The Science

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Polymorphism at the GPSM3 gene locus is inversely associated with four systemic autoimmune diseases, including rheumatoid arthritis and ankylosing spondylitis. [More]

 

 

 

 

 


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Manipulating leukocyte trafficking is a promising therapeutic target for patients with autoimmune disease. Chemokines, their receptors, and intracellular regulatory proteins are critical to this process. [More]

 

 

 

 

 


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GRK3 is a critical regulator of CSCL12/CSCR4 signaling. Both humans and transgenic mice have blood and bone marrow phenotypes indicating that GRK3 could be a potential therapeutic target for hematopoietic cell transplantation. [More]

 

 

 

 

 


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Our lab has particular focus on the GRK regulation of the chemokine-receptor signaling interactions that occur between CXCR4 and its ligand CXCL12 (SDF-1). In the immunodeficiency syndrome known as WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis), ...[More]

 

 

 

 

 

 


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The CXCR4 chemokine receptor and its ligand CXCL12 (SDF-1) are critical to homeostatic migration of leukocytes, but in breast cancer, may be inappropriately utilized by invading neoplastic cells. [More]