment.
Gregory P. Copenhaver Biology, Curriculum in Genetics & Molecular Biology One of the primary research areas my lab is understanding how meiotic recombination is regulated at the genomic level in higher eukaryotes. A second research area in the lab is the role of centromere DNA in chromosome biology.
Marila Cordeiro-Stone Pathology & Laboratory Medicine, Curriculum in Toxicology DNA replication, DNA repair, translesion DNA synthesis, mutagenesis, and cell cycle checkpoints in human cells. Localization of DNA replication origins and their organization in human chromosomes.
Joe Costello Cell & Developmental Biology The main research project is to determine the role of intercellular junctions in normal development, cell aging and cataract formation in human and animal lenses.
Adrienne Cox Curriculum in Genetics & Molecular Biology, Pharmacology Our lab is interested in molecular mechanisms of oncogenesis, specifically as regulated by Ras and Rho family small GTPases. We are particularly interested in understanding how membrane targeting sequences of these proteins mediate both their subcellular localization and their interactions with regulators and effectors. Both Ras and Rho proteins are targeted to membranes by characteristic combinations of basic residues and lipids that may include the fatty acid palmitate as well as farnesyl and geranylgeranyl isoprenoids. The latter are targets for anticancer drugs; we are also investigating their unexpectedly complex mechanism of action. Finally, we are also studying how these small GTPases mediate cellular responses to ionizing radiation - how do cells choose whether to arrest, die or proliferate?
Fulton Crews Curriculum in Neurobiology, Pharmacology Research in the laboratory focuses on mechanisms of neurodegeneration and regeneration, particularly stem cells in brain.
Stephen Crews Biochemistry & Biophysics, Biology, Curriculum in Genetics & Molecular Biology, Curriculum in Neurobiology Research in the lab is focused on three major areas: (1) Neurogenomic analysis of Drosophila CNS development, (2) Brain development and behavior, and (3) Control of tracheal cell migration and fusion events.
Douglas M. Cyr Cell & Developmental Biology The Cyr laboratory studies cellular mechanisms for cystic fibrosis and prion disease. We seek to determine how protein misfolding leads to the lung pathology associated with Cystic Fibrosis and the neurodegeneration associated with prion disease.

D			Alphabetical Listing Top

Blossom Damania Dept. of Microbiology and Immunology Our lab studies viral genes involved in signal transduction and transcription of Kaposi's sarcoma-associated herpesvirus (KSHV) and its simian relative, rhesus monkey rhadinovirus (RRV).
Jeff Dangl Biology, Curriculum in Genetics & Molecular Biology We use a model plant species, Arabidopsis thaliana, and real world plant pathogens to understand the molecular nature of host-microbe interactions. All of our organisms are sequenced, making the powers of genomics accessible.
C. William Davis Cell & Molecular Physiology Cellular and molecular basis of the mucociliary clearance system in the airways of the lung. Our focus is on the regulation of mucin secretion and ciliary activity at the cell and molecular levels.
Ian Davis Curriculum in Genetics & Molecular Biology With a particular interest in pediatric solid tumors, our lab aims to develop a mechanistic understanding of the role of aberrant or dysregulated transcription factors in oncogenesis.
Channing Der Pharmacology, Curriculum in Genetics & Molecular Biology, Curriculum in Toxicology Our research centers on understanding the molecular basis of human carcinogenesis. This involves the dissection of the role of Ras and Rho GTPases in signaling and oncogenesis.
Mohanish Deshmukh Cell & Developmental Biology, Curriculum in Neurobiology, Curriculum in Toxicology Our research interests are in understanding the signaling events and molecular pathways that regulate apoptosis in mammalian cells. We are particularly interested in identifying and studying unique aspects of this pathway in neurons.
Aravinda de Silva Microbiology and Immunology We study Borrelia burgdorferi (the agent of Lyme disease) as a model for understanding arthropod vector-borne disease transmission. We also study the epidemiology and pathogenesis of dengue viruses associated with hemorrhagic disease.
Joseph M. DeSimone Pharmacology The direct fabrication and harvesting of monodisperse, shape-specific nano-biomaterials are presently being designed to reach new understandings and therapies in cancer prevention, diagnosis and treatment.
Dirk Dittmer Microbiology & Immunology Our lab tries to understand viral pathogenesis. To do so, we work with two very different viruses: West Nile Virus (WNV) and Kaposi¹s sarcoma-associated herpesvirus (KSHV/HHV-8).
Henrik Dohlman Biochemistry & Biophysics, Pharmacology We use genetic and biochemical approaches to study molecular mechanisms of hormone and drug desensitization. Our current focus is on regulation by protein ubiquitination and by RGS proteins (regulators of G protein signaling).
Nikolay Dokholyan Biochemistry & Biophysics We study the mechanisms of protein folding and aggregation, and relations between aberrant protein dynamics and human diseases. Specifically, using molecular dynamics simulations and in experiments, we study the how the folding dynamics of superoxide dismutate is affected by mutations leading to Familial Amyotrophic Lateral Sclerosis (FALS, Lou Gehrig’s disease).
Bob Duronio Biology, Curriculum in Genetics & Molecular Biology Research into the mechanisms of cell cycle control during animal development, including how transcription (RB/E2F), pre-mRNA processing (histone expression), and protein ubiquitination/proteolysis (SCF ubiquitin ligase) regulate the G1-S transition.

E			Alphabetical Listing Top

Chris Elkins Microbiology & Immunology My lab is studying the biology of H. ducreyi the etiologic agent of chancroid. Chancroid is one of the genital ulcer diseases and is an important risk factor for the transmission of HIV in Africa. Chancroid elimination would reduce HIV transmission.
Ann Erickson Biochemistry & Biophysics We are characterizing the structural signals that are responsible for moving enzymes normally stored intracellularly in lysosomes into the extracellular environment, where they may participate in tumor cell metastasis.
Eric Everett Curriculum in Genetics & Molecular Biology Investigation of genes/proteins that play key roles during embryonic and postnatal development of craniofacial/oral/dental structures; and their contribution to normal variation and to congenital and acquired disorders.

F			Alphabetical Listing Top

James Faber Cell & Molecular Physiology This lab studies vascular biology and physiology, with specific focus on the signaling mechanisms directing 1) normal adaptive and pathological growth of the vascular wall, 2) arteriogenesis (formation of collateral vessels) in models of tissue ischemia. Please see my departmental web page for more details.
Rosann Farber Pathology & Laboratory Medicine, Curriculum in Genetics & Molecular Biology Genetic instability in cultured human cells, microsatellite mutations, DNA mismatch repair, hereditary nonpolyposis colorectal cancer (HNPCC), human genetics, somatic-cell genetics.
Paul Farel Cell & Molecular Physiology, Curriculum in Neurobiology A third of sensory neurons express their adult phenotype only as the juvenile grows. This previously unrecognized postnatal differentiation offers the possibility of enlisting the underlying mechanisms to compensate for injury or disease.
Thomas Fischer Pathology & Laboratory Medicine The research program of Dr. Fischer focuses on three closely related areas. Mechanisms for atherogensis, processes of platelet-mediated hemostasis and mechanisms for surface hemostasis.
Pat Flood Microbiology & Immunology My research studies the role of T and B cells in immunologic responses: the activity of cytokines produced in chronic inflammatory and anti-tumor immune responses and the role of thymus-independent antigens in B cell subset development.
Jeffrey Frelinger Microbiology & Immunology, Curriculum in Genetics & Molecular Biology Our work is focused on understanding how major histocompatibility complex (MHC) molecules function in the immune response to pathogens. This simple question involves the most fundamental aspect of immunology: self/non-self discrimination.
Howard Fried Biochemistry & Biophysics Mechanisms of eukaryotic RNA: protein complex (RNPs) assembly. How do the RNA and protein components get together? Do RNP components assemble in defined order? Does assembly occur by cooperative interactions that may regulate RNP production.

G			Alphabetical Listing Top

Martina Gentzsch Cell & Developmental Biology My work at the Cystic Fibrosis Research Center focuses on intracellular trafficking of CFTR, the apical chloride channel mutated in cystic fibrosis.
Morgan Giddings Microbiology & Immunology, Biomedical Engineering We are developing both proteomics and informatics methods in application to two major research problems: determination of the number and location of genes on the human genome, and understanding the development of antibiotic resistance in microbes.
Bob Goldstein Biology, Curriculum in Genetics & Molecular Biology We are using C. elegans embryos to address basic questions in cell and developmental biology—how cells move to specific positions, how complexes of proteins and RNAs are positioned in cells and how the mitotic spindle is positioned in cells.
John Gilmore, MD Curriculum in Neurobiology Research focuses on the mechanism through which prenatal exposure to infection alters early cortical development, focusing on cytokine and neurotrophic factors. I am also study human brain development with ultrasound and MRI.
Michael Goy Cell & Molecular Physiology, Curriculum in Neurobiology How do target organs communicate with neural circuits? We investigate feedback regulation of a simple neural circuit that uses a novel form of muscle-to-nerve feedback to control the contractions of heart musculature.
Lee M. Graves Curriculum in Toxicology, Pharmacology Our lab is studying the role of mitogen and stress-activated protein kinases to regulate key aspects of cell metabolism. We are also studying signalling by tyrosine kinases in response to toxicological agents or cell stress.
Jack Griffith Microbiology & Immunology, Biochemistry & Biophysics, Curriculum in Genetics We are interested in basic DNA-protein interactions as related to: DNA replication, DNA repair and telomere function. We utilize a combination of state of the art molecular and biochemical methods together with high resolution electron microscopes.
Margaret Gulley, MD Pathology & Laboratory Medicine Dr. Gulley's research is on Epstein-Barr virus (EBV)-related malignancies. Molecular and immunohistochemical techniques are used to characterize infected tissues. We validate new assays to help diagnose and monitor affected patients.

H			Alphabetical Listing Top

Klaus Hahn Pharmacology Development of new tools to study protein activation in living cells; spatio-temporal control of signaling networks regulating motility and apoptosis; robotic microscopy for genome-wide screens of proteins regulating signaling dynamics.
Scott Hammond Cell & Developmental Biology My lab studies a gene silencing phenomenon called RNA interference, or RNAi. We are interested in the role of RNAi in regulating endogenous genes, particularly those involved in cancer progression pathways.
Kendall Harden Pharmacology, Curriculum in Neurobiology We focus on mechanistic/structural aspects of regulatory proteins (heterotrimeric and Ras family GTPases, RGS proteins, and PLC isozymes) involved in inositol lipid signaling, and on G protein-coupled receptors for extracellular nucleotides.
Mark Heise Microbiology & Immunology We study alphavirus infection to model virus-induced disease. Projects include 1) mapping viral determinants involved in encephalitis, and 2) using a mouse model of virus-induced arthritis to identify viral and host factors associated with disease.
Clyde Hodge Curriculum in Neurobiology, Pharmacology The primary goal of our research is to elucidate the neurobiological systems that mediate the behavioral effects of alcohol and drugs of abuse.
Jonathon Homeister Pathology & Laboratory Medicine Molecular mechanisms of leukocyte trafficking and homing in inflammatory and immune reactions; glycobiology of the Selectin adhesion molecules and their ligands, and their roles in the pathophysiology of atherosclerosis and thrombotic diseases.

J			Alphabetical Listing Top

Ken Jacobson Cell & Developmental Biology Lipid rafts in biomembranes, Cell migration
L. Fredrik Jarskog, M.D. Curriculum in Neurobiology Laboratory focused on the role of apoptosis and other cellular viability proteins in the neuropathology of schizophrenia and normal cortical neurodevelopment.
Suk-Won Jin Cell & Molecular Physiology We are studying how hemangioblasts, a bipotential precursor of endothelial and hematopoietic lineages, are specified and differentiated during development using zebrafish as a model system.
Gary L. Johnson Pharmacology Spatio-temporal regulation of signal relay systems in cells using live cell fluorescence imaging and targeted gene disruption of signaling proteins to define their role in development, physiology and pathophysiology.
Alan Jones Biology, Curriculum in Genetics & Molecular Biology Signal transduction coupled by heterotrimeric G proteins. We use Arabidopsis, genetics, biochemistry, & in vivo imaging of protein-protein interactions. The type of signals we study include light, hormones, & sugars.

K			Alphabetical Listing Top

Tal Kafri Microbiology & Immunology Our lab is focused on the development of HIV-1 vectors for gene therapy of genetic disease. In addition, we are using the vector system to study HIV-1 biology. We are also interested in utilizing the HIV-1 vector system for functional genomic.
David Kaufman Biochemistry & Biophysics, Pathology & Laboratory Medicine, Curriculum in Toxicology Topic 1: We are mapping an early replicating region in band 1p36.1. Topic 2: We reconstruct human endometrial tissue from epithelial and stromal cells interacting in culture to form differentiated and functional glands.
William Kaufmann Pathology & Laboratory Medicine, Curriculum in Toxicology Research in the Kaufmann laboratory is concerned with determining the mechanisms whereby cell cycle checkpoints suppress human carcinogenesis.
Tom Kawula Microbiology and Immunology My lab studies the pathogenic mechanisms of two bacterial pathogens, Haemophilus ducreyi and Francisella tularensis. H. ducreryi, the agent of the sexually transmitted infection chancroid, somehow inhibits the development of an effective immune response in infected individuals. Thus, people who have been treated successfully remain susceptible to reinfection. We are studying the mechanisms by which H. ducreyi inhibits the development of a vigorous host immune response.
Hengming Ke Biochemistry & Biophysics Our research focuses on the structure and function of medically important proteins from the crystallographic approach. The current topics include cycolphilin, calcineurin, heat shock protein 90 (hsp90), and cyclic nucleotide phosphodiesterase.
Joe Kieber Biology, Curriculum in Genetics & Molecular Biology Hormones influence virtually every aspect of plant growth and development. My lab is examining the molecular mechanisms controlling the biosynthesis and perception of the phytohormones cytokinin and ethylene.
Suzanne Kirby Pathology Our focus is on using genetic methods to improve transplantation using ES and hematopoietic stem cells in transplant models. A second focus of the lab uses mutant mice to examine potential drug targets for ameliorating radiation-induced lung damage.
Stephen Knisley Biomedical Engineering Dr. Knisley’s laboratory develops novel optical and electrical biomeasurement techniques and associated instrumentation and computer software for studies of cardiac ischemia, arrhythmias and mechanisms of electrical stimulation and defibrillation.
Joe Kornegay Pathology & Laboratory Medicine I study a canine model of Duchenne muscular dystrophy. Both conditions occur due to mutations in the dystrophin gene. Our research has defined clinical and pathologic features to better understand disease pathogenesis and to assess treatment.
Brian Kuhlman Biochemistry & Biophysics We use a combination of experimental and computational methods to redesign protein-protein interactions. The potential applications for this technology include enhancing protein therapeutic and creating new tools to study signaling pathways.

L			Alphabetical Listing Top

Anthony LaMantia Curriculum in Genetics & Molecular Biology, Curriculum in Neurobiology, Cell & Molecular Physiology Lab research signals and effectors necessary to establish regional and cellular differences in the regions of the forebrain. Human diseases are a starting point for identifying novel genes that may participate in normal forebrain development.
Jean Lauder Cell & Developmental Biology, Curriculum in Neurobiology Neurotransmitters as developmental signals in early embryogenesis and brain development: Cellular and molecular mechanisms. Role of gene-environment interactions in the etiology of developmental disabilities.
Andrew Lee Biochemistry & Biophysics We study protein structure and dynamics as they relate to protein function and energetics. We are currently using NMR spectroscopy, computation, and a variety of other biophysical techniques to gain a deeper understanding of proteins at atomic level resolution.
John J. Lemasters Cell & Developmental Biology, Curriculum in Toxicology Mechanisms of apoptosis and necrosis to liver, heart and tumor cells; organ preservation for transplantation; mitochondrial permeability transition; confocal and multiphoton microscopy; mitochondrial calcium homeostasis; mitochondrial autophagy.
Barry Lentz Biochemistry & Biophysics The regulatory role of platelet membrane phosphatidylserine in blood coagulation; mechanism of protein-mediated membrane fusion in secretory processes and virus infection.
Jason Lieb Biology, Curriculum in Genetics & Molecular Biology We use DNA microarrays to study how and where proteins interact with the genome, and how these interactions affect the biology of living cells using yeast and C. elegans as models. Our focus is chromatin and specificity in protein-DNA interactions.
Sarah Liljegren Biology We are investigating the role of vesicle trafficking during plant cell separation and how pattern formation develops in Arabidopsis flowers.
Susan T. Lord Pathology & Laboratory Medicine, Curriculum in Genetics & Molecular Biology We study the role of the clotting protein fibrinogen. We examine variant fibrinogens, correlating structure and function using crystallographic and biochemical analyses. We study mouse models to test the link between fibrinogen and disease.
Pauline K Lund Cell & Molecular Physiology, Curriculum in Neurobiology Molecular, cellular and in vivo approaches in intestine and brain to define mechanisms by which hormones and growth factors regulate normal and aberrant tissue specific growth. Uses model cell lines, mutant mice and mouse models of disease.

M			Alphabetical Listing Top

Jeffrey Macdonald Biomedical Engineering, Curriculum in Toxicology Dr. Macdonald is the Founder and Director of the new Metabolomic Facility. Dr. Macdonald's research goal is to combine metabolomics and tissue engineering and apply these tools to quantitative biosystem analysis.
Christopher Mack Pathology & Laboratory Medicine My research goals are to identify the mechanisms by which environmental factors regulate smooth muscle cell phenotype and to define the transcriptional pathways that regulate SMC-specific gene expression.
Nobuyo Maeda Curriculum in Genetics & Molecular Biology, Pathology I have two main research projects under study at the present time. My first project concerns the molecular pathology of atherogenesis. My second project is aimed at a better understanding of how variations of genes are generated, particularly in multi-gene families.
Terry Magnuson Curriculum in Genetics & Molecular Biology The Magnuson Lab works in three areas: (i) Novel Approaches to Allelic Series of Genomic Modifications in Mammals, (ii)Mammalian Polycomb-group Complexes and development, (iii) Mammalian Swi/Snf Chromatin Remodeling Complexes
Richard Mailman Pharmacology, Neurobiology, Toxicology Structure and function of dopamine receptors; atomic and molecular mechanisms of receptor activation; molecular drug design; dopamine agonists in disease (Parkinson's disease, schizophrenia, substance abuse, etc.)
Mark Majesky Curriculum in Genetics & Molecular Biology We study development of coronary blood vessels using developmental genetic approaches in chick and mouse models. Current projects examine the role of sonic hedgehog, rhoGTPase, and T-box factors in coronary development.
Paul B. Manis Curriculum in Neurobiology, Cell & Molecular Physiology We study mechanisms of sensory information processing in the nervous system. Our experimental emphasis is on ion channels and synaptic transmission and plasticity, in the auditory brainstem and cortex. We also perform computational modeling studies.
Patricia F. Maness Biochemistry, Curriculum in Neurobiology, Curriculum in Toxicology My research focuses on molecular mechanisms of mammalian nervous system development. We investigate mechanisms by which developing neurons migrate to the neocortex and form connections.
William Marzluff Biochemistry & Biophysics, Curriculum in Genetics & Molecular Biology, Biology We are interested in the mechanisms by which histone protein synthesis is coupled to DNA replication, both in mammalian cell cycle and during early embryogenesis in Drosophila, Xenopus and sea urchins.
A. Gregory Matera Biology, Cell & Developmental Biology, Curriculum in Genetics & Molecular Biology Research in our lab is focused on molecular mechanisms of small nuclear ribonucleoprotein (snRNP) biogenesis. Particular emphasis is placed on the roles of these RNPs in the etiology of a genetic disease called Spinal Muscular Atrophy.
Steven Matson Biology, Curriculum in Genetics & Molecular Biology Genetic and biochemical characterization of DNA helicases in E. coli, yeast and flies.
Ann G. Matthysse Biology, Curriculum in Genetics & Molecular Biology There are two ongoing projects in my lab: Mechanism of binding of pathogenic E. coli and Salmonella to plant surfaces and mechanism of cellulose synthesis in bacteria.
Ken McCarthy Curriculum in Neurobiology, Pharmacology Investigating the Role of Astrocyte Signaling in Brain Function.
Gerhard Meissner Biochemistry & Biophysics The goal of the laboratory’s research is to define the structure and function of an intracellular Ca2+ release channel in skeletal and cardiac muscle, using molecular biological and electrophysiological methods and by creating mutant mice.
Karen Mohlke Curriculum in Genetics & Molecular Biology We study how variations in genes lead to common diseases including type 2 diabetes. Approaches include genetic epidemiology, cell biology and mouse models.
A. Leslie Morrow Curriculum in Neurobiology, Curriculum in Toxicology, Pharmacology Function, expression and trafficking GABA-A receptors in the CNS; effects of chronic ethanol exposure that leads to ethanol tolerance and dependence; role of endogenous neurosteroids on ethanol action and adaptations; etiology of essential tremor.

N			Alphabetical Listing Top

Robert A. Nicholas Pharmacology, Curriculum in Neurobiology Our laboratory investigates the cellular and molecular mechanisms by which G protein-coupled receptors and other membrane proteins are differentially targeted to distinct membrane surfaces of polarized epithelial cells.

O			Alphabetical Listing Top

Deborah O’Brien Cell & Developmental Biology, Curriculum in Genetics & Molecular Biology Our lab investigates molecular and cellular mechanisms that regulate mammalian spermatogenesis and fertilization. We use a variety of approaches including molecular biology to analyze novel and developmentally regulated genes, biochemical and immunological methods to examine protein expression, and knockout mice and in vitro assays to determine protein function.
Michael O’Rand Cell & Developmental Biology, Curriculum in Genetics & Molecular Biology Currently, the structure and function of several different sperm and testis proteins are under study. These proteins include: 1) NASP a nuclear protein that binds and transports histone H1 into the nucleus, 2) Sp17 a protein that binds calmodulin and AKAPs, and 3) Eppin a testis and epididymal serine protease inhibitor.
Lawrence E. Ostrowski Cell and Developmental Biology Our research focuses on the role of ciliated airway epithelial cells in health and disease. Project areas include differentiation, gene expression, proteomics, ciliary beat frequency, and gene therapy approaches for cystic fibrosis.
Carol Otey Cell & Molecular Physiology, Curriculum in Neurobiology Mechanisms by which cells control their shape via modulation of the actin cytoskeleton. Palladin, a novel cytoskeletal protein, may be involved in organizing the actin cytoskeleton as a scaffolding protein and may contribute to changes in cell shape.

P			Alphabetical Listing Top

Fernando Pardo-Manuel de Villena Curriculum in Genetics Non-Mendelian genetics including, meiotic drive, parent-of-orifin effects and allelic exclusion.
Leslie Parise Pharmacology, Curriculum in Genetics & Molecular Biology My lab studies the roles of adhesion receptors and intracellular signaling molecules in cardiovascular disease and cancer.
Cam Patterson Cell & Developmental Biology, Pharmacology My laboratory applies integrated molecular, genetic, and physiologic approaches to understand blood vessel development, vascular biology, and stress response pathways in the heart.
Mark Peifer Biology, Curriculum in Genetics & Molecular Biology Cell adhesion, signal transduction, and cytoskeletal regulation during embryogenesis and in cancer. We focus on the regulation of cadherin-based cell-cell adhesion, and on Wnt signaling and its regulation by the tumor suppressor APC. &