Functional imaging group

Neurobiology of Selective Attention , 1R01MH58251-01A3, PI (NIMH), through 2012
The clinical objective of the proposed studies is to relate selective attention deficits in schizophrenia to symptomatology and chronicity of this illness.

Human Functional Brain Anatomy (PPG), 1P01NS41328-01, PI (NINDS), through 2006
This Program Project will investigate the functional neuroanatomy of the human brain using high-field functional magnetic resonance imaging (functional MRI). The four scientific projects are strongly linked by their focus on the relationship between brain and behavior. The projects are organized into a logical progression from sensory processing through response.

Prospective Studies of the Pathophysiology of schizophrenia, UNC Silvio O. Conte Center, 5R01 MH61603, Co-investigator, through 6/2007
The goal of this project is to identify pathogenic mechanisms in schizophrenia and related psychotic disorders using targeted gene strategies to develop animal models and neurobiologic studies of high risk human subjects.

Child Development and Mental Retardation Core - Developmental Neuroimaging, 5 P30 HD03110, Core PI (NICHD), through 2007
The goal of this project is to provide educational, technical, training, and environmental support and resources for all projects in the Neurodevelopmental Disorders Research Center (NDRC) that have or plan on having a neuroimaging data acquisition or data analysis component.

FIRST BIRN (Biomedical Informatics Resource Network), Sub-Investigator (NIH), through 2011
The goal of this grant is to fund a national infrastructure for large scale, multi-center studies of brain functions using functional magnetic resonance imaging (fMRI).

Gene-Brain-Behavior in Autism, 1 U54 MH066418-01, Project PI (NIH/NIMH), through 2007
This grant focuses on conducting fMRI/Longitudinal MRI studies of social/affective processes and executive function/ritualistic-repetitive behaviors in adults and very young children with autism.

Foundation

Multimodal Imaging of fronto-striate circuits in inviduals at Ultra High-risk for schizophrenia: In search of intermediate phenotypes, NARSAD Independent Investigator Award (PI), through 2006
The goal of this study is to use Functional Magnetic Resonance Imaging (fMRI) to characterize cortical pathology associated with the ultra high-risk for schizophrenia in prodromal and sympotomatic individuals to identify measures that can be used for early intervention strategies designed to prevent the onset of schizophrenia.

The role of dopamine in normal brain function, Foundation of Hope (PI), through 2007
This grant will use Functional Magnetic Resonance Imaging (fMRI) to characterize to understand the dopamine effects in normal healthy subjects.

Risperidone effects on frontal and temporal cortical function in schizophrenia patients undergoing fMRI cognitive performance, JANSSEN Pharmaceuticals (PI), open ended
For this project, we will compare the therapeutic efficacy of Risperidone and Olanzapine and the potential for neuroprotection in psychosis patients using measures of outcome such as psychopathology, neurocognition and MRI.