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Carie
Facemire
Cell and Molecular Physiology
6337 Medical Biomolecular Research Building, CB# 7545
Lab Phone: 919-966-9933
Lab Fax: 919-966-6927
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3rd Year IVB Trainee
5th Year Graduate Student
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Ph.D. Project Description:
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Characterization of store- and receptor-operated calcium influx pathways and canonical transient receptor potential channels in the renal microcirculation |
Principle Investigator: |
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William J. Arendshorst, Ph.D. |
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IVB Collaborator: |
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Project Description: |
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Rotations: |
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William J. Arendshorst, Ph.D.: Characterization of calcium entry pathways in renal interlobular arteries |
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James Faber, Ph.D.: Mechanisms of norepinephrine-induced vascular wall hypertrophy |
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Familiar Techniques: |
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Fura-2 calcium imaging, small animal surgery, isolation and culture of primary vascular smooth muscle cells, real-time RT-PCR |
Other Techniques used in Laboratory: |
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Meausurement of renal blood flow, blood pressure, and glomerular filtration rate in anesthetized animals, immunoblotting |
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Undergraduate degree: |
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B.A. in Biology (1997) from Case Western Reserve University, Cleveland, OH |
Other Professional/
Graduate degree(s): |
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Awards/ Scholarships/ Grants/ Fellowships:
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Caroline tum Suden/Francis Hellebrandt Professional Opportunity Award (American Physiological Society), Aventis Pharmaceutical Excellence in Renal Research Award (American Physiological Society - Renal Section), Dissertation Completion Research Fellowship (UNC-CH), Young Investigator Travel Award (FASEB), International Union of Physiological Sciences Travel Award (XXXV IUPS Congress) |
Publications: |
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Facemire, C., F.V. Brozovich and J.-P. Jin. The maximal velocity of vascular smooth muscle shortening is independent of the expression of calponin. J Muscle Res Cell Motil 21: 367-373, 2000. |
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Zhang, H., C.S. Facemire, A.J. Banes, and J.E. Faber. Different alpha-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro, Am J Physiol Heart |
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Facemire C.S. and W.J. Arendshorst. Calmodulin mediates norepinephrine-induced receptor-operated calcium entry in preglomerular resistance arteries. Am J Physiol Renal Physiol 289: F127-F136, 2005. |
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Facemire C.S., Mohler, P.J., and W.J. Arendshorst. Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation. Am J Physiol Renal Physiol 286: F546-F551, 2004. |
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Personal Comments: |
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