Basic and Translational Research

The Thurston Arthritis Research Center's Basic and Translational Research program is investigating the underlying mechanisms that promote the development and progression of conditions relevant to rheumatology, allergy and immunology.

Basic and Translational Research -- Faculty and Primary Focus:   

microscope
Richard F. Loeser, Jr., MD (Director):
 
Mechanisms responsible for joint tissue destruction in osteoarthritis, including the role of aging and oxidative stress and cell signaling stimulated by matrix fragments acting through integrin receptors.  
More information about about Dr. Loeser's lab  

Scott Commins, MD, PhD:  
Food allergy to red meat; including why allergic reactions are delayed 3-6 hours after eating, and the role that tick bites may have in initiating allergic response to the carbohydrate galactose-alpha-1,3-galactose (“alpha-gal”). 
More information about Dr. Commins' lab. 

cells2Peng Liu, MD, PhD: 
Immune mechanisms that initiate and sustain tissue inflammation in rheumatoid arthritis and atherosclerosis, particularly myeloid cells, such as monocyte subsets, macrophages, dendritic cells, and myeloid-derived suppressor cells (MDSCs).  
More information about Dr. Liu's lab. 

Lara Longobardi, PhD: 
The mechanisms leading to osteoarthritis development, especially the role of chemokines in cartilage and bone generation after injury, and how they affect pain response.  
More information about Dr. Longobardi's lab.   

Doug Phanstiel, PhD: 
The manner in which DNA loops regulate monocyte differentiation, both in healthy cells and in the context of rheumatoid arthritis.  
More information about Dr. Phanstiel's lab.    
 

Affiliated Research Faculty and Primary Focus: 

Jenny Ting, PhD (Genetics):  
Innate immunity, dendritic cell function, cell death, autophagy, signal transduction.  

Barb Vilen, PhD (Microbiology and Immunology):  
Mechanisms of tolerance in systemic lupus erythematosus.

Janet Rubin, MD (Endocrinology and Metabolism):  
Metabolic bone diseases.