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Tiana Garrett Cell and Developmental Biology Lineberger CCC 12-026, CB# 7295 Lab Phone: Jun-83 Lab Fax: |
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2nd Year IVB Trainee
3rd Year Graduate Student
IBMS |
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Ph.D. Project Description:
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The Role of Vascular Endothelial Growth Factor (VEGF) signaling in the Regulation of Small GTPase Rac1 Exchange Factors | |
Principle Investigator: |
Dr. Keith Burridge | |
IVB Collaborator: |
Dr. Susan Smyth | |
Project Description: |
We plan to use endothelial cells from mice lacking the expression of specific Rac1 exchange factors to determine if they are required for blood vessel formation. | |
Rotations: |
Steve Clarke: The goal of this project was to understand how a protein called the Smith anigen (Sm antigen) initiates abberant B-cell production during an auto-immune response in diseases such as lupus. | |
| Vicki Bautch: The aim of this project was to elucidate how vascular endothelial growth Factor (VEGF) and Sonic Hedgehog (Shh) mediate endothelial cell differentiation and tissue formation during embryogenesis by measuring tissue-specific gene expression with RT-PCR. | ||
| Keith Burridge: In this project, I studied the role of small GTPase RhoA and its downstream effector Rho Kinase (ROCK) on leukocyte transmigration across endothelial lining of blood vessel walls. | ||
Familiar Techniques: |
Western Blotting PCR Immunoflourescence Subclobing and gene expression | |
Other Techniques used in Laboratory: |
Small GTPase Activity Assays Guanine Nucleotide Exchange Factor (GEF) Pulldown Assays Chemotaxis and Migration Assays | |
Undergraduate degree: |
B.S. in Chemistry (2001) from Virginia State University, Petersburg, VA | |
Other Professional/
Graduate degree(s): |
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Awards/ Scholarships/ Grants/ Fellowships: |
American Heart Association Predoctoral Fellowship, Integrative Vascular Biology Predoctoral Training Grant, Ford Foundation Honorable Mention | |
Publications: |
Gullipalli, A., Garrett, T.A.*, Paing, M.M., Griffin, C., Yang, Y. and Trejo, J. A Role for Sorting Nexin 2 in Epidermal Growth Factor Receptor Down-regulation: Evidence for Distinct Functions of Sorting Nexin 1 and 2 in Protein Trafficking (2004). Mol Biol Cell 5, 152143-152155. * Published as co-first author | |
Personal Comments: |
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