PMDD Research

UNC Center for Women’s Mood Disorders has research studies available for women struggling with severe premenstrual symptoms. These studies offer free diagnostic evaluation and, for those who qualify, free study-related treatment and/or monetary compensation. All studies are intended to investigate the causes of PMDD and will help guide the development of future treatment interventions.


Get involved in PMDD Research!

Read about new findings by UNC experts:

News Article: Oral Contraceptives May Ease Suffering of Women with Severe PMS
News Article: Researchers at UNC find hereditary link to PMDD
News Article: Abused women appear to suffer cyclic disorder differently

Current Research Studies at UNC


Menstrually-Related Mood Disorders Screening

If you suffer during the week before menstruation from depression, irritability, anxiety or mood swings, and these symptoms interfere with normal functioning or interpersonal relationships, then you may have a menstrually=related mood disorder such as premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD). You may receive diagnostic feedback on your symptoms and study-related medical evaluations in this study.

For women who think they may have PMDD and wish to be evaluated for it.

You may qualify if you:
1) have mood symptoms only premenstrually and not after the end of menstruation pmdd 2
2) are medically healthy and not currently suffering from some other chronic psychiatric condition
3) are 18 – 50 years of age with regular menstrual cycles
4) are not taking any medications, including antidepressants and birth control pills

Women diagnosed in this study with PMS or PMDD may then be eligible to participate in other research studies designed to give treatment and/or monetary compensation.

Watch this video
Please call (919) 966-2547 or email khanh_nguyen@med.unc.edu for more information.


Wellness Intervention for Menstrual Moods (WIMM Study)

The purpose of the WIMM Study is to compare two behavioral interventions for PMDD. Both of these interventions will be run in a group format, meaning that you will be part of a group of other women who have a menstrual mood disorder. Both of these interventions will be run by experienced mental health professionals and both interventions have been shown to be effective in reducing mood symptoms, increasing a sense of well-being, reducing pain, and helping individuals cope with stress. So while we expect both interventions to be associated with some benefit, this research study is designed to see which is better for women with a menstrual mood disorder.

You may qualify if:
1) you have severe PMS or PMDD as determined in the Screening Study described above
2) you are 18 – 55 years of age and medically healthy
3) you are not pregnant or breastfeeding
4) you do not currently suffer from a pain disorder

Women will receive up to $1,668 in compensation.

Please contact Khanh at 919-966-2547 or khanh_nguyen@med.unc.edu for more information.

News article about previous research studies: Trial: Oral Contraceptives May Ease Suffering of Women with Severe PMS


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