Study Publications
| Antipsychotics and Weight Gain | | • | Graham KA, Perkins DO, Edwards LJ, Barrier RC, Lieberman JA, Harp JB: Effect of Olanzapine on body composition and energy expenditure in adults with first episode psychosis. American Journal of Psychiatry162(1):118-23, Jan 2005. PMID: 15625209
| | • | Zipursky RB, Gu H, Green AI, Perkins DO, Tohen MF, McEvoy JP, Strakowski SM, Sharma T, Kahn RS, Gur RE, Tollefson GD, Lieberman JA: Course and predictors of weight gain in people with first-episode psychosis treated with olanzapine or haloperidol. Br J Psychiatry 2005, Dec;187:537-43. PMID: 16319406
| | • | Graham KA, Hongbin G, Lieberman JA, Harp JB, Perkins DO: Double blind placebo controlled investigation of amantadine for weight loss in subjects who have gained weight during treatment with olanzapine. American Journal of Psychiatry 2005;162:1744-1746. PMID: 16135638
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| | First Episode Studies | | • | Perkins DO: Predictors of Non-Compliance in Patients with Schizophrenia. Journal of Clinical Psychiatry 63:12,1121-1128, 2002. PMID: 12523871
| | • | Lieberman JA, Tollefson G, Tohen M, Green AI, Gur RE, Kahn R, McEvoy J, Perkins DO, Sharma T, Zipursky R, Wei H, Hamer R: Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: A randomized double-blind trial of olanzapine vs. haloperidol. American Journal of Psychiatry,160(8):1396-1404, 2003. PMID: 12900300
| | • | Perkins DO, Lieberman JA, Gu H, Tohen M, McEvoy J,Green AI, Zipursky RB, Strakowski SM, Sharma T, Kahn RS, Gur R, Tollefson G, and the HGDH Research Group. Predictors of antipsychotic treatment response in patients with first episode schizophrenia, schizoaffective, and schizophreniform disorders. British Journal of Psychiatry, 185:18-24, 2004. PMID: 15231551
| | • | Judge AM, Perkins DO, Nieri J, Penn DL: Pathways to Care in First Episode Psychosis: A Pilot Study on Help-seeking Precipitants and Barriers to Care. Journal of Mental Health, Brief report,Vol 14(5) 465:469, 2005.
| | • | Pinkham A, Penn DL, Wangelin B, Perkins DO, Gerig G, , Gu H, Lieberman JA: Facial Emotion Perception and Fusiform Gyrus Volume in First Episode Schizophrenia. Schizophrenia Research Vol 79/2-3, 341:343, 2005. PMID: 16125902
| | • | Lieberman JA, Tollefson G, Charles C, Zipursky R, Sharma T, Kahn R, Keefe R, Green AI, Gur RE, McEvoy J, Perkins DO, Hamer RM, Gu H, Tohen M, and HGDH Research Group: Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis. Archives of General Psychiatry 2005 Apr;62(4):361-70. PMID: 15809403
| | • | Perkins DO, Gu H, Boteva K, Lieberman JA: Duration of Untreated Psychosis and Outcome in Schizophrenia. American Journal of Psychiatry 2005; 162:1785-1804. PMID: 16199825
| | • | Perkins DO, Johnson J, Hamer R, Zipursky R, Keefe R, Centorrhino F, Green A, Glick I, Kahn R, Sharma T, Tohen M, McEvoy JP, Weiden P, Lieberman JA, and the HGDH Research Group: Predictors of Antipsychotic Medication Adherence in Patients Recovering from a First Psychotic Episode. Schizophrenia Research, 2006 Mar 1;83(1):53-63. Epub 2006 Mar 9. PMID: 16529910
| | • | Green AI, Lieberman JA, Hamer RM, Blick ID, Gur RE, Kahn RS, McEvoy JP, Perkins DO, Rothschild AJ, Sharma T, Tohen MF, Woolson S, Zipursky RB, HGDH Study Group. Olanzapine and haloperidol in first episode psychosis: two-year data. Schizophr Res. 2006 Sep;86(1-3):234-43. Epub 2006 Aug 2. PMID: 16887334
| | • | Perkins DO: Review: longer duration of untreated psychosis is associated with worse outcome in people with first episode psychosis. Evid Based Ment Health. 2006 May;9(2):36. PMID: 16638885
| | • | McEvoy JP, Lieberman JA, Perkins DO, Hamer RM, Gu H, Lazarus A, Sweitzer D, Olexy C, Weiden P, Strakowski S. Efficacy and Tolerability of Olanzapine, Quetiapine, and Risperidone in the Treatment of Early Psychosis: A Randomized, Double-Blind, 52-Week Comparison. Am J Psychiatry. 2007 Jul;164(7):1050-60. PMID: 1760665.
| | • | Keefe RSE, Sweeney JA, Gu H, Hamer RM, Perkins DO, McEvoy JP, Lieberman JA. Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in first-episode psychosis: a randomized, double-blind 52-week comparison. Am J Psychiatry 2007 Jul;164(7):1061-71. PMID: 17606658
| | • | Judge AM, Estroff SE, Perkins DO, Penn DL. Recognizing and responding to early psychosis: a qualitative analysis of individual narratives. Psychiatr Serv. 2008 Jan;59(1):96-9. PMID: 18182546
| | • | Perkins DO, Gu H, Weiden PJ, McEvoy JP, Hamer RM, Lieberman JA on behalf of the CAFÉ study group. Predictors of Treatment Discontinuation and Medication Non-Adherence in Patients Recovering from a First Episode of Schizophrenia, Schizophreniform Disorder, or Schizoaffective Disorder: A Randomized, Double-Blind, Flexible-Dose Multicenter Study. Journal of Clinical Psychiatry, 2008;69;1:106-113. PMID: 18092883
| | • | Uzenoff R, Perkins DO, Hamer RM, Weisen CA, Penn DL. A Preliminary Trial of Adherence-Coping-Education (ACE) Therapy for Early Psychosis. Brief Report, Journal of Nervous and Mental Disease 2008 Jul;196(7):572-575. PMID: 18626299
| | • | Couture SM, Penn DL, Addington J, Woods SW, Perkins DO. Assessment of social judgements and complex mental states in the early phases of psychosis. Schiz Res. 2008 Mar;100(1-3):237-41. Epub Feb 5. PMID: 18255273. PMC2366051 [Available on 03/01/09].
| | • | Waldheter EJ, Penn DL, Perkins DO, Mueser KT, Owens LW, Cook E. The Graduated Recovery Intervention Program for First Episode Psychosis: Treatment Development and Preliminary Data. Community Mental Health J. 2008 Dec;44(6):443-55. Epub 2008 May 31.PMID: 18516680. NIHMS # 53384
| | • | Thompson PM, Bartzokis G, Hayashi KM, Klunder AD, Lu PH, Edwards N, Hong MS, Yu M, Geaga JA, Toga AW, Charles C, Perkins DO, McEvoy J, Hamer RM, Tohen M, Tollefson GD, Lieberman JA; The HGDH Study Group. Time-Lapse Mapping of Cortical Changes in Schizophrenia with Different Treatments. Cereb Cortex. 2009 May;19(5):1107-23. 2008 Oct 8; [Epub ahead of print] PMID: 18842668
| | • | Patel JK, Buckley PF, Woolson S, Hamer RM, McEvoy JP, Perkins DO, Lieberman JA, For The Cafe Investigators. Metabolic profiles of second-generation antipsychotics in early psychosis: Findings from the CAFE study. Schizophr Res. 2009 Jun;111(1-3):9-16. Epub 2009 Apr 26. PMID: 19398192
| | • | Uzenoff SR, Brewer KC, Perkins DO, Johnson DP, Mueser KT, Penn DL. (in press). Psychological well-being among individuals with first episode psychosis. Early Interv Psychiatry. 2010 May:4(2):174-81. PMID: 20536974
| | • | Gibson CM, Penn DL, Prinstein MJ, Perkins DO, Belger A. Social skill and social cognition in adolescents at genetic risk for psychosis. Schizophr Res. 2010 May 28. [Epub ahead of print] PMID: 20570111
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| | Psychosis Risk Syndrome | | • | Heinssen RK, Perkins DO, Appelbaum PS, Fenton WS: Informed consent in early psychosis research. National Institute of Mental Health Workshop, November 15, 2000. Schizophrenia Bulletin 27(4):571-583, 2001. PMID: 11824484
| | • | Woods SW, Breier A, Zipursky RB, Perkins, DO, Addington J, Miller TJ, Hawkins KA, Marquez E, Lindborg SR, Tohen M, McGlashan TH: Randomized Trial of Olanzapine vs Placebo in the Symptomatic Acute Treatment of the Schizophrenic Prodrome. Biological Psychiatry, Aug 15;5(4):453-464. Erratum in: p. 497, 2003. PMID: 12915290
| | • | McGlashan TH, Zipursky RB, Perkins DO, Addington, J, Miller TJ, Woods SW, Hawkins KA, Hoffman R, Lindborg S, Tohen M, Breier A: The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis, I. Study rationale and design. Schizophrenia Research 61:7-18, 2003. PMID: 12648731
| | • | Miller T, Zipursky RB, Perkins DO, J. Addington J, Woods SW, Hawkins KA, Hoffman R, Preda A, Epstein I, Addington D, Lindborg S, Marques E, Tohen M, Breier A, McGlashan TH: The PRIME North America Randomized Double-Blind Clinical Trial of Olanzapine Versus Placebo in Patients at Risk of Being Prodromally Symptomatic for Psychosis: II. Baseline Characteristics of the “Prodromal” Sample. Schizophrenia Research 16;19-30, 2003. PMID: 12648732
| | • | Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Ventura J, McFarlane W, Perkins DO, Pearlson GD, Woods SW: Prodromal Assessment With the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive Validity, Interrater Reliability, and Training to Reliability. Schizophrenia Bulletin, 29(4):703-715, 2003. PMID: 14989408
| | • | Hawkins KA, Addington J, Keefe RS, Christiansen B, Perkins DO, Zipursky R, Woods SW, Miller TJ, Marquez E, Breier A, McGlashan TH: Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophrenia Research Apr 1;67(2-3):115-22, 2004. PMID: 14984870
| | • | Hawkins KA, McGlashan TH, Quinlan D, Miller TJ, Perkins DO, Zipursky RB, Addington J, Woods SW: Factorial Structure of the Scale of Prodromal Symptoms. Schizophrenia Research June 1:68(2-3):339-47, 2004. PMID: 15099615
| | • | Morey RA, Inan S, Mitchell TV, Perkins DO, Lieberman JA, Belger A: Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing.
Arch Gen Psychiatry. 2005 Mar;62(3):254-62. PMID: 15753238
| | • | McGlashan TH, Zipursky R, Perkins DO, Addington J, Miller T, Woods S, Kawking K, Hoffman R, Preda A, Epstein I, Addington D, Lindborg S, Trzaskoma Q, Tohen M, Breier A: The PRIME North America Randomized, Double-Blind Clinical Trial of Olanzapine Versus Placebo in Patients at Risk of Being Prodromally Symptomatic for Psychosis: Efficacy and Safety Results of the Double-Blind and No-Treatment Follow-Up Periods. American Journal of Psychiatry, 2006 May;163(5):790-9. PMID: 16648318
| | • | Keefe RSE, Perkins DO, Gu H, Zipursky RB, Christensen BK, Lieberman JA. A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophr Res. 2006 Dec;88(1-3):26-35. Epub 2006 Aug 22. PMID: 16930949
| | • | Pinkham AE, Penn DL, Perkins DO, Graham KA, Siegel M. Emotion Perception and Social Skill over the Course of Psychosis: A Comparison of Individuals “At-risk” for Psychosis and Individuals with Early and Chronic Schizophrenia Spectrum Illness. Cognitive Neuropsychiatry, 2007 May;12(3):198-212. PMID: 17453901
| | • | Addington, J, Cadenhead KS, Cannon TD, Cornblatt B, McGlashan TH, Perkins DO, Seidman LF, Tsuang M, Walker EF, Woods SW, Heinssen R. North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research. Schizophr Bull. 2007 May;33(3):665-72. Epub 2007 Jan 25. PMID: 17255119
| | • | Addington J, Penn DL, Woods SW, Addington D, Perkins DO. Social functioning in individuals at clinical high risk for psychosis. Schizophrenia Research, 2007 Nov 13 [Epub ahead of print]. PMID: 18023329. NIHMS #52731
| | • | Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E, Seidman LJ, Perkins DO, Tsuang M, McGlashan T, Heinssen R. Prediction of Psychosis in Youth at High Clinical Risk: A Multi-Site Longitudinal Study in North America. Archives of General Psychiatry. 2008; 65(1):28-37. PMID: 18180426
| | • | Perkins DO, Gu H, Weiden PJ, McEvoy JP, Hamer RM, Lieberman JA on behalf of the CAFÉ study group. Predictors of Treatment Discontinuation and Medication Non-Adherence in Patients Recovering from a First Episode of Schizophrenia, Schizophreniform Disorder, or Schizoaffective Disorder: A Randomized, Double-Blind, Flexible-Dose Multicenter Study. Journal of Clinical Psychiatry, 2008;69;1:106-113. PMID: 18092883
| | • | Hawkins KA, Keefe RS, Christensen BK, Addington J, Woods SW, Callahan J, Zipurksy RB, Perkins DO, Tohen M, Breier A, McGlashan TH. Neuropsychological course in the prodrome and first episode of psychosis: Findings from the PRIME North America Double Blind Treatment Study. Schizophr Res. 2008 Oct;105(1-3):1-9. Epub 2008 Sep 6. PMID: 18774696
| | • | Woods SW, Addington J, Cadenhead KS, Cannon TD, Cornblatt BA, Heinssen R, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH. Validity of the Prodromal Risk Syndrome for First Psychosis: Findings From the North American Prodrome Longitudinal Study.Schizophr Bull. 2009 Sep;35(5):894-908. Epub 2009 Apr 21. [Epub ahead of print] PMID: 19386578
| | • | Walker EF, Cornblatt BA, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Woods SW, Heinssen R. The relation of antipsychotic and antidepressant medication with baseline symptoms and symptom progression: A naturalistic study of the North American Prodrome Longitudinal Sample. Schizophr Res. 2009 Nov;115(1):50-7. Epub 2009 Aug 25. PMID: 19709859
| | • | Marks C, Penn DL, Prinstein MJ, Serrano D, Perkins DO, Belger A. (in press). An investigation of social skill and social cognition in adolescents at genetic risk for psychosis. Schizophrenia Research.
| | • | Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF, Woods SW, Bearden CE, Christensen BK, Hawkins K, Heaton R, Keefe RS, Heinssen R, Cornblatt BA; for the North American Prodrome Longitudinal Study (NAPLS) Group. Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Arch Gen Psychiatry. 2010 Jun;67(6):578-588. PMID: 2053000
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