 |
Lea
Beaulieu
Department of Pathology of Laboratory
Medicine
942 Mary Ellen Jones Building, CB# 7035
Lab Phone: 966-3313
Lab Fax: 966-7639
|
|
|
|
|
3rd Year IVB Trainee
4th Year Graduate Student
|
|
Ph.D. Project Description:
|
|
Role of the Protein C System
during Breast Cancer Cell Invasion and Endothelial Cell Angiogenesis. |
Principle Investigator: |
|
Professor Frank Church, Ph. D. |
| |
|
IVB Collaborator: |
|
Professor Nobuyo Maeda, Ph.D. |
Project Description: |
|
The Effects of APC on Angiogenesis Using
the Murine Aortic Ring Model. |
| |
|
Rotations: |
|
Dr. Marila Cordeiro-Stone: The Effects of
Caffeine on the Cell Cycle of Human Fibroblasts. |
|
|
Dr. Nobuyo Maedo: Effects of Estrogen on
the Atherosclerotic Plaques of Older Female Mice. |
|
|
Dr. Frank Church: Inhibitory Role of Plasminogen
Activator Inhibitor - 1 (PAI-1) on Activated Protein C (APC) in the Presence
of Vitronectin. |
|
|
Familiar Techniques: |
|
Zymography, Transwell Invasion and Chemotaxis
Assays, In VitroWound-healing Assay, Chromogenic Activity Assays, Tube Formation
Assay |
Other Techniques used in Laboratory: |
|
Protein Kinetics, Kinetic Fluorscopy, Laser-Induced Injury of Wound Healing
Mouse Model |
|
|
|
Undergraduate degree: |
|
B.S. in Biology (2001) from Roanoake College, Salem, VA |
Other Professional/
Graduate degree(s): |
|
Awards/ Scholarships/ Grants/ Fellowships:
|
|
Sykes Fellowship, Alpha Epsilon Lamda Honor Society |
Publications: |
|
Kaufmann, WK, TP Heffernan, LM Beaulieu,
S Doherty, AR Frank, Y Zhour, MF Bryant, T Zhou, DD Luche, N Nikolaishvili-Feinberg,
DA Simpson, and M Cordiero-Stone, L. et al. (2003). Caffeine and human DNA
metabolism: the magic and the mystery. Mutational Research. 532(1-2):
85-102 . |
|
Personal Comments: |
|
|