Flavio Frohlich, Ph.D.

Office:  4109F Neuroscience Research Building

Email:  flavio_frohlich@med.unc.edu

Phone:  (919) 966-4584

Website:  http://www.frohlichlab.org

Education:

International Diploma, Electrical and Electronic Engineering, Imperial College, London, United Kingdom

Diplom-Ingenieur, Information Technology and Electrical Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland

PhD., Computational Neurobiology, University of California, San Diego & The Salk Institute for Biological Studies

Postdoctoral Fellowship, Neurobiology, Yale University

Summary Statement:

Our goal is to understand cortical network dynamics and to become a key contributor to the fields of network neuroscience and brain stimulation. We combine electrophysiology, computational modeling, and engineering principles to investigate how cortical networks generate physiological and pathological activity states and how perturbations can be used to modulate these states. We aim for a rapid translation of our research into the clinical domain for treatment of patients with psychiatric and neurological disorders.

Representative Publications:

1. Frohlich F, Sejnowski TJ, Bazhenov M. Network bistability mediates spontaneous transitions between normal and pathological brain states. J. Neurosci. 2010 Aug 11;30(32):10734-43.
2. Frohlich F and McCormick DA. Endogenous Electric Fields May Guide Neocortical Network Activity. Neuron. 2010 July; 67(1):129-143.
3. Frohlich F, Bazhenov M, Sejnowski TJ. Pathological effect of homeostatic synaptic scaling on network dynamics in diseases of the cortex. J Neurosci. 2008 Feb 13;28(7):1709-20.
4. Frohlich F, Bazhenov M, Iragui-Madoz V, Sejnowski TJ Potassium Dynamics in the Epileptic Cortex - New Insights on an Old Topic The Neuroscientist. 2008 Oct;14:422-433.
5. Frohlich F, Bazhenov M. Coexistence of tonic firing and bursting in cortical neurons. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep;74(3 Pt 1):031922.