Teresa Tarrant, MD, of the Thurston Arthritis Research Center has been selected as the 2013 recipient of the American College of Rheumatology Research and Education Foundation (ACR REF) Disease Targeted Research Grant. This grant is part of a multi-year research initiative, Within Our Reach: Finding a Cure for Rheumatoid Arthritis, which will fund over $30 million to accelerate high-risk, high-reward research in inflammatory arthritis. Advancing research in this important area will enhance the practicing rheumatologistâ€™s ability to recognize various causes of the disease, predict onset of disease, individualize treatment, prevent joint damage, and improve joint function. Funded research is expected to address basic, translational and clinical aspects of inflammatory arthritis and lead to new insights into the etiology, pathogenesis and treatment of these diseases.
Dr. Tarrant's project, "Validating GPSM3 as a Key Regulator of Monocyte-driven Inflammatory Arthritis", will be funded for two years with this $400,000 grant. This project will explore how a newly discovered protein, GPSM3, may serve as a potential target to treat patients with inflammatory arthritis through its regulation on monocyte function. This research may identify new pathways that can more specifically inhibit unwanted inflammation in autoimmune disease.