Molecular carcinogenesis: cancer, chromatin, transcription, and epigenetics
Validate novel molecular targets (ex. oncogenic PIM kinases) for potential therapeutic intervention in pancreatic cancer and other cancers as well as test novel PIM kinase inhibitors in combination with chemotherapy.
Pharmacokinetic behavior of environmental chemicals, mechanisms of action of toxicants including endocrine disruptors, and linking of real-world exposures to health effects
Cellular response to toxic injury in the central and peripheral nervous systems; neuropathology; ocular pathology; and pathology of peripheral neuropathies
Hepatobiliary xenobiotic disposition, hepatotoxicity and pharmacokinetics
Breast and prostate carcinogenesis, macromolecular structure-function, molecular pathology
Molecular pathogenesis of liver and breast cancer, and liver progenitor cell biology
DNA replication, DNA repair, and cell cycle checkpoints in human cells; mechanisms of carcinogenesis by solar radiation; pathogenesis of melanoma
Mechanisms of air pollutant-induced adverse cardiopulmonay and neurophysiological health effects
Understanding the consequences of endocrine disruption on neurodevelopment
The role of the ras oncogne, ras-mediated signalling and ras-related small GTPases in cancer and development of anti-ras inhibitors
Regulation of programmed cell death in postmitotic, senescent, neoplastic and stem cells.
Pharmacokinetics and mechanisms of chemical-mediated toxicity and carcinogenicity
Pulmonary toxicology and molecular biology
Environmental impacts on human health, genetic susceptibility, immunology, epigenetics, translational research
Development of alternative testing methods predictive of in vivo cardiovascular toxicity of chemicals and engineered nanomaterials.
Mechanisms of health effects of environmental pollution on cardiopulmonary function, animal models of cardiovascular diseases, targeted and high throughput technology
Epidermal growth factor receptor and its ligands and signaling mechanisms of endocrine disrupting toxicants in the mammary gland
Mechanisms of induction and regulation of the innate immune response, with a focus on Toll like Receptors (TLRs).
Toxicogenomic and systems biology approaches to understanding the mechanisms of metal-induced disease and the basis for inter-individual disease susceptibility
The interaction between air pollutant exposure and the development of infectious and allergic lung disease
Chemistry of protein and DNA adducts
Role of microglia in immune-mediated responses in brain development, repair, aging and disease
Lung carcinogenesis, research translation, biomarkers, computational toxicology
Neurophysiological mechanisms mediating cardiopulmonary dysfunction due to air pollution exposure.
Testing therapeutic interventions against pollutant-induced inflammation.
Mechanisms of toxocant-induced craniofacial birth defects
Mechanisms by which air pollutants enhance susceptibility to and the severity of respiratory virus infections
Computational modeling of DNA repair and checkpoint pathways; systems of protection of genetic stability
Gene-environment Interactions in Airway Diseases
Genetic determinants of environmental lung diseases
Cardiovascular disease and susceptibility, air pollutants, cardiopulmonary interactions, molecular mechanisms, genetic and environmental factors
The use of in vitro cell-based hepatic culture models to investigate mechanisms of compound-induced hepatotoxicity.
Understanding the underlying mechanisms responsible for modulation of normal immune function by environmental agents and the development of alternative testing methods for screening/testing immunotoxicants.
Metabolomics, tissue engineering and systems biology
Mechanisms of ambient air pollutant-induced cardiopulmonary morbidity and mortality
Genetics and molecular pathology of obesity, diabetes, hypercholesterolemia, insulin resistance, and hypertension
Environmental and public health epigenetics, translational research, molecular and mechanistic toxicology, advanced in vitro models
Neurotoxicology and excitotoxicity of alcohol
Endocrinology of pregnancy and parturition and reproductive and developmental toxicity
Pharmacogenetics of detoxification pathways in skin and inhalation exposures to toxicants; mathematical and statistical exposure modeling for risk assessment
Translational and clinical research in environmental lung disease
Use of animal models to mimic findings of biological diversity in human cancers; develop predictive computational models to test new therapeutics specific for tumor subtypes
Polygenic basis of complex traits and gene-environment interactions
Neurotoxicological effects of environmental pollutants, cellular stress pathways
Mechanisms of chromosome strand break repair
Airway epithelial cell biology, pulmonary innate immunity and transplant pathophysiology
Cell and molecular mechanisms of inflammatory responses induced by inhalation of ambient air pollutants
Biochemical mechanisms of nucleotide excision repair, DNA damage cell cycle checkpoints, and circadian rhythm
Mechanisms of stem cell senescence; genetics of the INK4/ARF tumor suppressor locus in melanoma; melanoma therapeutics
Metabolic interactions of essential microelements, especially trace metals, with toxic metals and metalloids that contaminate food and drinking water
Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin
Molecular carcinogenesis, environmental toxicology, molecular epidemiology of melanomas, research translation, biomarkers
Biomolecular informatics; molecular structure-function modeling using statistical and machine learning approaches
Control mechanisms of DNA replication during normal passage through an unperturbed cell cycle and in response to DNA-damaging agents
Mechanistic toxicology, hepatic toxicology, research translation, biomarkers
Chromatin remodeling and epigenetic alterations in human cancers
Basic reproductive biology of early mammalian embryogenesis, epigenetics, and how the environment impacts reproduction.
Mechanisms of androgen receptor (AR) regulation of gene transcription and cell proliferation in the human male and female reproductive tracts