Linmarie Sikich, M.D.

Email:  linmarie_sikich@med.unc.edu

Phone:  (919) 966-8653

Education:

B.A., English, Washington University

M.A., Neurobiology, Washington University

M.D., Washington University

Postdoctoral Research Fellowship, Psychiatry, Washington University

Resident, Psychiatry, Yale University

Clinical Child Psychiatry Fellowship, Psychiatry, Yale Child Study Center

Fellowship, Child Psychiatry Research Training Program, Yale Child Study Center

Summary Statement:

Since joining the UNC-CH faculty, Dr. Sikich has become interested in early onset psychotic illnesses. Previously, during her child psychiatry research training fellowship at Yale Child Study Center she focused upon autism spectrum disorders. Today, the majority of her work is focused on evaluating and developing treatments for severe neurodevelopmental disorders such as autism and schizophrenia using standard efficacy measures, effectiveness measures that also consider the tolerability and acceptability of treatments, and neurocognitive outcomes. She is interested in genetic factors that may influence treatment response. Her research on treatments for autism and schizophrenia spectrum disorders in children and adolescents is funded by the National Institutes of Mental Health.

Representative Publications:

1. Maynard TM, Sikich L, Lieberman JA, LaMantia A-S. Neural development, cell-cell signaling and the “two-hit” hypothesis of schizophrenia. Schizophrenia Bulletin; 27(3):457-476, 2001.
2. Sikich L, Hamer RA, Bashford RA, Sheitman BB, Lieberman, JA. Antipsychotic treatment of psychotic children and adolescents: a double-blind comparison of risperidone, olanzapine, and haloperidol. Submitted to Archives of General Psychiatry 18 pages.
3. Schur SB, Sikich L, Findling R, Malone RP, Crismon ML, Derivan A, MacIntyre JC, Pappadopulos E, Greenhill L, Schooler N, Van Orden K, Jensen PS (In Press). Treatments recommendations for use of antipsychotics for aggressive youth part one: review of relevant literature. Journal of the American Academy of Child and Adolescent Psychiatry, 39 pages.
4. Sikich L, Hamer R, Malekpour AH, Ekstrom DS, Jackson CS, Hughes J, Mendel CP, Brooks TS, White R, Bashford RA, Sheitman BB, Lieberman JA. Double-blind trial comparing risperidone, olanzapine, and haloperidol in psychotic children and adolescents. Biological Psychiatry; 51 (8S):217, 2002;.
5. Sikich L, Barnhill LJ. Evaluation of the Adult Mentally Retarded Patient in the Emergency Department. In: Tintanelli J, Kelen GD, Stacyplski JS eds. Emergency Medicine: A Comprehensive Study Guide, Fifth Edition. New York, NY: McGraw Hill; 2009-2014, 2000.