Perimenopausal Research Study

The UNC Center for Women’s Mood Disorders offers research programs to address and explore the needs of women in different stages of menopause. We are currently focusing much of our research on the cardiovascular and psychological effects that occur during this transition. Please click on the PERT study logo to view our brochure.

PERT logo


Perimenopausal Estrogen Replacement Therapy Study

The purpose of this research study is to examine the predictors of the beneficial effects of estrogen replacement therapy (ERT) on depressive symptoms and cardiovascular health during the menopause transition. There is evidence that a history of depression before menopause will predict both the course of depressive symptoms and cardiovascular risk during the menopause transition. A history of depression may also predict the benefits of ERT in perimenopausal women. Click here for the study brochure.


You may be eligible to participate in the PERT research study if you are:

1) Between the ages of 45 and 60

2) Medically healthy

3) Not currently taking antidepressant medication

4) Experiencing symptoms of the transition to menopause, such as irregular or absent cycles, hot flashes, etc,


Eligible women will be randomly assigned (i.e., by chance) to either transdermal ERT (a skin patch containing 17b-estradiol) or placebo (a skin patch containing an inert substance).

Participants will be involved in the study for 12 months. Four visits to UNC will be necessary over the 12-month period.

Not only can you help contribute to medical knowledge for other women like yourself, but you will also receive free study-related medical examinations and be compensated for your time. You will receive:

- Up to $1,525 in compensation for completing the full 12-month enrollment protocol

- Free screening mammogram

- Free gynecological exam

- Free medical screenings, including monitoring of glucose and lipid levels

- Educational materials regarding health and well-being


For more information or to see if you are eligible for the PERT study, please call our study coordinator at (919) 972-7485, email, or visit


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