The Wolf and Daisy Losken Craniofacial Research Fellowship was inaugurated in 2006 in order to celebrate the work of Dr. Wolfgang Losken, who was the UNC Division of Plastic Surgery Craniofacial Surgeon from 2000 to 2006. When Dr. Losken retired, he was asked what he would most like to be remembered for; his immediate response was “Research.”
The Fellowship provides the opportunity for the Research Fellow to spend a year performing basic science research in Craniofacial Tissue Engineering. Our laboratory is interested in providing tissue engineered solutions for craniofacial bone and cartilage defects, as well as providing tissue engineered skin for complex wounds.
Selected publications from the laboratory include the following:
Caballero M, Reed CR, Madan G, van Aalst JA. Osteoinduction in Umbilical Cord-and Palate Periosteum-Derived Mesenchymal Stem Cells, Annals of Plastic Surgery, 64(5):605-9, 2010.
Reed CR, Han L, Andrady A.Caballero M, Jack MC, Collins JB, Saba SC, Loboa EG, van Aalst JA. “Composite Tissue Engineering on Polycaprolactone Nanofiber Scaffolds,” Annals of Plastic Surgery, 62(5):505-12, 2009.
Hanson AD, Marvel SW, Bernacki SH, Banes AJ, van Aalst JA, Loboa EG. "Osteogenic Effects of Rest Inserted and Continuous Cyclic Tensile Strain on hASC Lines with Disparate Osteodifferentiation Capabilities," Annals of Biomedical Engineering, 2009 Feb 20.
Hromadka M, Collins JB, Reed C, Han L, Kolappa KK, Cairns BA, Andrady T, van Aalst JA. “Nanofiber Applications for Burn Care,” J Burn Care Res, September/October;29(5):695-703, 2008.
van Aalst JA, Reed C, Han L, Andrady T, Hromadka M, Bernacki S, Loboa EG, Bernacki S, Hromadka M, Kolappa KK, Collins JB. “Cellular Incorporation Into Electrospun Nanofibers: Retained Viability, Proliferation and Function in Fibroblasts,” Annals of Plastic Surgery, Ann Plast Surg. 2008 May;60(5):577-83
Selected grants received by the laboratory include the following:
- “Inflammation Resistant Osteoblast-Osteoclast Nano-Engineered Bone.”
Sponsor: UNC/NIH: 5KL2RR025746-03
- “Stem Cell Solutions to the Formation of Heterotopic Ossification in Burn Patients.”
Sponsor: North Carolina Jaycee Burn Center
- “Flexible Cartilage in Microtia Repair: Umbilical Cord Stem Cells on Nano-Implants.”
Sponsor: American Academy of Otolaryngology: Head and Neck Cancer Foundation
- “Keratinogenesis from SSEA-4+ Umbilical Cord-Derived Mesenchymal Stem Cells.”
Sponsor: University of North Carolina, NCTracs Institute
- “Umbilical Cord Mesenchymal Stem Cell Osteoinduction on PLGA Nanofibers.”
Sponsor: Stryker Leibinger
- “Umbilical Cord Blood Derived Stem Cell Incorporation into Nanofibers Scaffolds: Induction of Osteogenesis for Craniofacial Defects,”
Bernd Spiessel Award
Sponsor: American Society of Maxillofacial Surgeons
- “Umbilical Cord Blood Derived Stem Cell Incorporation into Nanofibers for the Induction of Chondrogenesis”
David W. Furnas Award
Sponsor: American Association of Plastic Surgeons