Education and Degrees
BS (Physics): Nanking University, Nanking, China
PhD (Solid State Physics): Clark University, Massachusetts, USA
Medical Physics Residency: The Joint Center for Radiotherapy, Harvard Medical School, Massachusetts, USA
Areas of Interest
- Carbon nanotube field emission irradiation device development
- Animal model and cellular irradiation technology
- IMRT dose optimization
- IMRT treatment delivery including compensator-IMRT
- Adaptive radiotherapy
- Radiotherapy treatment planning system development
- Radiotherapy physics teaching
Recent Publications (peer-reviewed)
- S. Wang and S. Chang Effects of hydrogen post treatment and duty factor on carbon nanotube field emission stability, Mater. Res. Soc. Symp. Proc., Vol. 963 Q20.50-1-6 (2007)
- S. Chang, J. Zhang, D. Bordelon, E. Schreiber, A. Cox, O. Zhou. “Development of a carbon nanotube based low -LET multi-pixel microbeam array”, Rad. Res. 166, 658-659 (2006)
- J. Zhang, G. Yang, Y. Lee, S. Chang, J.P. Lu, and O. Zhou. “Multiplexing radiography using a carbon nanotube based x-ray source”; Applied Physics Letters, 89, 064106, (2006)
- JK Horton, JS Halle, S. Chang, CI Sartor “Comparison of three concomitant boost techniques for early-stage breast cancer”, Int. J Radiat Oncol Biol Phys, 64 (1), 168-75 (2006)
- S. Chang, J. Zhang, D. Bordelon, E. Schreiber, A. Cox, O. Zhou. Development of a nanotechnology based low-LET multi-microbeam array single cell irradiation system, Radiation Protection Dosimetry Vol. 122(1-4), pp. 323-326 (2006)
- M. Foskey, B. Davis, L. Goyal, S. Chang, E. Chaney, N. Strehl, S. Tomei, J. Rosenman, and S.Joshi. Large deformation 3D image registration in image-guided radiation therapy. Physics in Medicine and Biology 50:5869–5892 (2005)
- B. Davis, M. Foskey, J. Rosenman, L. Goyal, S. Chang, and S. Joshi. Automatic segmentation of intra-treatment CT images for adaptive radiation therapy of the prostate. In Medical Image Computing and Computer-Assisted Intervention, Lecture Notes in Computer Science 3749, 442–450 (2005)
- Sha Chang, Timothy Cullip, Katharin Deschesne, Elisabeth Miller, Julian Rosenman. Compensators: An alternative IMRT delivery technique. Journal of Applied Clinical Medical Physics, Vol. 5(3), pp15 –36 (2004) (Nominated as the best paper of the journal in 2004)
- Shiva D, Cullip T, Tracton G, Chang S, Marks L, Abscher M, Rosenman J. Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization. Int. J. Radiation Oncology Biol. Phys. Vol. 55(1), pp 215-224 (2003)
- Sha X. Chang, Timothy J. Cullip, Julian G. Rosenman, Per H. Halvorsen, Joel E. Tepper. Dose Optimization via Index-Dose Gradient Minimization. Medical Physics Vol. 29(6), pp/1130-1146 (2002)
- G.Z. Yue, Q. Qiu, B. Gao, Y. Cheng, J. Zhang, H. Shimoda, S. Chang, J.P. Lu, and O. Zhou. “Generation of continuous and pulsed diagnostic imaging x-ray radiation using a carbon-nanotube-based field-emission cathode”, Appl. Phys. Lett. Vol. 81, No. 2, 355 (2002 ) (Selected as one of the highlights of physics research in 2002 by Physics News)
- Larry Potter, Sha Chang, Timothy Cullip, Alfredo Siochi. Quality and Efficiency Analysis of the IMFAST ™ Segmentation Algorithm in Head and Neck “step & shoot” IMRT treatment, Medical Physics Vol. 29(3), pp. 275-283 (2002)
- Sha X Chang, Timothy J. Cullip, and Katharin Deschesne. Intensity modulation techniques: “Step & Shoot” MLC Auto-Sequence versus the Use of a Modulator, Medical Physics, Vol. 27(5), pp. 948-959 (2000)
- Sha Chang, Kathy Deschesne, Tim Cullip, Stephanie Parker, and Jon Earnhart. A Comparison of Different Intensity Modulation Treatment Techniques for Tangential Breast Irradiation, International Journal of Radiation Oncology. Biology, Physics Vol. 45(5), pp. 1305-1314 (1999)
- Chang awarded 3-year NCI grant
- To develop carbon nanotube micro-RT technology for use in miniature CT scanners.
- Chang awarded patent
- This novel device has the potential to accelerate cancer cell biology research worldwide.
- Chang elected SEAAPM Chapter President
- Chapter spans six states.
- Chang and Zhou awarded GO grant from NCI
- Prestigious $2M Grand Opportunity grant for a novel micro-RT brain tumor irradiator.
- Snyder honored for nanotechnology-based cell irradiator
- Are cancer cells are more sensitive to microbeam radiation than normal cells?
- Nanoparticles Promise Delivery of Abandoned Cancer Drug
- A team of UNC researchers developed nanoparticle carriers to successfully deliver therapeutic doses of a cancer drug that had previously failed clinical development due to pharmacologic challenges.
- Tepper and DeSimone awarded $13.6M nanotechnology grant
- from the National Cancer Institute.
- Jian Zhang Receives 2007 AAPM Reviewer’s Choice Award
- Zhang speeds up CT imaging with a paper ranked 8th of 1100 papers.
- Single cell irradiation
- Goal: To develop a novel multi-pixel single cell microbeam irradiation system that can irradiate many individually selected single cells or cellular regions simultaneously or in a time sequence under microscope observation.
- Micro-RT irradiation
- Goal: To develop a high spatial and temporal resolution micro-RT system for small animal model radiation research using nanotube field emission technology.
- Related CNT field emission research projects
- The Otto Zhou Research lab, in the UNC Department of Physics & Astronomy, develops carbon nanotubes (CNT) and nanowires into novel devices: research, people, publications, facilities.