Focus on research methodology

As stated in the introduction, regenerative medicine encompasses multiple research pathways.  It runs the spectrum from basic (cell to animal models) to clinical (animal and human).  This is why teams of investigators from different approaches are so important for moving this research forward to the next level.  We hope the information in this website gives you a better understanding of current research at NCSU and UNC.  If you are looking for a collaborator(s), we hope the information here will help you identify possible contacts.  For links and contact information on specific investigators, please see the People section.


Both UNC and NCSU investigators are engaged in a variety of basic cellular research areas, including: nanotechnology-Paul Cohen, Jingyan Dong, Troy Ghashghaei, Russell Gorga, Thom LaBean, Melissa Pasquinelli, Jorge Piedrahieta, Lauren Schnabel; proteomics-Balji Rao, Xian Chen; signal transduction-Nancy Allbritton and stem cells-Sai Chavala, Bill Coleman, David Gerber, Shawn Hingtgen, Elizabeth Laboa, P. Kay Lund, Scott Magness, Lola Reid, Anna Spagnoli and John van Aalst.  Other investigators engaged in cellular structure and functions include: Mansoor Haider (applied mathematics), Jon Horowitz, Mohanish Deshmukh, Andrew Dudley (cancer research), and Joel Pawlak (materials sciences). Many of the NCSU investigators involved in nanotechnology are in the College of Textiles.  UNC investigators engaged in nanotechnology are members of the Carolina Institute for Nanomedicine.


Animal models research is very strong at both NCSU and UNC.  Projects range from the cellular mechanics, to systemic processes to clinical treatment.  Basic investigators at NCSU include: Mathew Gerard (Gastrointestinal), Seth Kullman (Genomics), Chris McGahan (Eye), Jorge Piedrahita (Genomics), Marcelo Rodriguez-Puebla (Dermatology).  UNC investigators include: Aravinda Asokan (Gene Therapy); Scott Bultman (Genetics); Mohanish Deshmukh (Neuroscience/Oncology); Jiandong Liu (Cardiovascular); Temitope Keku, Scott Magness, R. Balfour Sartor (Gastrointestinal) and Ted Bateman (Osteoporosis).

Other areas of basic research include: biomedical devices-Behnam Pourdehymi, Rohan Shirwaiker, Binil Starly, Rick Wysk, Robert Young; Cardiology-Ke Cheng; and Ophthalmology-Brian Gilger.  Faculty engaged in development of biomedical devices are primarily in the College of Engineering, Industrial & Systems Engineering.


Clinical research is more focused on disease progression and treatment.  Most of the investigators in clinical animal research are from the NCSU College of Veterinary Medicine and are practicing veterinarians.  Areas of research and investigators include:  Bone-Duncan Lascelles, Denis Marcellin-Little, Simon Roe; Cancer-Steve Suter; Cardiology-Teresa DeFrancesco, Bruce Keene, Steve Marks; Gastrointestinal-Anthony Blikslager, Jody Gookin; Hematology-Karyn Harrell; Neurology-Chris Mariani, Natasha Olby; Ophthalmology-Brian Gilger; Orthopedics-Lauren Schnabel; Postop/Pain-Lizette Hardie; Renal-Kathy Lunn, Shelly Vaden, Mike Wood; Soft-tissue surgery-Kyle Matthews.


The clinical research involving human studies are more prevalent at the UNC School of Medicine.  Most clinical faculty engaged in research are members of at least one of the Centers in the School.  These Centers are organized primarily around disease  areas.  Investigators involved in regenerative medicine human studies include: Ophthalmology-Sai Chavala, Gastrointestinal-R. Balfour Sartor, Neurology-Jing Wu, Pediatrics-Ajay Gulati, Anna Spagnoli, Surgery-Chris Dekaney, David Gerber, John van Aalst