X. Sha Chang, Ph.D.

Associate Professor and Head of Physics & Computing Division

Sha ChangContact

Phone: (919) 966-0400
Fax: (919) 966-7681
E-mail: Sha_Chang@med.unc.edu
Web Site

Education and Degrees

BS (Physics): Nanking University, Nanking, China
PhD (Solid State Physics): Clark University, Massachusetts, USA
Medical Physics Residency: The Joint Center for Radiotherapy, Harvard Medical School, Massachusetts, USA

Areas of Interest

  • Carbon nanotube field emission irradiation device development
  • Animal model and cellular irradiation technology
  • IMRT dose optimization
  • IMRT treatment delivery including compensator-IMRT
  • Adaptive radiotherapy
  • Radiotherapy treatment planning system development
  • Radiotherapy physics teaching

Recent Publications (peer-reviewed)

  1. S. Wang and S. Chang Effects of hydrogen post treatment and duty factor on carbon nanotube field emission stability, Mater. Res. Soc. Symp. Proc., Vol. 963 Q20.50-1-6 (2007)
  2. S. Chang, J. Zhang, D. Bordelon, E. Schreiber, A. Cox, O. Zhou. “Development of a carbon nanotube based low -LET multi-pixel microbeam array”, Rad. Res. 166, 658-659 (2006)
  3. J. Zhang, G. Yang, Y. Lee, S. Chang, J.P. Lu, and O. Zhou. “Multiplexing radiography using a carbon nanotube based x-ray source”; Applied Physics Letters, 89, 064106, (2006)
  4. JK Horton, JS Halle, S. Chang, CI Sartor “Comparison of three concomitant boost techniques for early-stage breast cancer”, Int. J Radiat Oncol Biol Phys, 64 (1), 168-75 (2006)
  5. S. Chang, J. Zhang, D. Bordelon, E. Schreiber, A. Cox, O. Zhou. Development of a nanotechnology based low-LET multi-microbeam array single cell irradiation system, Radiation Protection Dosimetry Vol. 122(1-4), pp. 323-326 (2006)
  6. M. Foskey, B. Davis, L. Goyal, S. Chang, E. Chaney, N. Strehl, S. Tomei, J. Rosenman, and S.Joshi. Large deformation 3D image registration in image-guided radiation therapy. Physics in Medicine and Biology 50:5869–5892 (2005)
  7. B. Davis, M. Foskey, J. Rosenman, L. Goyal, S. Chang, and S. Joshi. Automatic segmentation of intra-treatment CT images for adaptive radiation therapy of the prostate. In Medical Image Computing and Computer-Assisted Intervention, Lecture Notes in Computer Science 3749, 442–450 (2005)
  8. Sha Chang, Timothy Cullip, Katharin Deschesne, Elisabeth Miller, Julian Rosenman.  Compensators: An alternative IMRT delivery technique. Journal of Applied Clinical Medical Physics, Vol. 5(3), pp15 –36 (2004) (Nominated as the best paper of the journal in 2004)
  9. Shiva D, Cullip T, Tracton G, Chang S, Marks L, Abscher M, Rosenman J. Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization. Int. J. Radiation Oncology Biol. Phys. Vol. 55(1), pp 215-224 (2003)
  10. Sha X. Chang, Timothy J. Cullip, Julian G. Rosenman, Per H. Halvorsen, Joel E. Tepper. Dose Optimization via Index-Dose Gradient Minimization. Medical Physics Vol. 29(6), pp/1130-1146 (2002)
  11. G.Z. Yue, Q. Qiu, B. Gao, Y. Cheng, J. Zhang, H. Shimoda, S. Chang, J.P. Lu, and O. Zhou. “Generation of continuous and pulsed diagnostic imaging x-ray radiation using a carbon-nanotube-based field-emission cathode”, Appl. Phys. Lett. Vol. 81, No. 2, 355 (2002 ) (Selected as one of the highlights of physics research in 2002 by Physics News)
  12. Larry Potter, Sha Chang, Timothy Cullip, Alfredo Siochi.  Quality and Efficiency Analysis of the IMFAST ™ Segmentation Algorithm in Head and Neck “step & shoot” IMRT treatment, Medical Physics Vol. 29(3), pp. 275-283 (2002)
  13. Sha X Chang, Timothy J. Cullip, and Katharin Deschesne. Intensity modulation techniques: “Step & Shoot” MLC Auto-Sequence versus the Use of a Modulator, Medical Physics, Vol. 27(5), pp. 948-959 (2000)
  14. Sha Chang, Kathy Deschesne, Tim Cullip, Stephanie Parker, and Jon Earnhart. A Comparison of Different Intensity Modulation Treatment Techniques for Tangential Breast Irradiation, International Journal of Radiation Oncology. Biology, Physics Vol. 45(5), pp. 1305-1314 (1999)

Projects

Chang awarded 3-year NCI grant
To develop carbon nanotube micro-RT technology for use in miniature CT scanners.
Chang awarded patent
This novel device has the potential to accelerate cancer cell biology research worldwide.
Chang elected SEAAPM Chapter President
Chapter spans six states.
Chang and Zhou awarded GO grant from NCI
Prestigious $2M Grand Opportunity grant for a novel micro-RT brain tumor irradiator.
Snyder honored for nanotechnology-based cell irradiator
Are cancer cells are more sensitive to microbeam radiation than normal cells?
Nanoparticles Promise Delivery of Abandoned Cancer Drug
A team of UNC researchers developed nanoparticle carriers to successfully deliver therapeutic doses of a cancer drug that had previously failed clinical development due to pharmacologic challenges.
Tepper and DeSimone awarded $13.6M nanotechnology grant
from the National Cancer Institute.
Jian Zhang Receives 2007 AAPM Reviewer’s Choice Award
Zhang speeds up CT imaging with a paper ranked 8th of 1100 papers.
Single cell irradiation
Goal: To develop a novel multi-pixel single cell microbeam irradiation system that can irradiate many individually selected single cells or cellular regions simultaneously or in a time sequence under microscope observation.
Micro-RT irradiation
Goal: To develop a high spatial and temporal resolution micro-RT system for small animal model radiation research using nanotube field emission technology.
Related CNT field emission research projects
The Otto Zhou Research lab, in the UNC Department of Physics & Astronomy, develops carbon nanotubes (CNT) and nanowires into novel devices: research, people, publications, facilities.
Chang receives new patent for microbeam irradiator