Channing Der

The role of the ras oncogne, ras-mediated signalling and ras-related small GTPases in cancer and development of anti-ras inhibitors

Institution:  University of North Carolina School of Medicine

Website:  http://www.med.unc.edu/pharm/people/primaryfaculty/channing-der-1

Email:  cjder@med.unc.edu

Voice:  (919) 966-5634

Publications

Our research centers on understanding the molecular basis of human carcinogenesis. In particular, a major focus of our studies is the Ras oncogene and Ras-mediated signal transduction. The goals of our studies include the delineation of the complex components of Ras signaling and the development of anti-Ras inhibitors for cancer treatment. Another major focus of our studies involves our validation of the involvement of Ras-related small GTPases (e.g., Ral, Rho) in cancer. We utilize a broad spectrum of technical approaches that include cell culture and mouse models, C. elegans, protein crystallography, microarray gene expression or proteomics analyses, and clinical trial analyses.