David Henke

David Henke

Research Interests

The goal for my clinical work, research and teaching has focused on providing care, developing innovative approaches to treating patients and developing ways to maintain health.  My work in the laboratory has focused on understanding the role of host inflammatory responses in chronic diseases.  This has led me to a novel approach for treating alveolar hemorrhage using Activated Factor VII (rFVIIa).  My main focus has been to understand how the normal airway protects itself, with the goal of developing insight into the molecular basis for chronic inflammatory lung conditions, such as cystic fibrosis (CF), asthma, chronic obstructive pulmonary disease (COPD) and lung transplant graft failure.  I have filed 2 patents:  Moli1901 (1996), a protein used in cystic fibrosis to aid in mucus clearance; and an inhaled therapy (provisional patent filed 2012) currently under testing to use in a variety of chronic bronchitis (CF, asthma COPD and lung transplant).

 

Education:

B.S., University of Maryland, College Park, MD (1969)

MPH, University of North Carolina, Chapel Hill, NC (1973)

Public Health Honorary Delta Omega

MD, University of North Carolina, Chapel Hill, NC (1977)

King Edward's Fund Fellow (1974)

Residencies:

Internal Medicine (1980)

University of North Carolina, Chapel Hill, NC

Dermatology (1982)

University of North Carolina, Chapel Hill, NC

Pulmonary (1985)

University of North Carolina, Chapel Hill, NC

Chief Pulmonary Fellow (1985-1986)

Boards:

American Board of Internal Medicine (1980)

American Board of Dermatology (1983)

American Board of Pulmonary Medicine (1988)

American Board of Critical Care (1992)

Awards:

America’s Top Doctors, US News and World Report (2001—2013)

Best Doctors in America (2009—2012)

National Physician of the Year Award (2008)

Phoenix Award, collaborator (2006)
UNC was awarded the first Phoenix Award by the American Academy of Allergy, Asthma, and Immunology

Strathmore’s WHO’S WHO (2003-2004)

Better Performer (1998)

University Healthcare Consortium for Ambulatory Care Management Excellence

Previous Positions:

Associate Professor of Medicine, Division of Pulmonary Diseases (1998—present)

University of North Carolina, Chapel Hill, NC

Project Manager and Co-developer of Renaissance Computing Institute (RENCI) (2006—2008)

University of North Carolina, Chapel Hill, NC

Cited in Moeser, James. Carolina North Holds Promise”, Our Community.  March 2007.

“…a great example of how Carolina North could enhance the university's mission of discovering new ways to improve people's lives.”

Medical Director for Ambulatory Care for UNC Health Care System (1998 – 2001)

University of North Carolina at Chapel Hill, Chapel Hill, NC

Associate Chair for Ambulatory Medicine (1997 – 2001)

University of North Carolina at Chapel Hill, Chapel Hill, NC

Assistant Professor of Medicine, Division of Pulmonary Diseases (1992 – 1998)

University of North Carolina, Chapel Hill, NC

Medical Director of Ambulatory Operations for the Dept. of Medicine (1991 – 2001)

University of North Carolina, Chapel Hill, NC

Research Assistant Professor, Division of Pulmonary Diseases (1986 – 1992)

University of North Carolina, Chapel Hill, NC

Pulmonary Research Scientist, NIEHS/Clinical Instructor (1983 – 1984)

University of North Carolina, Chapel Hill, NC

Peace Corps

Chemistry and Physics High School Teacher (1969 – 1970)

Zomba, Malawi, Africa

Mental Hospital Assistant, Malawi Mental Hospital (1970 – 1971)

Zomba, Malawi, Africa

Evaluated Parasite Eradication Project (1971 – 1972)

Vanga Mission Station, Democratic Republic of the Congo, Africa

Patents

Inhalant treatment of bacteria-mediated inflammatory airway diseases (provisional status) (2012)

Method of treating retained pulmonary secretions (US Patent 5,512,569) (1993)

Selected Publications:

Henke D, Crockett S, et al. Clinical Trial: High-Dose Acid Suppression for Chronic Cough: A Randomized, Double-Blind, Placebo-Controlled Trial. Alimentary Phamacology and Therapeutics. November 2010.

Henke DC, Jonas BL, Gabriel D. Activated Factor VII Therapy for Diffuse Alveolar Hemorrhage. US Respiratory Disease. Volume 5, Issue 2. pages 69-77. June 2010.

Henke DC. Bench to Bedside for Curcuma longa L in Cystic Fibrosis-Curcumin’s Controversial Role as Therapy. US Respiratory Disease. Volume 4. Issue 2. pages 76-78. January 2009.

Olajide O, Henke DC, Gabriel DA. Hemorrhagic complications in bone marrow transplant: possible roles of recombinant activated coagulation factor VII, Transfusion Alternatives in Transfusion Medicine, Volume 8 issue s1, page 27-34; December 2006.

Klemmer PJ, Chalermskulrat W, Reif MS, Hogan SL, Henke DC, Falk RJ. Plasmapheresis Therapy for Diffuse Alveolar Hemorrhage in Patients with Small Vessel Vasculitis, American Journal of Kidney Diseases, 42(6): 1149-1153, 2003.

Schwab U, Gilligan P, Jaynes J, Henke D. In Vitro Activities of Designed Antimicrobial Peptides against Multidrug-Resistant Cystic Fibrosis Pathogens. Antimicrobial Agents and Chemotherapy. 43(6): 1435-1440, 1999.

Adler KB and Henke DC. Effects of inflammatory mediators on epithelial function and integrity. In: The Airway Epithelium. Physiology, pathophysiology, and pharmacology (Lung Biology in Health and Disease, Vol. 56). S.G. Farmer and D.W.P. Hay, editors. Marcel Dekker, Inc., New York, 1991.

Van Scott MR, Cheng PW, Henke DC, and Yankaskas JR. Cell culture of airway epithelia. In: The Airway Epithelium. Physiology, pathophysiology, and pharmacology (Lung Biology in Health and Disease, Vol, 55). S.G. Farmer and D.W.P. Hay, editors. Marcel Dekker, Inc., New York. 135-167, 1991.

Van Scott RM, McIntire MR, and Henke DC. 3H-Arachidonic acid metabolism in rabbit nonciliated bronchiolar epithelial (clara) cells. A.J. Physiol.: Lung Cellular and Molecular Physiology, 259: L213-L221, 1990.

Review Boards

Chest (1992 – present)

Peer Reviewer

The Open Respiratory Medicine Journal (2010)

Editorial Board Member and Reviewer