Clinical Research STUDIES at Central Regional Hospital

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The research studies at the Central Regional (formerly Dorothea Dix) CRU target chronic stages of psychotic disorders. Below are the names and brief descriptions of each study.  If you see a study that may apply to you, click on the link and get further details on the study and contact information.

COPE - UNC Center for Excellence in Community Mental Health Consultation Outcomes Project

The purpose of this study is to assess the impact of psychiatric consultations and associated recommendations on symptoms, treatment cost, course of treatment, service utilization, and general functioning of individuals diagnosed with a serious mental illness including: schizophrenia or a related psychotic disorder, bipolar illness, or major depression. Read more >>

Ages: 18+

OTS Study - Oxytocin Treatment of Schizophrenia

This is a randomized, double-blind, placebo-controlled study to compare the effects of two weeks of daily administration of oxytocin vs. placebo on social cognition, paranoia and other psychotic symptoms, and social competence in patients with schizophrenia. This is a single-site pilot study for inpatients or outpatients, ages 18-55 years, meeting DSM-IV criteria for schizophrenia, paranoid or undifferentiated type, who have been diagnosed > 1 year, and on the same psychotropic medication(s) and dose(s) for at least one month.

Ages: 18-55

TOPS - Treatment Of Psychotic Symptoms in patients with Major Depressive Disorder with Psychotic Features

This is a double-blind, placebo-controlled study of the efficacy and safety of CORLUX (Mifepristone) versus placebo in the treatment of psychotic symptoms in patients with Major Depressive Disorder with Psychotic Features.  Read more >>

Ages: 18-75