Publications and Patents

 

Original research:

  1. Tian X, Nguyen M, Foote HP, Caster JM, Roche KC, Peter C, Wu P, Jayaraman L, Garmey E, Tepper JE, Eliasof S, Wang AZ. CRLX101, a nanoparticle-drug conjugate containing camptothecin improves rectal cancer chemoradiotherapy in mice through inhibition of both DNA repair and HIF-1α. Cancer Research, 2017 Jan 1;77(1):112-122
  2. Huang H, Shi H, Liu J, Min Y, Wang Y, Wang AZ, Wang J, Liu Y. Co-delivery of All-trans-retinoic Acid Enhances Anti-Metastasis Effect of Albumin-Bound Paclitaxel Nanoparticles. ChemComm, 2016 Dec 20;53(1):212-215.
  3. Tian J, Rodgers Z, Min Y, Wan X, Qiu H, Mi Y, Tian X, Wagner K, Caster JM, Qi Y, Roche K, Zhang T, Cheng J, Wang AZ. Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer. Nanomedicine NBM, 2016 Nov 21. pii: S1549-9634(16)30199-X.
  4. Min Y, Tian S, Eblan M, Roche KC, McKinnon KP, Zhang L, Zhang T, Tepper J, Vincent BG, Serody JS, Wang AZ. Antigen capturing nanoparticles improve the abscopal effect and cancer immunotherapy. Nature Nanotechnology, under revision.
  5. Lian J, Shao Y, Potter LD, Chen RC, Holmes JA, Pryser EA, Shen J, Shen D, Wang AZ. Prostate Deformation from Inflatable Rectal Probe Cover and Dosimetric Effects in Prostate Seed Implant Brachytherapy. Medical Physics, 2016 Dec;43(12):6569.
  6. Diao K, Lobos EA, Pearlstein KA, Yirmibesoglu E, Basak R, Hendrix LH, Barbosa B, Miller S, Goldin GH, Wang AZ, Chen RC. Patient-reported quality of life during definitive and post-prostatectomy image-guided radiation therapy for prostate cancer. Practical Radiation Oncology, in press.
  7. Rose TL, Deal AM, Ladoire S, Créhange G, Galsky MD, Rosenberg JE, Bellmunt J, Wimalasingham A, Wong YN, Harshman LC, Chowdhury S, Niegisch G, Liontos M, Yu EY, Pal SK, Chen RC, Wang AZ, Nielsen ME, Smith AB, Milowsky MI. Patterns of Bladder Preservation Therapy Utilization for Muscle-Invasive Bladder Cancer. Bladder Cancer. 2016 Oct 27;2(4):405-413.
  8. Wang GD, Nguyen HT, Chen H, Cox PB, Wang L, Nagata K, Hao Z, Wang A, Li Z, Xie J. X-Ray Induced Photodynamic Therapy: A Combination of Radiotherapy and Photodynamic Therapy. Theranostics. 2016 Oct 1;6(13):2295-2305.
  9. Wang C, Sun W, Wright G, Wang AZ, Gu Z. Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody. Advanced Materials, 2016 Aug 25.
  10. Tian X, Warner SB, Wagner KT, Caster JM, Zhang T, Ohana P, Gabizon AA, Wang AZ. Preclinical evaluation of Promitil®, a radiation-responsive liposomal formulation of mitomycin C prodrug, in chemoradiotherapy. Int J Radiat Oncol Biol Phys., 2016 Nov 1;96(3):547-55. PMID: 27681751.
  11. Yao H, Qiu H, Shao Z, Wang G, Wang J, Yao Y, Xin Y, Zhou M, Wang AZ, Zhang L. Nanoparticle formulation of small DNA molecules, Dbait, improves the sensitivity of hormone-independent prostate cancer to radiotherapy. Nanomedicine. 2016 Jul 4. pii: S1549-9634(16)30083-1.
  12. Gao Y, Shao Y, Lian J, Wang AZ, Chen RC, Shen D. Accurate Segmentation of CT Male Pelvic Organs via Regression-based Deformable Models and Multi-task Random Forests. IEEE Transactions on Medical Imaging, 2016 Jun;35(6):1532-43. Epub 2016 Jan 18. PMID: 26800531
  13. Au KM, Satterlee A, Min Y, Tian X, Kim YS, Caster JM, Zhang L, Zhang T, Huang L, Wang AZ. Folate-targeted pH-responsive calcium zolendronate nanoscale metal-organic frameworks:turning a bone antiresorptive agent into an anticancer therapeutic. Biomaterials, 2016 Mar;82:178-93. PMID: 26763733. 
  14. Au KM, Hyder SN, Wagner K, Shi C, Kim YS, Caster JM, Tian X, Min Y, Wang AZ. Direct observation of early-stage high-dose radiotherapy-induced vascular injury via basement membrane-targeting nanoparticles. Small. 2015 Dec;11(48):6404-10. PMID: 26577747 
  15. Tian X, Lara H, Wagner KT, Saripalli S, Hyder SN, Foote M, Sethi M, Wang E, Caster JM, Zhang L, Wang AZ. Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. Nanoscale, 2015, Dec 21;7(47):20211-9. PMID: 26575637.
  16. Au KM, Min Y, Tian X, Zhang L, Perello V, Caster JM, Wang AZ. Improving cancer chemoradiotherapy treatment by dual controlled release of wortmannin and docetaxel in polymeric nanoparticles. ACS Nano, 2015 Sep 22;9(9):8976-96. PMID: 26267360
  17. Zhu X, Driewer J, Li S, Lei Y, Verma V, Cullip T, Zhang M, Zhang Q, Wang AZ, Chang S, Zhou SM, Enke C. Fabricating Cerrobend Grids with 3D Printing for Spatially Modulated Radiation Therapy: A Feasibility Study. Medical Physics, 2015 Nov;42(11):6269. doi: 10.1118/1.4932223.
  18. Rose TL, Deal AM, Basch E, Godley PA, Rathmell WK, Kim WY, Whang YE, Dunn MW, Wang A, Chen RC, Nielsen ME, Pruthi RS, Wallen EM, Woods ME, Smith AB, Milowsky MI. Neoadjuvant chemotherapy administration and time to cystectomy for muscle-invasive bladder cancer: An evaluation of transitions between academic and community settings. Urol Oncol. 2015 Sep;33(9):386.e1-6. doi: 10.1016/j.urolonc.2015.05.028. 
  19. Wang EC, Min Y, Palm RC, Fiordalisi J, Wagner KT, Hyder N, Tian X, Moore D, Caster J, Cox AD, Wang AZ. Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors. Biomaterials. 2015, May;51:208-15. doi: 10.101
  20. Wang J, Zheng J, Tang T, Zhu F, Yao Y, Xu J, Wang AZ, Zhang L. A Randomized Pilot Trial Comparing Position Emission Tomography (PET)-Guided Dose Escalation Radiotherapy to Conventional Radiotherapy in Chemoradiotherapy Treatment of Locally Advanced Nasopharyngeal Carcinoma. PlosOne, 2015 Apr 27;10(4):e0124018
  21. Caster JM, Sethi M, Kowalczyk S, Wang E, Tian X, Hyder SN, Wagner KT, Zhang YA, Kapadia C, Au KM and Wang AZ. Nanoparticle delivery of chemosensitizers to improve chemotherapy efficacy without incurring additional toxicity. Nanoscale, 2015, 7, 2805-2811
  22. Byrne JD, Jajja MR, O’Neill AT, Bickford LR, Keeler AW, Hyder N, Wagner K, Deal A, Little RE, Moffitt RE, Stack C, Nelson M, Brooks C, Lee W, Luft C, Napier ME, Darr D, Anders RC, Stack R, Tepper JE, Wang AZ, Zamboni WC, Yeh JJ, DeSimone JM. Local Iontophoretic Administration of Cytotoxic Therapies to Solid Tumors. Science Translational Medicine. 2015 Feb 4;7(273):273ra14.
  23. Sethi M, Sukumar R, Karve S, Werner ME, Wang EC, Moore DT, Kowalczyk SR, Zhang L, Wang AZ. Effect of Drug Release Kinetics on Nanoparticle Therapeutic Efficacy and Toxicity. Nanoscale, 2014, 6 (4), 2321 – 2327
  24. Della Rocca J, Werner ME, Kramer SA, Huxford-Phillips RC, Sukumar R, Cummings ND, Vivero-Escoto JL, Wang AZ*, Lin W*. Polysilsesquioxane Nanoparticles for Triggered Release of Cisplatin and Effective Cancer Chemoradiotherapy. Nanomedicine: Nanotechnology Biology and Medicine, 2014 Jul 17. pii: S1549-9634(14)00391-8. . *Corresponding authors. 2014, 4 pages.
  25. Chen RC, Hendrix LH, Carpenter WR, Bainbridge J, Wang AZ, Nielsen ME, Godley PA. Receipt of guideline-concordant treatment in elderly prostate cancer patients. Int J Radiat Oncol Biol Phys., 2014 Feb: 88 (2):332-338.
  26. Xu Z, Chen RC, Wang AZ, Kress A, Foskey M, Qin A, Cullip T, Tracton G, Chang S, Tepper J, Yan D, and Chaney E. Comparison of User-Directed and Automatic Mapping of the Planned Isocenter to Treatment Space for Prostate IGRT," International Journal of Biomedical Imaging, vol. 2013, Article ID 892152, 2013.
  27. Chu KS, Schorzman AN, Finniss MC, Bowerman CJ, Peng L, Luft JC, Madden AJ, Wang AZ, Zamboni WC, Desimone JM. Nanoparticle drug loading as a design parameter to improve docetaxel pharmacokinetics and efficacy. Biomaterials, 2013 Nov;34(33):8424-9.
  28. Wang EC, Sinnott R, Werner ME, Sethi M, Whitehurst AW, Wang AZ. Differential Cell Responses to Nanoparticle Docetaxel and Small Molecule Docetaxel at a Sub-Therapeutic Dose Range. Nanomedicine: Nanotechnology Biology and Medicine. 2013. Aug 3. pii: S1549-9634(13)00353-5.
  29. Gallagher SASmith ABMatthews JEPotter CWWoods MERaynor MWallen EMKimryn Rathmell WWhang YEKim WYGodley PAChen RCWang A, You CBarocas DAPruthi RSNielsen MEMilowsky MI. Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database-UNC GOLD. Urol Oncol. 2013 Feb 19 pii:S1078-1439(12)
  30. Werner ME, Cummings ND, Sukumar R, Sethi M, Wang EC, Moore DT, Dees EC, Wang AZ. Preclinical evaluation of Genexol-PM, a nanoparticle formulation of paclitaxel, as a novel radiosensitizer for the treatment of non-small cell lung cancer. Int J Radiat Oncol Biol Phys,  2013 Jul 1;86(3):463-8.
  31. Stokes WA, Hendrix LH, Royce TJ, Allen IM, Godley PA, Wang AZ, Chen RC. Racial differences in time from prostate cancer diagnosis to treatment initiation, a population-based study. Cancer, 2013 Jul 1;119(13):2486-93.
  32. Karve S, Werner ME, Sukumar R, Cummings ND, Copp JA, Wang EC, Li C, Chen RC, Pacold ME, Wang AZ. Revival of the Abandoned Therapeutic Wortmannin by Nanoparticle Drug Delivery. Proceedings of the National of Academy of Sciences, 2012 May 22;109(21):8230-5.
  33. Chen RC, Rosenman JG, Hoffman LG, Chiu WK, Wang AZ, Pruthi RS, Wallen EM, Crane JM, Kim WY, Rathmell WK, Godley PA, Whang YE. Phase I study of concurrent weekly docetaxel, high-dose intensity-modulated radiation therapy (IMRT) and androgen-deprivation therapy (ADT) for high-risk prostate cancer. British Journal of Urology.  2012 Sep 27.
  34. Werner ME, Foote MB, Wang AZ. Chemoradiotherapy of Human Tumors: Novel Approaches from Nanomedicine. Current Pharmaceutical Design, 2012;18(19):2830-7.
  35. Di Pasqua AJ, Huckle JE, Kim JK, Chung Y, Wang AZ, Jay M, Lu X. Preparation of Neutron Activatable Holmium Nanoparticles for the Treatment of Ovarian Cancer Metastases. Small, Apr 10;8(7):997-1000.
  36. Holmes JA, Wang ZA, Hoffman KE, Hendrix LH, Rosenman JG, Carpenter WR, Godley PA, Chen RC. Is Primary Prostate Cancer Treatment Influenced by Likelihood of Extraprostatic Disease? A Patterns of Care Study Using the Surveillance Epidemiology and End Results Database. Int J Radiat Oncol Biol Phys, 2012 Jan 31.
  37. Werner ME, Karve S, Sukumar R, Cummings ND, Copp JA, Chen RC, Zhang T, Wang AZ. Folate targeted nanoparticle delivery of chemo- and radio-therapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials, 2011 Nov;32(33):8548-54. 
  38. Werner ME, Copp JA, Karve S, Cummings ND, Sukumar R, Napier M, Chen RC, Cox AD, Wang AZ. Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy. ACS Nano, 2011 Nov 22;5(11):8990-8.
  39. Karve S, Werner ME, Cummings ND, Sukumar R, Wang EC, Zhang YA, Wang AZ. Formulation of diblock polymeric nanoparticles through nanoprecipitation technique. J Vis Exp. 2011 Sep 20;(55)
  40.  Merkel TJ, Jones SW, Herlihy KP, Kersey FR, Shields AR, Napier M, Wang AZ, Bear JE, DeSimone JM. Using Mechano-biological Mimicry to Extend Circulation Times of Red Blood Cell Replicas. Proceedings of the National Academy of Sciences, 2011 Jan 11;108(2):586-91. PMCID: PMC3021010
  41. Wang AZ, Yuet K, Zhang LF, Gu FX, Huynh-Le M, Radovic-Moreno AF, Kantoff PW, Bander NH, Langer R, Farokhzad OC. ChemRad Nanoparticles: A Novel Multifunctional Nanoparticle Platform for Targeted Delivery of Concurrent Chemoradiation. Nanomedicine, 2010 Apr; 5(3): 361-8. PMCID: PMC2901911
  42. Wang AZ, Bagalkot V, Vasilliou C, Gu F, Alexis F, Zhang LF, Shaikh M, Yuet K, Cima M, Langer R, Kantoff PW, Bander NH, Jon S, Farokhzad OC. Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy. ChemMedChem. 2008, 3(9):1311-5.
  43. Wang AZ, Gu F, Zhang LF, Chan JM, Radovic-Moreno A, Shaikh MR, Farokhzad OC. Biofunctionalized Targeted Nanoparticles for Therapeutic Applications. Expert Opinions on Biological Therapy, 2008; 8(8):1063-70.  
  44. Gu F, Zhang LF, Teply B, Mann N, Wang A, Radovic-Moreno AF, Langer R, Farokhzad OC. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block co-polymers. Proceedings of the National of Academy of Sciences, 2008, 105(7): 2586-91.
  45. Tam WF, Gu TL, Chen J, Lee BH, Bullinger L, Fröhling S, Wang A, Monti S, Golub TR, Gilliland DG. Oncogenic tyrosine kinases upregulate Id1 in leukemic cells. Blood, 2008, 112(5):1981-92.
  46. Zhang L, Chan J, Gu F, Rhee JW, Wang AZ, Radovic-Moreno A, Alexis F, Langer R, Farokhzad OC. Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform. ACS Nano, 2008, 2(8); 1696-1702.
  47. Alexis F, Basto P, Levy-Nissenbaum E, Radovic-Moreno AF, Zhang L, Pridgen E, Wang AZ, Marein SL, Westerhof K, Molnar LK, Farokhzad OC. HER-2-Targeted Nanoparticle-Affibody Bioconjugates for Cancer Therapy. ChemMedChem, 2008, 3(12): 1839-1843

 

o             Other peer-reviewed articles:

  1. Cai K, Wang AZ, Yin L, Cheng J. Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties. Journal of Controlled Release, 2017 Jan 3. pii: S0168-3659(16)30527-2.
  2. Mi Y, Shao J, Vang J, Kaidar-Person O, Wang AZ. Application of nanotechnology to cancer radiotherapy. Cancer Nanotechnology, 2016 7:11 DOI: 10.1186/s12645-016-0024-7
  3. Shao Z, Wang AZ, George DJ, Zhang T. Novel Immunotherapy Approaches for Metastatic Urothelial and Renal Cell Carcinoma. Asian Journal of Urology, 2016 3, 268-277.
  4. Qiu H, Min Y, Rodger Z, Zhang L, Wang AZ. Nanomedicine approaches to improve cancer immunotherapy. WIRES Nanomedicine and Nanobiotechnology. In press
  5. Caster JM, Patel AN, Zhang T, Wang AZ. Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials. WIRES Nanomedicine and Nanobiotechnology. In press
  6. Min Y, Caster J, Eblan M, Wang AZ. Clinical Translation of Nanomedicine, Chemical Reviews, Jun 19, 2015 [Epub ahead of print] PMID: 26088284
  7. Wang AZ, Tepper JE. Nanotechnology in Radiation Oncology. J Clin Oncol. 2014 Sep 10;32(26):2879-2885. 
  8. Wang AZ, Farokhzad OC. Current Progress of Aptamer-Based Molecular Imaging. J Nucl Med. 2014 Mar;55(3):353-6. doi: 10.2967
  9. Chapman S, Dobrovolskaia M, Farahani K, Goodwin A, Joshi A, Lee H, Meade T, Pomper M, Ptak K, Rao J, Singh R, Sridhar S, Stern S, Wang AZ, Weaver JB, Woloschak G, Yang L. Nanoparticles for cancer imaging: the good, the bad and the promise. Nanotoday, Volume 8, Issue 5, October 2013, Pages 454–460.
  10. Wang EC, Wang AZ. Nanoparticles and their applications in cell and molecular biology. Integr Biol (Camb). 2014 Jan;6(1):9-26. Review.
  11. Eblan MJ, Wang AZ. Improving chemoradiotherapy with nanoparticle therapeutics. Transl Cancer Res. 2013 Aug 1;2(4):320-329
  12. Liu D, He C, Wang AZ, Lin W. Application of liposomal technologies for delivery of platinum analogs in oncology. Int J Nanomedicine. 2013;8:3309-19.
  13. 13.    Goldberg MS, Hook SS, Wang AZ, Bulte JW, Patri AK, Uckun FM, Cryns VL, Hanes J, Akin D, Hall JB, Gharkholo N, Mumper RJ. Biotargeted nanomedicines for cancer: six tenets before you begin. Nanomedicine (Lond). 2013 Feb;8(2):299-308.
  14. 14.    Miller SM, Wang AZ. Nanomedicine in chemoradiation. Ther Deliv. 2013 Feb;4(2):239-50.
  15. 15.    Wang AZ, Langer R, Farokhzad OC. Nanoparticle Delivery of Cancer Drugs. Annual Reviews of Medicine. 2012;63:185-98.
  16. 16.    McRee AJ, Cowherd S, Wang AZ, Goldberg RM. Chemoradiation Therapy in the Management of Gastrointestinal Malignancies. Future Oncol. 2011 Mar;7(3): 409-26.
  17. 17.    Levy-Nissenbaum E, Radovic-Moreno AF, Wang AZ, Langer R, Farokhzad OC. Nanotechnology and aptamers: applications in drug delivery. Trends Biotechnol. 2008 Aug;26(8):442-9.
  18. 18.   Zhang L, Gu FX, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in Medicine: Therapeutic Applications and Developments. Clinical Pharmacology and Therapeutics, 2007; 83(5):761-9.
  19. 19.    Gu F, Karnik R, Wang A, Alexis F, Levy-Nissenbaum E, Hong S, Langer R, Farokhzad OC. Targeted Nanoparticles for Cancer Therapy.  NanoToday, 2007; Vol. 2, No. 3, pg 14-21.
  • Editorials:
  1. Wang AZ. Personalized drug tablets with 3D printing. Science Translational Medicine, 04 Nov 2015: Vol. 7, Issue 312, pp. 312ec191 DOI: 10.1126/scitranslmed.aad5507
  2. Wang AZ. Precision Cancer medicine: Hype or hope? Science Translational Medicine, 23 Sep 2015: Vol. 7, Issue 306, pp. 306ec164 DOI: 10.1126/scitranslmed.aad3623
  3. Wang AZ. EPR or no EPR? The billion-dollar question. Science Translational Medicine 01 Jul 2015:
    Vol. 7, Issue 294, pp. 294ec112 DOI: 10.1126/scitranslmed.aac8108
  4. Wang AZ. More than just a fruit:Grapefruit-derived nanovectors deliver cancer drugs. Science Translational Medicine. 20 May 2015: Vol. 7, Issue 288, pp. 288ec83 DOI: 10.1126/scitranslmed.aac4995
  5. Tepper JE, Wang AZ. Scoring the Recurrence Score in Rectal Cancer. JNCI, 2014 106 (11): dju295
  6. Wang, AZ. Nanoparticle Formulations of siRNA: The Next Generation of Targeted Therapy for Lymphomas and Leukemias? EBioMedicine, 1 (2014) 101–102
  7. Wang, AZ. Giving failed drugs a fresh chance: a new direction for nanoparticle drug delivery. Expert Rev. Med. Devices, 2012 Sep;9(5):445-7.
  8. Wang, AZ. Nanoparticle drug delivery: focusing on the therapeutic cargo. Nanomedicine, 2012 Oct;7(10):1463-5.
  9. Tepper JE, Wang AZ. Improving local control in rectal cancer: radiation sensitizers or radiation dose? Journal of Clinical Oncology, J Clin Oncol. 2010 Apr 1;28(10):1623-4.

 

 

  • Patent applications:
  1. Wang AZ, Tian X, Reid LM. METASTASES ON A DISH: ENGINEERED COLORECTAL CANCER METASTASES USING TISSUE-SPECIFIC BIOMATRIX SCAFFOLDS. US 62/460,056
  2. Kabanov AV, Sokolsky M, Gershon TR, Wang AZ, Min Y, Wan X, Lang P. COMPOSITIONS AND METHODS USING POLY(OXAZOLINE) MICELLES FOR DELIVERY OF POORLY SOLUBLE DRUGS. US 62/395,202
  3. Wang AZ, et al. Biomatrix scaffolds for use in diagnosing and modeling cancer background. US 62/361,306
  4. Wang AZ, Mohr J, Gabizon A. Combination Therapy Comprising a Lipsomal Prodrug of Mitomycin C and Radiotherapy. US 62/120,637
  5. Wang AZ, Min Y. Antigen capturing nanoparticles to improve cancer immunotherapy. US62/256944, PCT/US16/62563
  6. Wang AZ, Eblan M. Circulating Tumors Cells as Predictive Biomarker for Response to Radiation with or without chemotherapy. US 62/161595
  7. Wang AZ et al. Treatment of cancer. US 61/883487
  8. Wang Y, Reid LM, Yamauchi M, Cui C, Wang AZ, Werner M. Biomatrix Scaffolds. US 13/807,260 (07/11).
  9. Wang Z, Pacold M, Werner M, Karve S. Novel Wortmannin Nanoparticles and Uses Thereof. US PCT/US2011/ 61431689 (01/2011).
  10. Wang Z, Werner M, Chen R, Byrne J, Karve S, Desimone J. Delivery for brachytherapy and associated methods. International PCT Patent Application No.: PCT/US2010/053357 (10/2010).
  11. Wang AZ, Farokhzad OC, Zhang LF, Radovic-Moreno A, Gu F, Langer R. Drug delivery system for pharmaceuticals and radiation. International PCT Patent Application No.: PCT/US08/082655 (12/2008).