A study that explores three different ways to try to reduce the weight gain caused by antipsychotic medications. Children and adolescents, ages 8-19, who have gained lots of weight while taking iloperidone (Fanapt®), lurasidone (Latuda®), asenapine (Saphris®), aripiprazole (Abilify®), olanzapine (Zyprexa®), quetiapine (Seroquel®), risperidone (Risperdal®), ziprasidone (Geodon®), paliperidone (Invega®), and/or fluoxetine/olanzapine (Symbyax®) are eligible. The ways we are trying to reduce weight are healthy lifestyle guidance, change of medication and/or addition of metformin, a medication that helps the body use insulin better.
We have a new clinical research study that is now ready to enroll for children with Autism, Asperger’s Disorder and PDD-NOS. The purpose of this study is to see if an investigational drug is safe and may help with some of the core symptoms of autism. Participants will receive active study drug for up to 48 weeks and may be eligible to participate in follow-up research studies.
The purpose is to examine whether lurasidone (Latuda©) induces weight gain in children and adolescents ages 6-19. Participants must not have taken certain medications that are similar to Lurasidone (Latuda®) for more than 4 weeks. Similar medications include Risperdal®, Abilify®, Zyprexa®, Seroquel®, Geodon®, and Invega®.
A research study involving children and adolescents (ages 6 - 18 years) with a diagnosis of an autism spectrum disorder. This study is looking at the effects of an investigational medication on the brain. Oxytocin (nasal spray) is thought to help with social behaviors. This study is looking specifically at the effects of oxytocin vs. placebo on various brain activities. Participants will receive either one dose of oxytocin or one dose of placebo (saline solution with no medicine) followed by brain scans and behavioral assessments.