Scott H Randell, MD

Degrees:Scott Randell

BA: 
(1979) State University of NY College @ New Paltz

PhD: 
(1985): John Hopkins University 
Baltimore, MD

Academic Title: 

Research Associate Professor of Medicine 

Office: 4011-A Thurston Bowles Building 
Phone: 919-966-8093 
Lab: 919-843-9948 
Email: randell@med.unc.edu

Research Interests: 

Airway epithelial biology - stem cells, host defense and response to injury

Recent Publications:

Chalermskulrat W, Neuringer IP, Brickey WJ, Felix NJ, Randell SH, Ting JP, Aris RM. Hierarchical contributions of allorecognition pathways in chronic lung rejection. Am J Respir Crit Care Med. 2003 Apr 1;167(7):999-1007. 

Chalermskulrat W, Neuringer IP, Schmitz JL, Catellier DJ, Gurka MJ, Randell SH, Aris RM. Human leukocyte antigen mismatches predispose to the severity of bronchiolitis obliterans syndrome after lung transplantation. Chest. 2003 Jun;123(6):1825-31. 

Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismuller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL.
Activation of toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol. 2003 Dec 15;171(12):6820-6. 

KG Schoch, A Lori, KA Burns, T Eldred, JC Olsen and SH Randell. A Subset of Mouse Tracheal Epithelial Basal Cells Generates Large Colonies in Vitro. Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L631-42. 

MN Becker, MS Sauer, M Muhlebach, AJ Hirsh, Qi Wu, MW Verghese and SH Randell. Cytokine Secretion by Cystic Fibrosis Airway Epithelial Cells. Am J Respir Crit Care Med. 2004 Mar 1;169(5):645-53. 

Perez-Vilar J, Randell SH, Boucher RC. C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology. 2004 Apr;14(4):325-37. 

Bruen KJ, Campbell CA, Schooler WG, deSerres S, Cairns BA, Hultman CS, Meyer AA, Randell SH. Real-time monitoring of keratin 5 expression during burn re-epithelialization. J Surg Res. 2004 Jul;120(1):12-20. 

Chalermskulrat W, Neuringer IP, Park RC, Brickey WJ, Braeckman RA, Randell SH, Aris RM. PX3.102, a novel chinese herb extract, diminishes chronic airway allograft rejection. Transplantation. 2004 Jul 15;78(1):158-61. 

Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol. 2004 Jul;287(1):C171-81. 

Neuringer IP, Randell SH. Stem cells and repair of lung injuries. Respir Res. 2004 Jul 20;5(1):6. 

Davidson DJ, Gray MA, Kilanowski FM, Tarran R, Randell SH, Sheppard DN, Argent BE, Dorin JR. Murine epithelial cells: isolation and culture. J Cyst Fibros. 2004 Aug; 3 Suppl 2:59-62. Review. 

Holmen JM, Karlsson NG, Abdullah LH, Randell SH, Sheehan JK, Hansson GC, Davis CW. Mucins and their O-Glycans from human bronchial epithelial cell cultures. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L824-34. Epub 2004 Jun 11. 

Fragoso MA, Fernandez V, Forteza R, Randell SH, Salathe M, Conner GE. Transcellular Thiocyanate Transport by Human Airway Epithelia. J Physiol. 2004 Sep 2 [Epub ahead of print] 

Nissim-Rafinia M, Aviram M, Randell SH, Shushi L, Ozeri E, Chiba-Falek O, Eidelman O, Pollard HB, Yankaskas JR, Kerem B. Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation. EMBO Rep. 2004 Oct 08 [Epub ahead of print] 

Harris JF, Fischer MJ, Hotchkiss JR, Monia BP, Randell SH, Harkema JR, Tesfaigzi Y. Bcl-2 Sustains Increased Mucous and Epithelial Cell Numbers in Metaplastic Airway Epithelium. Am J Respir Crit Care Med. 2005 Apr 1;171(7):764-72. Epub 2004 Dec 23; 

Wu Q, Lu Z, Verghese MW, Randell SH. Airway epithelial cell tolerance to Pseudomonas aeruginosa. Respir Res. 2005 Apr 1;6(1);26. 

Das S. Palmer OP, Leight WD, Surowitz JB, Pickles RJ, Randell SH, Buchman CA. Cytokine ampilification byrespiratory syncytial virus infection in human nasal epithelial cells. Laryngoscope. 2005 May;115(5):764-8. 

Slebos RJ, Livanos E, Yim HW, Randell SH, Parsons AM, Detterbeck FC, Rivera MP, Taylor JA. Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients. Cancer Genet Cytogenet. 2005 Jun;159(2);137-42. 

Matsui H. Verghese MW, Kesimer M, Schwab UE, Randell SH, Sheehan JK, Grubb BR, Boucher RC. Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces. J Immunol. 2005 Jul 15;175(2);1090-9. 

Neuringer IP, Sloan J, Budd S, Chalermskulrat W, Park RC, Stonebraker JR, O’Neal WK, Aris RM, Randell SH. Calcineurin inhibitor effects on growth and phenotype of human airway epithelial cells in vitro. Am J Transplant. 2005 Nov;5(11):2660-70. 

Koukoulis G, Caldwell R, Inokawa H, Button B, Sevala M, Lyles JD, Takashima S, Blackwell J, Randell SH, Egan TM. Trends in lung pH and PO2 after circulatory arrest: implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injury. J Heart Lung Transplant. 2005 Dec;24(12):2218-25. Epub 2005 Nov 17. 

Grubb BR, Gabriel SE, Mengos A, Gentzsch M, Randell SH, Van Heeckeren AM, Knowles MR, Drumm ML, Riordan JR, Boucher RC. SERCA Pump Inhibitors Do Not Correct Biosynthetic Arrest of ΔF508CFTR in Cystic Fibrosis. Am J Respir Cell Mol Biol. 2006 Mar;34(3):355-63. 

Gomperts BN, Belperio JA, Rao PN, Randell SH, Fishbein MC, Burdick MD, Strieter RM. Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol. 2006 Feb 1;176(3):1916-27. 

Randell SH, Boucher RC. Effective Mucus Clearance is Essential for Respiratory Health. Am J Respir Cell Mol Biol. 2006 Jul;35(1):20-8. Epub 2006 Mar 9. 

Neuringer IP, Randell SH. Lung stem cell update: promise and controversy. Monaldi Arch Chest Dis. 2006 Mar;65(1):47-51. Review. 

Randell SH. Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Oct;3(8):718-25. 

Even-Tzur N, Elad D, Zaretsky U, Randell SH, Haklai R, Wolf M. Custom Designed Wells and Flow Chamber for Exposing Air-Liquid Interface Cultures to Wall Shear Stress. Ann Biomed Eng. 2006 Dec;34(12):1890-5. 
 
Dejima K, Randell SH, Stutts MJ, Senior BA, Boucher RC. Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis. Arch Otolaryngol Head Neck Surg. 2006 Dec;132(12):1352-62. 

Yim HW, Slebos RJ, Randell SH, Umbach DM, Parsons AM, Rivera MP, Detterbeck FC, Taylor JA. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. Cancer Lett. . 2007 Feb 8;246(1-2):24-33. 

Rawlins EL, Ostrowski LE, Randell SH, Hogan BL. Lung development and repair: Contribution of the ciliated lineage. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):410-7. 

Conner GE, Wijkstrom-Frei C, Randell SH, Fernandez VE, Salathe M. The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett. Jan 23;581(2):271-8. Epub 2006 Dec 19. 

Livraghi A, Randell SH. Cystic fibrosis and other respiratory diseases of impaired mucus clearance. Toxicologic Pathology. 2007;35(1):116-29. 

Saavedra MT, Patterson AD, West J, Randell SH, Riches DW, Malcolm KC, Cool CD, Nick JA, Dinarello CA. Abrogation of anti-inflammatory transcription factor LKLF in neutrophil dominated airways. Am J Respir Cell Mol Biol. 2008 Jun;38(6):679-88. Epub 2008 Jan 24. 

Schwalm K, Stevens JF, Jiang Z, Schuyler MR, Schrader R, Randell SH, Green FH, Tesfaigzi Y. Expression of the proapoptotic protein Bax is reduced in bronchial mucous cells of asthmatic subjects. Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1102-9. Epub 2008 Apr 4. 

Ahmad S, Ahmad A, Dremina ES, Sharov VS, Guo X, Schneider BK, Jones TN, Loader JE, Tatreau J, Perraud A, Schöneich C, Randell SH, White CW. Bcl-2 suppresses SERCA2 expression in cystic fibrosis airway epithelial cells: Role in oxidant-mediated cell death. (in revision) 

Luo X, Okubo T, Randell SH, Hogan BI. Culture of endodermal stem/progenitor cells of the mouse tongue. (in press, In Vitro Cellular & Developmental Biology-Animal). 

Polosukhin VV, Lawson WE, Kwon M, Milstone AP, Ocak S, Massion PP, Kononov AV, Randell SH, Blackwell TS. Bronchial epithelial remodeling in COPD impairs mucosal immunity through reduced pIgR expression. 

Fulcher ML, Gabriel SE, Olsen JC, Livanos E, Tatreau JR, Saavedra MT, Salmon P, Randell SH. Novel Human Bronchial Epithelial Cell Lines For Cystic Fibrosis Research. (in revision, AJP).