Milan Hazucha



Comenius University (1962)
Bratislava, Slovak Republic

McGill University (1974) 
Montreal, Canada

Academic Title:
Research Professor of Medicine

Office: 538 EPA Building 
Phone: 919-966-0770 
Fax: 919-966-9863 

Selected Publications:

  1. Benignus V.A., M.J. Hazucha, M.V. Smith, P.A. Bromberg. Prediction of carboxyhemoglobin formation due to      transient exposure to carbon monoxide. J. Appl. Physiol. 76:1739-1745, 1994. 
  2. Hazucha, M.J., L.J. Folinsbee, E. Seal, P.A. Bromberg. Lung function response of healthy females following sequential exposures to NO2 and O3. Am. J. Resp. Crit. Care Med. 150:642-647, 1994. 
  3. Shy, C.M., D. Degnan, D.L. Fox, S. Mukerjee, M.J. Hazucha. Respiratory effects of waste incinerators: An air quality and epidemiological study of six communities. Env. Health Persp. 103:714-724, 1995. 
  4. Hazucha, M.J., M. Madden, G. Pape. Effects of cyclooxygenase inhibition on ozone-induced respiratory inflammation and lung function changes. Eur. J. Appl. Physiol. 73:17-27, 1996. 
  5. Passannante, A.N., M.J. Hazucha, P.A. Bromberg. Nociceptive mechanisms modulate ozone-induced human lung function decrements. J. Appl. Physiol. 85(5):1863-1870, 1998. 
  6. Peden, D.B., K. Tucker, P. Murphy, L. Newlin-Clapp, B. Boehlecke, M.J. Hazucha. Eosinophil influx to the nasal airway after local, low-level LPS challenge in humans. J. Allergy Clin. Immunol. 104:388-394, 1999. 
  7. Folinsbee, L.J., M.J. Hazucha. Time course of response to ozone exposure in healthy adult females. Inhal. Toxicol. 12:101-117, 2000. 
  8. Kizakevich, P., M. McCartney, M.J. Hazucha. Noninvasive Ambulatory Assessment of Cardiac Function in Healthy Males Exposed to Carbon Monoxide during Upper and Lower Body Exercise. Eur J Appl Physiol 83:7-16, 2000. 
  9. Hu, S-W., M.J. Hazucha, C. M. Shy. Waste Incineration and Pulmonary Function: An Epidemiological Study of Six Communities. JAWMA, 51:1185-1194, 2001. 
  10. Zariwala, M., P.G. Noone, A. Sannuti, S. Minnix, Z. Zhou, M. W. Leigh, M. Hazucha. Germline Mutations in an Intermediate Chain Dynein Cause Primary Ciliary Dyskinesia. Am. J. Respir. Cell Mol. Biol. 25: 577-583, 2001. 
  11. Hazucha M.J., V. Rhodes, B.A. Boehlecke, K. Southwic, D. Degnan, C.M. Shy. Characterization of spirometric function in residents of three comparison communities and of three communities located near waste incinerators in North Carolina. Arch. Environ. Health. 57(2):103-112, 2002. 
  12. Calderon-Garciduenas L, Mora-Tiscareno A, Fordham L.A, Valencia-Salazar G, Chung CJ, Rodriguez-Alcaraz A, Paredes R, Variakojis D, Villarreal-Calderon A, Flores-Camacho L, Antunez-Solis A, Henriquez-Roldan C and Hazucha M. J. Respiratory damage in children exposed to urban pollution. Pediatr Pulmonol 36: 148-161, 2003. 
  13. Hazucha M.J., L.J. Folinsbee, P.A. Bromberg. Distribution and reproducibility of spirometric response to ozone by gender and age. J. Appl. Physiol., 95:1917-1925, 2003. 
  14. Boehlecke, B., Alexis N.E., Hazucha M. Low dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmatics. J. Allergy Clin Immunol 112/6:1241-1243, 2003. 
  15. Noone, P., J. Carson, M.J. Hazucha, M. Leigh. Primary ciliary dyskinesia: Diagnostic and phenotypic features. Am. J. Respir. Crit. Care Med.169:459-467, 2004. 
  16. Kongerud, J, M.C. Madden, M. Hazucha, D. Peden. Nasal Responses in Asthmatic and Nonasthmatic Subjects Following Exposure to Diesel Exhaust Particles. Inhal Tox 18:589-594, 2006. 
  17. Calderon-Garciduenas L, Mora-Tiscareno A, Fordham L.A, Chung C.J, Valencia-Salazar G, Flores-Gómez S, Solt A.C, Gomez-del Campo A, Jardón-Torres R, Henríquez-Roldán C, Hazucha M.J., Reed W. Lung radiology and pulmonary function of children chronically exposed to air pollution. Envr Health Persp 114:1432-1437, 2006.
  18. Zariwala M.A., M.W. Leigh, F. Ceppa, M.P. Kennedy, P.G. Noone, J.L. Carson, M.J. Hazucha. Mutations of DNAI1 in Primary Ciliary Dyskinesia: Evidence of Founder Effect in a Common Mutation. Am. J. Respir. Crit Care Med. 174:858-866, 2006. 
  19. Sawyer K, J.S. Brown, M.J. Hazucha, and W.D. Bennett. The Effect of Exercise on Nasal Uptake of Ozone in Healthy Human Adults. J Appl Physiol, 102:1380-1386, 2007. 
  20. Lay J.C., N.E. Alexis , S.R. Kleeberger, R.A.S. Roubey, B. D. Harris, P. A. Bromberg, M.J. Hazucha, R.B. Devlin, and D.B Peden. Ozone Enhances Markers of Innate Immunity and Antigen Presentation on Airway Monocytes in Healthy Individuals. J Allergy Clin Immunol, 120/3:719-722, 2007. 
  21. Hazucha, M.J. and A.S. Lefohn. Nonlinearity in human health responses to ozone: experimental laboratory considerations. Atmos Environ 41/22:4559-4570, 2007. 
  22. Calderón-Garcidueñas L, R. Vincent, A. Mora-Tiscareño, M. Franco-Lira, C. Henríquez-Roldán, G. Barragán-Mejía, L. Garrido-García, L. Camacho-Reyes, G. Valencia-Salazar, R. Paredes, L. Romero, H. Osnaya, R. Villarreal-Calderón, R. Torres-Jardón, M. J. Hazucha, and W. Reed. Elevated plasma endothelin-1 and pulmonary arterial pressure in children exposed to air pollution. Envir Health Persp. 115/8:1248-1253, 2007. 
  23. Bennett W.D., M. J. Hazucha, L. J. Folinsbee, P. A. Bromberg, G. E. Kissling, and S. J. London. Acute Pulmonary Function Response to Ozone in Young Adults as a Function of Body Mass Index. Inhal Toxicol 19:1147-1154, 2007. 
  24. Hazucha, M.J.. Controlled Human Exposure Studies of Ozone and Related Photochemical Oxidants. In:”Air Quality Criteria for Ozone and Other Photochemical Oxidants” USEPA/NCEA Publ. EPA-600//R-05/004b,bF & cF, Vol.II Chap. 6 (sec.6.2.5, 6.5, 6.11) and Vol.III Chap. AX6 (sec.AX6.2.5, AX6.5, AX6.11), 2007. 
  25. Alexis NE, Lay JC, Haczku A, Gong H, Linn W, Hazucha MJ, Harris B, Tal-Singer R, Peden DB. Fluticasone Propionate Protects against Ozone-Induced Airway Inflammation and Modified Immune Cell Activation Markers in Healthy Volunteers. Environ Health Perspect. 116(6):799-805, 2008. 
  26. Zhou H., X. Wang, L. Brighton, M. Hazucha, I. Jaspers, and J.L. Carson. Increased Nasal Epithelial Ciliary Beat Frequency Associated With Lifestyle Tobacco Smoke Exposure. Inhal Toxicol. 21/6: xxxx, 2009. 
  27. Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, Herbst M, Bassett M, Montilla T, Hazucha MJ, Bromberg PA, Devlin RB... Concentrated Ambient Ultrafine Particle Exposure Induces Cardiac Changes in Young Healthy Volunteers. Am J Respir Crit Care 179:xxx, 2009.

Selected Chapters/Reviews: 

  1. Hazucha, M.J. Health effects due to interaction of nitrogen oxides and ozone. In: Health effects of ozone and nitrogen oxides in an integrated assessment of air pollution. Institute for Environment and Health, Publ., Leicester, UK, pp.42-52, 1997.
  2. Hazucha, M.J. and D. Pankow. Toxicokinetics and metabolism. In: Environmental Health Criteria 213, Carbon Monoxide, Chen, Q. and J. Raub, eds., WHO/IPCS Task Group, WHO Geneva, Chap. 6, pp. 134-161, 1999.
  3. Hazucha, M.J. M. Mathieu-Nolf, Q. Chen. Effects on humans. In: Environmental Health Criteria 213, Carbon Monoxide, Chen, Q. and J. Raub, eds., WHO/IPCS Task Group, WHO Geneva, Chap. 8, pp. 250-334, 1999.
  4. Hazucha, M.J., S.Thom. Pharmacokinetics and mechanisms of action. In: Air Quality Criteria For Carbon Monoxide, J. Raub et al., eds., USEPA/NCEA, EPA/600/P-99/001, Chap. 5, pp. 5-1 to 5-30, 2000.
  5. Hazucha, M.J.. Effect of carbon monoxide on work and exercise capacity in humans. In: Carbon Monoxide Toxicity, D. Penney, ed., CRC Press, Chap. 5, pp. 101-134, 2000.
  6. Cascio W.E., Hazucha M.J, Bromberg P.A., Devlin R.B. Cardiovascular Effects of Air Pollutants. In: “Netter’s Cardiology”. 1st ed., Runge, M and Ohman, M. eds., Icon Learning Systems, Teterboro, NJ, Chapter 65, pp.627-631, 2004.
  7. Hazucha, M.J. and A.S. Lefohn. Nonlinearity in human health responses to ozone: experimental laboratory considerations. Atmos Environ 41/22:4559-4570, 2007.
  8. Hazucha, M.J. Cascio W.E., R.B, Stone S. and Wildermann, E. PM and Your Patients' Health. Web training course for health professionals. US EPA Air Pollution Training Institute. 2009.
  9. Cascio W.E., Hazucha M. J, Stone S., Devlin R.B.. Cardiovascular Effects of Air Pollutants. In: “Netter’s Cardiology”. 2nd ed., Runge, M and Ohman, M. eds., Icon Learning Systems, Teterboro, NJ, Chapter 75, 2009 (in press).