Faculty research interests include most areas of toxicology, with particular emphasis on understanding the links between the environment and health risks, the mode of action of toxicants and disease pathogenesis, and how emerging knowledge could be translated into prevention strategies, new therapeutic interventions and an improved scientific basis for risk assessment. These interests reflect traditional disease- and/or organ-centric research areas in toxicology and the existing strengths of our current faculty. The main research areas include:
| Name |
Research Interest |
| Allen, James W., PhD |
Genetic and epigenetic mechanisms in environmental carcinogenesis; chemical-induced alterations in DNA methylation, gene expression, and chromosomal damage; life-stage and nutritional susceptibility risk factors that modulate toxic/carcinogenic effects of chemicals |
| Archer, Trevor, PhD |
Molecular carcinogenesis, chromatin structure, control of gene transcription, epigenetics |
| Ball, Louise M., PhD |
Metabolism and genotoxicity of environmental xenobiotics; DNA binding of polycyclic aromatic hydrocarbons and nitrosubstituted arenes, and of water disinfection products |
| Cannon, Ronald E., PhD |
Cancer biology, transgenic mouse models |
| Carey, Lisa A., MD |
Breast carcinogenesis, research translation, animal models of human diseases, biomarkers |
| Chaney, Stephen G., PhD |
Platinum anticancer agents, DNA repair, mutagenesis, translation DNA polymerases, molecular modeling |
| Church, Frank C., PhD |
Breast and prostate carcinogenesis, macromolecular structure-function, molecular pathology |
| Coleman, William B., PhD |
Biology of liver stem-like cells; hepatocarcinogenesis; genetic and epigenetic mechanisms of breast cancer susceptibility; molecular genetics of lung cancer |
| Cordeiro-Stone, Marila, PhD |
DNA replication, DNA repair, and cell cycle checkpoints in human cells; mechanisms of carcinogenesis by solar radiation; pathogenesis of melanoma |
| Der, Channing J., PhD |
Molecular basis of human carcinogenesis; Ras oncogene signaling and the development of anti-Ras inhibitors for cancer treatment |
| Gammon, Marilie D., PhD |
Cancer epidemiology |
| Hayes, D. Neil, MD |
Lung carcinogenesis, research translation, biomarkers, computational toxicology |
| Kaufman, David G., MD, PhD |
Targets for carcinogenesis among DNA regions replicated in early S phase; identification of replication origins; reconstruction of human endometrial tissue to study cancer development |
| Kaufmann, William K., PhD |
DNA Metabolism in Radiation and Chemical Carcinogenesis |
| Magnuson, Terry, PhD |
Novel approaches to allelic series of genomic modifications in mammals; polycomb-group complexes and development; Swi/Snf chromatin remodeling complexes |
| Millikan, Robert C., DVM, PhD |
Role of genetics in human cancer; interactions of inherited variation in DNA repair with environmental factors in breast and colon cancer and malignant melanoma; carcinogen metabolism |
| Olshan, Andrew F., PhD |
Molecular epidemiology of cancer, reproductive, and developmental outcomes |
| Rathmell, W. Kimryn, MD, PhD |
Genetics of renal cell carcinoma |
| Sancar, Aziz, MD, PhD |
DNA repair and cancer, structure and function of repair enzymes and checkpoint proteins |
| Swenberg, James A., DVM, PhD |
Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin |
| Thomas, Nancy E., MD, PhD |
Molecular carcinogenesis, environmental toxicology, molecular epidemiology of melanomas, research translation, biomarkers |
| Threadgill, David W., PhD |
Research using the mouse as a model to study genetic and environmental factors that underline differences in cancer susceptibility |
| Van Dyke, Terry A., PhD |
Geneticaly engineered mice, cancer models, roles of p53, pRb, and PTEN |
| Walker, Nigel, PhD |
Environmental contaminants and mechanisms of carcinogenesis |
| Weissman, Bernard E., PhD |
Chromatin remodeling and epigenetic alterations in human cancers |
| Zeisel, Steven H., MD, PhD |
Choline and carcinogenesis, isoflavones and cancer, antioxidants and apoptosis |
| Name |
Research Interest |
| Allen, James W., PhD |
Genetic and epigenetic mechanisms in environmental carcinogenesis; chemical-induced alterations in DNA methylation, gene expression, and chromosomal damage; life-stage and nutritional susceptibility risk factors |
| Anderson, Melvin E., PhD |
Computational modeling of signal transduction pathways and their perturbations by xenobiotics; implications for dose-response and risk assessment |
| Birnbaum, Linda S., PhD |
Chemical disposition of xenobiotics and mechanistic toxicology |
| Brouwer, Kim R., PhD |
Pharmacokinetics, hepatic uptake, metabolism and excretion of xenobiotics |
| Cordeiro-Stone, Marila, PhD |
DNA replication, DNA repair, and cell cycle checkpoints in human cells; mechanisms of carcinogenesis by solar radiation; pathogenesis of melanoma |
| DeVito, Michael, PhD |
Development of models for cumulative risk to endocrine disruptors |
| Gold, Avram, PhD |
Structure-reactivity relationships in metabolism and mutagenicity of polycyclic aromatic hydrocarbons |
| Graves, Lee M., PhD |
Biochemistry of growth factor-mediated signal transduction |
| Hunter, E. Sidney, PhD |
Role of cell death in in and mechanisms responsible for craniofacial birth defects. Use of embryonic stem cells as a model to evaluate developmental effects of environmental chemicals |
| Kaufmann, William K., PhD |
Mechanisms of DNA repair and checkpoint responses to DNA damage |
| Kleeberger, Steven R., PhD |
Genetic determinants of environmental lung diseases |
| MacDonald, Jeffery M., PhD |
Metabolomics and fluxomics using NMR spectroscopy and imaging; tissue engineering |
| Madden, Michael C., PhD |
Air pollution toxicology, lung oxidative stress and inflammation, translational medicine |
| Maeda, Noyubo, PhD |
Animal models of hyperlipidemia, atherosclerosis and cardiomyopathy, transgenic laboratory animals as model systems |
| Nylander-French, Leena A., PhD |
Develop methods to monitor and assess dermal and inhalation exposures to environmental toxicants |
| Ramsden, Dale A., PhD |
V(D)J recombination and DNA double strand break repair |
| Randell, Scott H., PhD |
Identification of airway epithelial stem cells; airway innate immunity; pathophysiology of post-lung transplant ischemia reperfusion injury and bronchiolitis obliterans syndrome |
| Rogers, John M., PhD |
Developmental toxicology, teratology, developmental biology, embryology and nutrition |
| Rusyn, Ivan I., MD, PhD |
Environmental Genomics |
| Samet, James M., PhD |
Inflammatory responses to pollution inhalation, cytokines and eicosanoids |
| Samulski, R. Jude, PhD |
Development of efficient viral vectors for gene delivery into eukaryotic cells |
| Sharpless, Norman E., MD |
Tumor suppressor genes; genetics of cancer and aging |
| Sills, Robert C., DVM, PhD |
Molecular Pathology |
| Smith, Philip C., PhD |
Toxicokinetics and xenobiotic metabolism, peptide analysis and disposition |
| Styblo, Miroslav, PhD |
Metabolism and toxicity of metals and metalloids |
| Swenberg, James A., DVM, PhD |
Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin |
| Watkins, Paul B., MD |
Mechanistic toxicology, hepatotoxicology, research translation, biomarkers |
| Wilson, Elizabeth M., PhD |
Mechanistic toxicology, hepatotoxicology, research translation, biomarkers |
| Wolf, Douglas C., DVM, PhD |
Chemical Carcinogenesis |
| Name |
Research Interest |
| Church, Frank C., PhD |
Thrombosis and hemostasis; macromolecular structure-function, molecular pathology |
| Costa, Daniel L., ScD |
Cardiopulmonary and inhalation toxicology, health effects of air pollution |
| Devlin, Robert D., PhD |
Pulmonary toxicology and molecular biology |
| Diaz-Sanchez, David, Ph.D. |
Environmental impacts on human health, genetic susceptibility, immunology, epigenetics, translational research |
| Gilmour, M. Ian, PhD |
Pulmonary toxicology, immunotoxicology |
| Graves, Lee M., PhD |
Biochemistry of growth factor-mediated signal transduction |
| Hazucha, Milan J., MD, PhD |
Health effects of air pollutants, human studies and mechanisms of response |
| Jaspers, Ilona, PhD |
Effects of environmental pollutants on airway epithelium and susceptibility to viral infections. |
| Kleeberger, Steven R., PhD |
Genetic determinants of environmental lung diseases |
| Madden, Michael C., PhD |
Air pollution toxicology, lung oxidative stress and inflammation, translational medicine |
| Maeda, Noyubo, PhD |
Animal models of hyperlipidemia, atherosclerosis and cardiomyopathy, transgenic laboratory animals as model systems |
| Patterson, W. Campbell, MD |
Vascular biology, angiogenesis, and protein folding and degradation |
| Peden, David B., MD |
Translational and clinical research in environmental lung disease |
| Roth, Bryan L., MD, PhD |
Cardiopulmonary toxicology, research translation, animal models of human diseases, biomarkers |
| Runge, Marschall S., MD, PhD |
Cardiopulmonary toxicology, vascular biology, thrombosis and atherosclerosis, role of reactive oxygen species |
| Samet, James M., PhD |
Inflammatory responses to pollution inhalation, cytokines and eicosanoids |
| Name |
Research Interest |
| Crews, Fulton T., PhD |
Neurodegeneration and chronic drug-induced changes in brain signaling pathways |
| Crofton, Kevin M., PhD |
Understanding the consequences of endocrine disruption on neurodevelopment |
| Deshmukh, Monhanish P., PhD |
Mechanisms of neuronal programmed cell death |
| Harry, G. Jean, PhD |
Developmental neurotoxicology, molecular neurotoxicology and neuroimmunology |
| Maness, Patricia F., PhD |
Axon guidance and signal transduction in nervous system development |
| Morrow, A. Leslie, PhD |
Neurotoxicology and excitotoxicity of alcohol |
| Padilla, Stephanie, PhD |
Neurotoxicology, developmental neurotoxicity, zebrafish, anticholinesterase pesticide toxicity |
| Pomp, Daniel, PhD |
Genetic architecture of complex traits; polygenic mouse models and high throughput approaches to study obesity and related diseases; gene-environment interactions in carcinogenesis |
| Zeisel, Steven H., MD, PhD |
Nutrients and brain development |
| Name |
Research Interest |
| Brouwer, Kim R., PhD |
Pharmacokinetics, hepatic transport, hepatobiliary disposition, metabolism and excretion of xenobiotics, hepatotoxicity |
| Cidlowski, John A., PhD |
Apoptosis, steroids, glucocorticoid receptors, hormone action, nucleases and gene regulation |
| Coleman, Rosalind A., MD |
Diabetes: lipid and carbohydrate metabolism; obesity: partition of energy between triacylglycerol storage and fatty acid oxidation; regulation of triacylglycerol synthesis; glycogen storage disease |
| Pollack, Gary M., PhD |
Pharmacokinetics and pharmacodynamics of therapeutic and toxic agents |
| Rusyn, Ivan I., MD, PhD |
Environmental Genomics |
| Smith, Philip C., PhD |
Toxicokinetics and xenobiotic metabolism, peptide analysis and disposition |
| Swenberg, James A., DVM, PhD |
Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin |
| Threadgill, David W., PhD |
Research using the mouse as a model to study phenotypes with complex etiologies contributed by genetic and environmental factors that underline differences in susceptibility to common diseases |
| Watkins, Paul B., MD |
Mechanistic toxicology, hepatotoxicology, research translation, biomarkers |
| Name |
Research Interest |
| Anderson, Melvin E., PhD |
Computational modeling of signal transduction pathways and their perturbations by xenobiotics; implications for dose-response and risk assessment |
| Chaney, Stephen G., PhD |
Platinum anticancer agents, DNA repair, mutagenesis, translation DNA polymerases, molecular modeling |
| DeVito, Michael, PhD |
Development of models for cumulative risk to endocrine disruptors |
| Hayes, D. Neil, MD |
Molecular carcinogenesis, research translation, biomarkers, computational toxicology |
| Kaufmann, William K., PhD |
Computational modeling of DNA repair and checkpoint pathways; systems of protection of genetic stability |
| Perou, Charles M., PhD |
Use of animal models to mimic findings of biological diversity in human cancers; develop predictive computational models to test new therapeutics specific for tumor subtypes |
| Pomp, Daniel, PhD |
Genetic architecture of complex traits; polygenic mouse models and high throughput approaches to study obesity and related diseases; gene-environment interactions in carcinogenesis |
| Rusyn, Ivan I., MD, PhD |
Environmental Genomics |
| Threadgill, David W., PhD |
Research using the mouse as a model to study phenotypes with complex etiologies contributed by genetic and environmental factors that underline differences in susceptibility to common diseases |
| Tropsha, Alexander, PhD |
Molecular modeling, computer-assisted drug design, molecular dynamics of proteins, protein folding |
| Name |
Research Interest |
| Birnbaum, Linda S., PhD |
Chemical disposition of xenobiotics and mechanistic toxicology |
| Fenton, Suzanne E., PhD |
Environmental effects on mammary gland development and function |
| Gilmour, M. Ian, PhD |
Pulmonary toxicology, immunotoxicology |
| Graves, Lee M., PhD |
Biochemistry of growth factor-mediated signal transduction |
| Harry, G. Jean, PhD |
Developmental neurotoxicology, molecular neurotoxicology and neuroimmunology |
| Hunter, E. Sidney, PhD |
Role of cell death in mechanisms responsible for craniofacial birth defects. Use of embryonic stem cells as a model to evaluate developmental effects of environmental chemicals |
| Jaspers, Ilona, PhD |
Effects of environmental pollutants on airway epithelium and susceptibility to viral infections. |
| Narotsky, Michael G., Ph.D. |
Developmental toxicology, reproductive toxicology, pregnancy maintenance, and parturition |
| Nylander-French, Leena A., PhD |
Develop methods to monitor and assess dermal and inhalation exposures to environmental toxicants |
| Olshan, Andrew F., PhD |
Molecular epidemiology of cancer, reproductive, and developmental outcomes |
| Rogers, John M., PhD |
Developmental toxicology, teratology, developmental biology, embryology and nutrition |
| Roubey, Robert A. S.., MD |
Developmental and immunotoxicology, animal models of human diseases, biomarkers
|
| Selgrade, MaryJane K., PhD |
Immunotoxicology |
| Sulik, Kathleen K., PhD |
Birth defects, neuroteratology, fetal alcohol spectrum disorders(FASD), high resolution magnetic imaging (MRI) |
| Name |
Research Interest |
| Brouwer, Kim R., PhD |
Pharmacokinetics, hepatic uptake, metabolism and excretion of xenobiotics |
| MacDonald, Jeffery M., PhD |
Metabolomics and fluxomics using NMR spectroscopy and imaging |
| Mason, Ronald P., PhD |
Free-radical intermediates in the metabolism of toxic chemicals |
| Paine, Mary, Ph.D., R.Ph. |
Drug xenobiotic metabolism, pharmacokinetics, drug xenobiotic interactions |
| Pollack, Gary M., PhD |
Pharmacokinetics and pharmacodynamics of therapeutic and toxic agents |
| Smith, Philip C., PhD |
Toxicokinetics and xenobiotic metabolism, peptide analysis and disposition |
| Tropsha, Alexander, PhD |
Molecular modeling, computer-assisted drug design, molecular dynamics of proteins, protein folding |