News

Site News

Dr. Amanda Nelson and Dr. Yvonne Golightly Lead the Johnston County Osteoarthritis Project as Co-Principal Investigators

For more than 25 years, the Johnston County Osteoarthritis Project has established itself as one of the premier longitudinal research studies world-wide regarding the causes, societal implications, and means of addressing the impact of osteoarthritis. Ongoing research is providing important new insights regarding how osteoarthritis is diagnosed and assessed clinically, as well as how it can be addressed in community settings.
Dr. Amanda Nelson and Dr. Yvonne Golightly Lead the Johnston County Osteoarthritis Project as Co-Principal Investigators  click to enlarge Amanda Nelson, MD, MSCR, RhMSUS; and Yvonne Golightly, PT, MS, PhD

The Johnston County Osteoarthritis Project was initiated in 1990 and led for 27 years by Dr. Joanne M. Jordan, who was the principal investigator, and who also served as Director of the UNC Thurston Arthritis Research Center as well as Chief of the UNC Rheumatology, Allergy and Immunology Division.  With Dr. Jordan’s promotion to the role of Vice Dean in the Office of Faculty Affairs and Leadership Development, the Johnston County Osteoarthritis Project is now being led by two Co-Principal Investigators with the UNC Thurston Arthritis Research Center: Rheumatologist Amanda Nelson, MD, MSCR, RhMUS; and Epidemiologist Yvonne Golightly, PT, MS, PhD.  Dr. Jordan remains a co-investigator for the research project.   

“I am thrilled to have two highly skilled investigators to take the reins of this long-standing project, and I am eagerly anticipating how they will shape the next 25 years of this unique community-university partnership,” says Dr. Jordan.

Both Drs. Nelson and Golightly have worked with the Johnston County Osteoarthritis Project since 2006 and together have authored 33 publications based on findings from this project.  Research performed in Johnston County, NC, has been the source of over 70 supplementary and ancillary studies as well as more than 200 publications.  

“Our research is unique because we are bringing to bear a vast repository of population-based data, paired with the latest findings that are being made available thanks to innovative analytic methods and application of imaging and other technologies,” says Dr. Nelson.  "As a result, we are gaining valuable insights that help better inform how we evaluate and treat patients with osteoarthritis.” 

Dr. Golightly, who combines her research background with training as a physical therapist, adds that a key goal of the Johnston County Osteoarthritis Project is to identify interventions that patients can implement in their daily lives. 

“In addition to learning about the causes and implications of osteoarthritis, we want to know more about what can realistically be done now – in real-world community settings – to reduce the impact of this disease on patients here, and across the country,” says Dr. Golightly.

Drs. Nelson and Golightly are leading efforts to begin enrollment of new participants, in order to address naturally-occurring attrition as well as to also include a younger cohort of participants, starting at age 35.  This new cohort in Johnston County will include White, African American, and for the first time, Hispanic men and women.   

Read more about the Johnston County Osteoarthritis Project via this link.

Arthritis Researcher Brian Diekman, PhD, Awarded Grant to Explore Common Mechanisms of Aging

Aging is the greatest risk factor for osteoarthritis, but little is known about how specific age-related changes to cells cause the breakdown of cartilage. The research funding provided by a grant from the American Federation for Aging Research (AFAR) will enable Dr. Diekman to study mechanisms of aging across different tissue systems. The hope is that this type of research will help play a role in advancing new discoveries that can help prevent and better treat all forms of arthritis. (More...)

Learn more about Dr. Diekman's research as well as the grant received from AFAR via this link.

You can also read an article regarding Dr. Diekman's work that was recently published by the Arthritis National Research Foundation, via this link.

Several Studies Authored by TARC and Osteoarthritis Action Alliance Researchers Are Published in North Carolina Medical Journal

Topics covered range from whether Osteoarthritis (OA) might be a predictor of mortality, challenges associated with management of the disease, the impact of musculoskeletal health on disability, and implications of obesity on musculoskeletal health. (More...)

Thurston Arthritis Research Center (TARC) and Osteoarthritis Action Alliance experts whose research was included are:  

-Rebecca Cleveland, PhD, and Leigh Callahan, PhD:  Can Osteoarthritis Predict Mortality? 

-Reshmi Raveendran, MD; and Amanda Nelson, MD, MSCR:  Lower Extremity Osteoarthritis - Management and Challenges.  https://t.co/10ZkxFivD9

-Kelli Allen, PhD:  Musculoskeletal Health - Addressing the Leading Causes of Disability.  https://t.co/WL7I83f6Nj      

-Kirsten Ambrose, MS:  Where Does it Hurt?  Implications of Obesity on Musculoskeletal Health.  http://bit.ly/2lbBIH1 

 

Kelli Allen, PhD, Is Among the Leading Researchers Involved in Innovative Studies of Pain Management Interventions for Members of the Military and Veterans

Members of the military and veterans are disproportionally affected by pain, and the government is searching for ways to help them deal with this widespread and growing problem. New research being conducted thanks to multiple grants recently awarded by DHHS, the Department of Defense, and the VA will help investigate the feasibility, safety and effectiveness for a number of non-drug approaches for pain management and related conditions. (More…)

Among the types of approaches being studied are mindfulness/meditation, movement interventions such as yoga and tai chi, massage, acupuncture, and cognitive behavior therapy.  Dr. Allen is part of a collaborative team that includes investigators at the U.S. Department of Veteran's Affairs in Durham, NC, as well as Duke University's School of Medicine, with a project aimed at improving access to appropriate non-pharmacological therapies for veterans with back pain. 

"Collectively, this research has the potential to help define which types of non-drug pain interventions can make the greatest difference for the millions of veterans and members of the military whose quality of life has been impacted by chronic pain,” said Dr. Allen, who is a Research Professor of Medicine and faculty member at the UNC Thurston Arthritis Research Center.  Additional information about the research involved in this initiative is available via this news release.



Lupus Patients Have the Option to Administer the Medication Benlysta Themselves at Home, Thanks in Part to the Efforts of Dr. Saira Sheikh

Lupus patients who previously needed to visit an infusion center to receive the drug Benlysta, now have the option to administer the medicine themselves at home using a novel "auto-injector" device, thanks in part to the efforts of Dr. Saira Sheikh, who is a rheumatologist and allergist/immunologist at UNC, and who also directs the Lupus and Clinical trials programs at the UNC Thurston Arthritis Research Center. (More...)

Dr. Sheikh was recently invited to share her expertise during an educational session at the live national broadcast of the launch of the subcutaneous Benlysta auto-injector, in which she discussed day-to-day challenges faced by lupus patients, therapeutic approaches in lupus, and the Benlysta auto-injector clinical trial. Dr Sheikh was Principal Investigator on the clinical trial and first author on the research paper (http://bit.ly/2fiBwk3) outlining the patient experience with the auto-injector device.   

Dr. Scott Commins Discusses Alpha-Gal Meat Allergy in New Podcast

Dr. Scott Commins describes alpha-gal allergy, which scientists believe is triggered by a tick bite and can cause an allergic reaction to red meat. Dr. Commins talks about the symptoms of a reaction, how a person can be tested for the allergy, and changes in diet recommended for patients who have alpha-gal. (More...)

Dr. Scott Commins, a leading expert on this unusual allergy, is an Associate Professor of Medicine in UNC's Division of Rheumatology, Allergy and Immunology, and a faculty member of the UNC Thurston Arthritis Research Center. You can listen to his podcast by clicking this link:  http://unc.live/2fghs1O

  

 

Arthritis Foundation Spotlights Dr. Richard Loeser's Research Into the Potential Role of "Gut Bacteria" in Osteoarthritis

We know that different factors such as aging and injury can have an impact on whether or not a person develops osteoarthritis, as well as the progression of their disease. But could the composition of the bacteria in a person’s “gut” have an impact as well? (More...)

Innovative research being conducted by Richard Loeser, MD, and his team are exploring the differences in the collection of gut bacteria (sometimes referred to as the ‘microbiome’) of overweight and obese people who have osteoarthritis compared with those do not have the disease.  An article recently posted by the Arthritis Foundation provides additional information regarding this intriguing research.  Click this LINK to read the article.  

Dr. Joanne Jordan Receives American Medical Association’s (AMA) “Inspirational Physician” Award

Each year the AMA’s Women Physicians Section honors outstanding doctors who are recognized for having offered their time, wisdom and support to advance women with careers in medicine. Dr. Joanne Jordan was selected as a recipient of the 2017 “Inspirational Physician” Award, which serves as a platform to showcase the accomplishments of women physicians, and highlights advocacy needs related to professional concerns of women physicians and health issues affecting women patients.

"Dr. Jordan has been an invaluable mentor to trainees at many levels, including medical students, fellows, graduate students, and junior faculty in a variety of health-related fields,” said Dr. Amanda Nelson, who nominated Dr. Jordan.  "She is an ideal role model for women physicians, and could not be more deserving of this award."

Dr. Jordan is the Joseph P. Archie, Jr. Eminent Professor of Medicine at UNC, as well as Vice Dean for Faculty Affairs and Leadership Development, and an adjunct professor of epidemiology.  

The UNC Thurston Arthritis Research Center Receives $4M in NIH Funding to Continue Researching the Mechanisms Responsible for Cartilage Destruction in Osteoarthritis

Dr. Richard Loeser, a rheumatologist and investigator who heads the UNC Thurston Arthritis Research Center, has been awarded grants totaling $4 million from the National Institutes of Health (NIH) for two osteoarthritis projects.
The UNC Thurston Arthritis Research Center Receives $4M in NIH Funding to Continue Researching the Mechanisms Responsible for Cartilage Destruction in Osteoarthritis click to enlarge Richard Loeser, Jr., MD, is director of the UNC Thurston Arthritis Research Center and Herman and Louise Smith Distinguished Professor in the division of rheumatology, allergy and immunology

Dr. Richard Loeser, a rheumatologist and investigator who heads the UNC Thurston Arthritis Research Center, has been awarded grants totaling $4 million from the National Institutes of Health (NIH) for two projects focused on improving our understanding of the basic mechanisms responsible for cartilage destruction in people with osteoarthritis.  These projects seek to discover new targets for therapies that will stop the production of inflammatory factors and enzymes that degrade cartilage in patients with osteoarthritis.  The awards will fund the continuation of this research for an additional five years.

Part of the research focuses on improving scientists’ understanding of the signals within cells responsible for activating these destructive processes.  The “Integrin Function in Cartilage” project explores how damage to the matrix surrounding cartilage cells (called chondrocytes) stimulates signals from cell receptors (called integrins), which then utilize reactive oxygen species (free radicals) to regulate the activity of the signalling pathways.  The project includes a collaboration with Dr. Cathy Carlson at the University of Minnesota. 

A related project, named “Oxidative Stress and the Development of Osteoarthritis,” considers how an increase in the reactive oxygen species within cartilage cells during the aging process can alter signals that control cartilage breakdown and chondrocyte survival.  This project includes a collaboration with investigators at Wake Forest School of Medicine, the University of Minnesota, and Rush Medical College. 

“Osteoarthritis is the number one cause of disability among older adults,” said Dr. Loeser, Herman and Louise Smith Distinguished Professor in the division of rheumatology, allergy and immunology.  “We are particularly pleased to have the opportunity to continue this research because at the current time we lack any treatment that can slow or stop the progression of this common condition that affects over 30 million Americans.”

WUNC Public Radio Interviews Dr. Scott Commins Regarding Poorly Understood "Alpha-gal" Meat Allergy

UNC is one of only several locations in the United States that is conducting clinical studies of a meat allergy some people develop after being bitten by a tick. Dr. Scott Commins, a researcher and leading expert on this unusual food allergy, was recently interviewed by WUNC Public Radio to help increase public awareness for an increasingly common health condition that too often goes undiagnosed.

To hear the interview and learn more about alpha-gal meat allergy, click this Link

Filed under: