David R. Rubinow, M.D.

Assad Meymandi Distinguished Professor and Chair of Psychiatry

 

David R. Rubinow, M.D.

 

E-mail:  drubinow@med.unc.edu

Office: 304 MacNider Hall

Phone: (919) 445-0208

Fax: (919) 445-0234

 

Education:

B.A., with distinction, University of Michigan
M.D., University of Connecticut School of Medicine
Internship and Residency in Psychiatry, Yale University

 

Positions Held:

Clinical Director, National Institute of Mental Health
Clinical Professor of Psychiatry, Georgetown University School of Medicine
Chief, Behavioral Endocrinology Branch, NIMH

 

Summary Statement:

Dr. Rubinow's research interests have focused largely on the neurobehavioral effects of gonadal steroids.  He has pursued these interests by employing hormone superagonists and receptor blockers to manipulate the menstrual cycle in order to identify the central effects of gonadal steroids in isolation.  He has performed similar endocrine manipulation studies in perimenopausal women and, more recently, in men.  Dr. Rubinow's laboratory investigates sexual dimorphisms in neuronal and glial signal transduction as well as strain differences in behavioral sensitivity to gonadal steroids.  Gene-based haplotyping of candidate genes is performed in the clinical laboratory as part of his major research effort - the attempt to identify factors accounting for the differential response across individuals to what is ostensibly the same stimulus.

Dr. Rubinow has received awards for his research (e.g., the A. E. Bennett Neuropsychiatric Research Foundation Award; the Research Award of the Academy of Psychosomatic Medicine; the Gold Medal Award of the Society of Biological Psychiatry; the Mood Disorders Research Award of the American College of Psychiatrists; and the William C. Menninger Memorial Award of the American College of Physicians), his clinical supervision and training (the NIH Distinguished Clinical Educator Award and the NIMH Mentor of the Year [2002]), and his scientific administration (the USPHS Outstanding Service Medal).

He is a member of a number of professional organizations, including the Endocrine Society, the American College of  Neuropsychopharmacology, of which he is the 2009 President-elect, the American Neuroendocrine Society, and the Society of Biological Psychiatry, which he served as President.  He currently serves on the editorial boards of six journals and has authored or co-authored more than 300 scientific publications.

 

Representative Publications:

  1. Rubinow DR.

    Antidepressant treatment during pregnancy: between Scylla and Charybdis. 
    Am J Psychiatry. 2006 Jun;163(6):954-6.

  2. Rubinow DR, Schmidt PJ.

    Gonadal steroid regulation of mood: the lessons of premenstrual syndrome. 
    Front Neuroendocrinol. 2006 Jul;27(2):210-6. Epub 2006 May 2.

  3. Bloch M, Rubinow DR, Berlin K, Kevala KR, Kim HY, Schmidt PJ.

    Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men.
    Arch Gen Psychiatry. 2006 Apr;63(4):450-6.

  4. Rubinow DR.

    Treatment strategies after SSRI failure--good news and bad news.
    N Engl J Med. 2006 Mar 23;354(12):1305-7.

  5. Schmidt PJ, Cardoso GM, Ross JL, Haq N, Rubinow DR, Bondy CA.

    Shyness, social anxiety, and impaired self-esteem in Turner syndrome and premature ovarian failure.
    JAMA. 2006 Mar 22;295(12):1374-6.