E-mail: bradley_gaynes@med.unc.edu

Phone: (919) 445-0214

Phone (Faculty Practice): (919) 929-7449

Education:

B.A., Brown University, Psychology
Post-Baccalaureate Special Student, Brown University
M.D., University of Virginia School of Medicine
Community Medicine Internship, University of Colorado Health Sciences Center
Residency, Psychiatry, University of Colorado Health Sciences Center
Fellowship, Preventive Medicine, The University of North Carolina at Chapel Hill
M.P.H., School of Public Health, Department of Epidemiology, The University of North Carolina at Chapel Hill
Robert Wood Johnson Clinical Scholar, The University of North Carolina at Chapel Hill

Summary Statement:

Bradley Gaynes MD, MPH, is a Professor and the Associate Chair of Research Training and Education in the Department of Psychiatry at the University of North Carolina at Chapel Hill.  His post-graduate training has included a Robert Wood Johnson Clinical Scholar Fellowship at the University of North Carolina, where he also received his Master of Public Health degree in Epidemiology and completed a fellowship in Preventive Medicine. Dr. Gaynes works at the crossroads between clinical trials research and mental health services research (including comparative effectiveness reviews), and he focuses his clinical and research efforts on treatment resistant depression and on improving the delivery of depression care in non-psychiatric settings, including primary care, obstetrical, and HIV practices.

As a clinical trials researcher, Dr. Gaynes has participated in seminal work on primary care depression management.  He has been funded through an NIMH Career Development Award (K23) from NIMH entitled, "Targeting Treatment Resistant Depression in Primary Care" and  served as the Director of the UNC Regional Center for STAR*D. Currently, Dr. Gaynes is PI on an NIMH-funded R-34 adapting measure-based care to manage depressed HIV patients in Cameroon, and he is co-PI on an NIMH-funded R-01 assessing whether HIV outcomes in depressed HIV patients are better following randomization to measurement-based care compared to usual care.

As a mental health services researcher, Dr. Gaynes has previously served as PI for the U.S. Preventive Services Task Force's evidence report on screening for suicide risk in primary care; as co-investigator on a Task Force report on screening for depression in primary care; and as PI on a recently completed AHRQ-funded comparative effectiveness review of the effectiveness of nonpharmacologic interventions in the management of treatment refractory depression.  He is currently an investigator on the UNC/RTI collaborative project, “Comprehensive EPC Comparative Effectiveness Reviews for Effective Health Care”.

Representative Publications:

1. O’Connor E, Gaynes BN, Burda BU, Williams C, Whitlock EP. Screening for Suicide Risk in Primary Care: A Systematic Evidence Review for the U.S. Preventive Services Task Force. Annals Internal Med. 23 April 2013 [Epub ahead of print]
2. Gaynes BN, Pence BW, Atashili J, O'Donnell J, Kats D, Ndumbe PM. Prevalence and Predictors of Major Depression in HIV-Infected Patients on Antiretroviral Therapy in Bamenda, a Semi-Urban Center in Cameroon. PLoS ONE, 2012. 7(7): p. e41699.
3. Gaynes BN, Lux LJ, Gartlehner G. Primary Care Depression Guidelines and Treatment Resistant Depression: Variations on an Important but Understudied Theme (invited commentary). In: National Guideline Clearinghouse (NGC) (2012). Rockville (MD): Agency for Healthcare Research and Quality (AHRQ).
4. Gaynes BN, Dusetzina SB, Ellis AR, Hansen RA, Farley JF, Miller WC, Stürmer T. Treating Depression After Initial Treatment Failure: Directly Comparing Switch and Augmenting Strategies in STAR*D. J Clin Psychopharmacol. 2012: 32(1): 114-119. PMID:22198447
5. Gaynes BN, Lux L, Lloyd S, Hansen RA, Gartlehner G, Thieda P, Brode S, Swinson Evans T, Jonas D, Crotty K, Viswanathan M, Lohr KN. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33. (Prepared by RTI International-University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016I.) AHRQ Publication No. 11-EHC056-EF. Rockville, MD: Agency for Healthcare Research and Quality. September 2011.