Amanda E. Nelson, MD, MSCR

Amanda E. Nelson, MD, MSCR

Assistant Professor of Medicine
Office: Thurston Arthritis Research Center
3300 Thurston Building, Campus Box 7280
Chapel Hill NC 27599-7280

Clinic Location: Carolina Pointe II
6013 Farrington Rd #301
Chapel Hill , NC 27517
Appointment Phone: 984-974-4191

UNC Health Care Profile & Star Rating

Specialty Areas: general rheumatology, rheumatoid arthritis, spondyloarthropathies, osteoarthritis, crystalline arthropathies, polymyalgia rheumatica, musculoskeletal ultrasound, epidemiology

Chronology: BA Magna Cum Laude, Studio Art: The Colorado College, 1997; MD: Vanderbilt University Medical Center, 2002; Internal Medicine Internship: University of South Alabama, 2002-2003; Nuclear Medicine Residency: Northwestern University, 2003-2004; Internal Medicine Residency: Virginia Mason Medical Center, 2004-2006; Rheumatology Fellowship: University of North Carolina, 2006-2009; Clinical Assistant Professor of Medicine: University of North Carolina, 2009-2013; Assistant Professor of Medicine: University of North Carolina, 2013-present.

Description of research and/or clinical interests:  Dr. Nelson is a board-certified internist and rheumatologist with a Masters in Clinical Research in epidemiology. She has a half day per week general rheumatology clinic as well as a twice monthly half day musculoskeletal ultrasound clinic, and is involved in fellow education.  Dr. Nelson’s research is focused on a variety of aspects of imaging in osteoarthritis (OA), including the contribution of bone shape to OA risk, novel methodologies for analysis of imaging data, and assessment of whole-body burden of OA.  She has also done work involving serum biomarkers of OA, and investigated racial and gender differences in imaging and other aspects of OA. 

Selected Bibliography:

Nelson AE, Stiller JL, Shi XA, Leyland KM, Renner JB, Schwartz TA, Arden NK, Jordan JM. Measures of hip morphology are related to development of worsening radiographic hip osteoarthritis over 6 to 13 year follow-up: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2015 Oct 20. pii: S1063-4584(15)01357-6. doi: 10.1016/j.joca.2015.10.007. [Epub ahead of print]

Ogdie A, Shah AA, Makris UE, Jiang Y, Nelson AE, Kim AHJ, Angeles-Han S, Castelino FV, Golding A, Muscal E, Kahlenberg JM, Barg FK.  Barriers and Facilitators of a Career as a Physician Scientist Among Rheumatologists in the United States.  Arthritis Care Res 2015;67(9):1191-1201, doi: 10.1002/acr.22569.

Golightly YM, Allen KD, Nyrop KA, Nelson AE, Callahan LF, Jordan JM.  Patient-reported outcomes to initiate a provider-patient dialog for the management of hip and knee osteoarthritis.  Semin Arthritis Rheum 2015;45(2):123-31, doi: http://dx.doi.org/10.1016/j.semarthrit.2015.04.008.

Lane NE, Hochberg MC, Nevitt MC, Simon LS, Nelson AE, Doherty M, Herontin Y, Flechsenhar K. OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hip osteoarthritis. Osteoarthritis Cartilage 2015;23(5):761-771, doi: 10.1016/j.joca.2015.03.006.

Kloppenburg M, Maheu E, Kraus VB, Cicuttini F, Doherty M, Dreiser RL, Henrotin Y, Jiang GL, Mandl L, Martel-Pelletier J, Nelson AE, Neogi T, Pelletier JP, Punzi L, Ramonda R, Simon LS, Wang S. OARSI Hand Clinical Trial Recommendations Work Group. OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis. Osteoarthritis Cartilage 2015;23(5):772-786. doi: 10.1016/j.joca.2015.03.007.

Doré AL, Golightly YM, Mercer VS, Shi XA, Renner JB, Jordan JM, Nelson AE. Lower Limb Osteoarthritis and the Risk of Falls in a Community-Based Longitudinal Study of Adults with and without Osteoarthritis.  Arthritis Care Res 2015;67(5):633-9, doi: 10.1002/acr.22499. [PMC4404178]

Aslam I, Perjar I, Shi XA, Renner JB, Kraus VB, Golightly YM, Jordan JM, Nelson AE.  Associations Between Biomarkers of Joint Metabolism, Hand Osteoarthritis, and Hand Pain and Function: The Johnston County Osteoarthritis Project.  J Rheumatol 2014;41(5):938-44, doi: 10.3899/jrheum.130904. [PMC4008682]

Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM.  A systematic review of recommendations and guidelines for the management of osteoarthritis: The Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative.  Semin Arthritis Rheum 2014;43:701-12, doi: 10.1016/j.semarthrit.2013.11.012. [PMC n/a]

Nelson AE, Smith MW, Golightly YM, Jordan JM.  “Generalized Osteoarthritis”: A Systematic Review.  Semin Arthritis Rheum 2014;43:713-20, doi: 10.1016/j.semarthrit.2013.12.007. [PMC4065634]

Golightly YM, Devellis RF, Nelson AE, Hannan MT, Lohmander LS, Renner JB, Jordan JM.  Psychometric properties of the foot and ankle outcome score in a community-based study of adults with and without osteoarthritis.  Arthritis Care Res 2014, epub 9/10/13, doi: 10.1002/acr.22162. [PMC4211630]

Nelson AE, Liu F, Lynch JA, Renner JB, Schwartz TA, Lane, NE, Jordan JM. Incident symptomatic hip osteoarthritis is associated with differences in hip shape by active shape modeling: The Johnston County Osteoarthritis Project. Arthritis Care Res 2014;66(1):74-81.  DOI: 10.1002/acr.22094 [PMC3959908]

Nelson AE, Elstad E, DeVellis RF, Schwartz TA, Golightly YM, Renner JB, Conaghan PG, Kraus VB, Jordan JM.  Composite measures of multi-joint symptoms, but not of radiographic osteoarthritis, are associated with functional outcomes: The Johnston County Osteoarthritis Project. Dis Rehab 2014,36(4):300-6, epub 5/3/13, doi:10.3109/09638288.2013.790490. [PMC3735714]

Nelson AE, Golightly YM, Renner JB, Schwartz TA, Kraus VB, Helmick CG, and JM Jordan.  Differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: The Johnston County Osteoarthritis Project.  Arthritis Rheum 2013;65(2):373-7. [PMC3558926]

Nelson AE, DeVellis RF, Renner JB, Schwartz TA, Conaghan PG, Kraus VB, and JM Jordan.  Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis.  Arthritis Res Ther 2011;13:R176, doi:10.1186/ar3501 [open access].

Nelson AE, Renner JB, Schwartz TA, Kraus VB, Helmick CG, and JM Jordan.  Differences in multi-joint radiographic osteoarthritis phenotypes among African Americans and Caucasians: The Johnston County Osteoarthritis Project.  Arthritis Rheum 2011;63(12):3843-52, doi 10.1002/art.30610 [PMC3227756].

Nelson AE, Chaudhary S, Kraus VB, Fang F, Chen JC, Schwartz TA, Shi XA, Renner JB, Stabler TV, Helmick CG, Caldwell KL, Poole AR, Jordan JM.  Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and White men and women: The Johnston County Osteoarthritis Project.  Env Res 2011;111:1208-14, doi:10.1016/j.envres.2011.08.002  [PMC3210895].

Nelson AE, Shi XA, Schwartz TA, Chen JC, Renner JB, Caldwell KL, Helmick CG, Jordan JM.  Whole blood lead levels are associated with knee symptoms and radiographic knee osteoarthritis: A cross-sectional analysis in the Johnston County Osteoarthritis Project. Arthritis Res Ther 2011;13:R37, doi:10.1186/ar3270 [open access].

Nelson AE, Renner JB, Shi XA, Shreffler JH, Schwartz TA, and JM Jordan.  Cross-sectional comparison of extended anteroposterior and posteroanterior fixed-flexion positioning to assess radiographic osteoarthritis at the knee: The Johnston County Osteoarthritis Project.  Arthritis Care Res 2010;62(9):1342-5 [PMC2939919].

Nelson AE, Golightly YM, Kraus VB, Stabler T, Renner JB, Helmick CG, and JM Jordan.  Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: The Johnston County Osteoarthritis Project.  Osteoarthritis Cartilage 2010; 18:825-9 [PMC2873050].

Nelson AE, Braga L, Renner JB, Atashili J, Woodard J, Hochberg MC, Helmick CG, Jordan JM.  Characterization of individual radiographic features of hip osteoarthritis in African Americans and Whites: The Johnston County Osteoarthritis Project.  Arthritis Care Res 2010;62(2):190-7 [PMC2846079].

Nelson AE, Braga L, Braga-Baiak A, Atashili J, Schwartz TA, Renner JB, Helmick CG, and JM Jordan.  Static knee alignment measurements among Caucasians and African-Americans: The Johnston County Osteoarthritis Project.  J Rheumatol 2009;36(9):1987-90 [PMC2853360].

Nelson AE, Fang F, Shi XA, Kraus VB, Stabler T, Renner JB, Helmick CG, and JM Jordan.  Failure of serum transforming growth factor-beta (TGF-β) as a biomarker of radiographic osteoarthritis (rOA) at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project.  Osteoarthritis Cartilage 2009;17:772-6 [PMC2746496].

Jordan JM, Helmick CG, Renner JB, Luta G, Dragomir AD, Woodard J, Fang F, Schwartz TA, Nelson AE, Abbate LM, Callahan LF, Kalsbeek WD, and MC Hochberg.  Prevalence of hip symptoms and radiographic and symptomatic hip osteoarthritis in African-Americans and Caucasians:  The Johnston County Osteoarthritis Project.  J Rheumatol 2009;36(4):809-15 [PMC2957092].

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