Joanne M. Jordan, MD, MPH of the UNC Thurston Arthritis Research Center; Stephen W. Marshall, PhD of the UNC Injury Prevention Research Center; and Jeffrey T. Spang, MD of UNC Orthopaedics have been awarded a TraCS Planning Grant for a collaborative study titled Biomarker and Biomechanical Predictors of Osteoarthritis in ACL-Injured Patients. This grant will establish an interdisciplinary research infrastructure designed to collect biomarker and biomechanical data on patients undergoing ACL (anterior cruciate ligament) reconstruction. Patients will be enrolled following ACL injury and prior to ACL reconstruction surgery. The study will collect samples for biomarker analysis prior to surgery, detailed information about articular cartilage and meniscus damage, as well as fluid samples, during surgery; and evaluate biomechanics six months after surgery. The study will help to establish the relationship between levels of biomarkers, extent of cartilage damage and future development of osteoarthritis.
The North Carolina Translational and Clinical Sciences (NC TraCS) Institute is one of approximately 60 Clinical and Translational Science Awards (CTSA) medical research institutions working together as a national consortium to improve the way biomedical research is conducted across the country. The Consortium members share a common vision to reduce the time it takes for laboratory discoveries to become treatments for patients, and to engage communities in clinical research efforts.