E-mail: gduncan@med.unc.edu
Office Phone: 919-966-8237
Education:
B.S., Biology, Georgia State University
Ph.D., Pharmacology, University of Louisville
Summary Statement:
Dr. Duncan’s research involves behavioral and neurochemical studies in mouse models of psychosis, with the hope of finding new approaches to treat schizophrenia. Another area of work involves neuroscience curriculum development for elementary through high school students.
In basic research studies with antipsychotic drugs, we examine biochemical and behavioral effects of the drugs in animal models. The models are based on manipulation of brain chemistry by drugs and genetic engineering to mimic changes that may occur in schizophrenia. Better understanding of biological abnormalities associated with the models could help define novel and more effective treatment strategies for schizophrenia.
In neuroscience education work, we are developing hands-on activities that use visual arts, drama, and music to make learning fun. We have named this effort the Brain Explorers program and have had great feedback from teachers, parents, and students. Our goal is to create a greater sense of awareness of the biological basis of brain function and behavior, through an enjoyable science learning experience.
Representative Publications:
1. Duncan, G.E. Inada, K., Koller, B.H., Moy S.S. Increased sensitivity to kainic acid in a genetic model of NMDA receptor hypofunction. Brain Research 1307: 166-176, 2010.
2. Duncan, G.E., Inada, K, Farrington, J.S., Koller, B.H., and Moy, S.S. Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress. Brain Research 1265: 186-1955, 2009.
3. Miyamoto, S., Leipzig, J.N., Lieberman, J.A., Duncan, G.E. Effects of ketamine, MK-801, and amphetamine on regional brain 2-Deoxyglucose uptake in freely moving mice. Neuropsychopharmacology 22:400-412, 2000.
4. Moy, S.S., Nadler, J.J., Poe, M.D., Nonneman, R.J., Young, N.B., Koller, B.H. Crawley, J.N., Duncan, G.E., Bodfish, J.W. Development of a Mouse Test for Repetitive, Restricted Behaviors: Relevance to Autism. Behavioral Brain Research 118: 178-194, 2008.
5. Duncan G.E., Moy, S.S., Lieberman, J.A., Koller, B.H. Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function. Psychopharmacology 184: 190-200, 2006.
