Yau-Sheng Tsai

  Biology

701 Brinkhous-Bullitt Bldg., CB# 7525

Lab Phone: 966-6916

Lab Fax: 966-8800
4th Year IVB Trainee
5th Year Graduate Student
 
Ph.D. Project Description:
Peroxisome proliferator-activated receptor gamma in the metabolic syndrome
Principle Investigator:
Nobuyo Maeda
 
IVB Collaborator:
Dr. Rosalind Coleman and Dr. Nobuyuki Takahashi
Project Description:
  
   
Rotations:
  
 
 
 
Familiar Techniques:
  
Other Techniques used in Laboratory:
  
 
Undergraduate degree:
   B.S. in Plant Pathology (4) from National Taiwan University, Taipei, TAIWAN
Other Professional/ Graduate degree(s):
   M.S. in Biochemistry (2) from National Cheng Kung University Medical School, Tainan, TAIWAN

Awards/ Scholarships/ Grants/ Fellowships:

   Honorary member of the Phi Tau Phi Scholastic Honor Society, 1996, American Heart Association Predoctoral Fellowship, 2002~04, Research Presentation Award of Annual Research Symposium, UNC, 2002, National Institutes of Health Scholarship Award, Keystone Symposia, 2003, National Institutes of Health Scholarship Award, Keystone Symposia, 2004
Publications:
   G. Y. Shi, B. I. Chang, S. W. Su, K. C. Young, D. H. Wu, L. C. Chang, Y. S. Tsai, and H. L. Wu. Preparation of a novel streptokinase mutant with improved stability. Thromb. Haemostasis 79, 992-7, 1998.
 
   M. Kakoki, Y. S. Tsai, H. S. Kim, S. Hatada, D. J. Ciavatta, N. Takahashi, L. W. Arnold, N. Maeda, and O. Smithies. Systemic variations in the level of expression of genes by modifying their 3Æ-regions. Developmental Cell. 6, 597-606, 2004.
 
   Y. S. Tsai, H. J. Kim, N. Takahashi, H. S. Kim, J. R. Hagaman, J. K. Kim, and N. Maeda. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J. Clin. Invest. 114, 240~249, 2004
 
   Y. S. Tsai and N. Maeda. PPARgamma: a critical determinant of body fat distribution in humans and mice. Trends in Cardiovascular medicine. (in press)
Personal Comments:
   I joined the Molecular and Cellular Pathology Ph.D. program in the Fall of 2000. I joined the laboratory of Dr. Nobuyo Maeda and Dr. Oliver Smithies in the fall of 2000 and am excited to be part of the "Mouse lab". I am currently working on the gene targeting and animal models for vascular diseases. My research is aimed to understand why the gene defect in peroxisome proliferator-activated receptor-gamma (PPAR-gamma), factor to regulate glucose and lipid homeostasis, can cause different metabolic syndromes and cardiovascular abnormalities, such as atherosclerosis, diabetes mellitus, obesity, and hypertension.