Faculty research interests include most areas of toxicology, with particular emphasis on understanding the links between the environment and health risks, the mode of action of toxicants and disease pathogenesis, and how emerging knowledge could be translated into prevention strategies, new therapeutic interventions and an improved scientific basis for risk assessment. These interests reflect traditional disease- and/or organ-centric research areas in toxicology and the existing strengths of our current faculty. The main research areas include:
| Name |
Research Interest |
| Allen, James W., PhD |
Genetic and epigenetic mechanisms in environmental carcinogenesis; chemical-induced alterations in DNA methylation, gene expression, and chromosomal damage; life-stage and nutritional susceptibility risk factors that modulate toxic/carcinogenic effects of chemicals |
| Archer, Trevor, PhD |
Molecular carcinogenesis, chromatin structure, control of gene transcription, epigenetics |
| Ball, Louise M., PhD |
Metabolism and genotoxicity of environmental xenobiotics; DNA binding of polycyclic aromatic hydrocarbons and nitrosubstituted arenes, and of water disinfection products |
| Carey, Lisa A., MD |
Breast carcinogenesis, research translation, animal models of human diseases, biomarkers |
| Chaney, Stephen G., PhD |
Platinum anticancer agents, DNA repair, mutagenesis, translation DNA polymerases, molecular modeling |
| Church, Frank C., PhD |
Breast and prostate carcinogenesis, macromolecular structure-function, molecular pathology |
| Coleman, William B., PhD |
Biology of liver stem-like cells; hepatocarcinogenesis; genetic and epigenetic mechanisms of breast cancer susceptibility; molecular genetics of lung cancer |
| Cordeiro-Stone, Marila, PhD |
DNA replication, DNA repair, and cell cycle checkpoints in human cells; mechanisms of carcinogenesis by solar radiation; pathogenesis of melanoma |
| Der, Channing J., PhD |
Molecular basis of human carcinogenesis; Ras oncogene signaling and the development of anti-Ras inhibitors for cancer treatment |
| Gammon, Marilie D., PhD |
Cancer epidemiology |
| Hayes, D. Neil, MD |
Lung carcinogenesis, research translation, biomarkers, computational toxicology |
| Kaufman, David G., MD, PhD |
Targets for carcinogenesis among DNA regions replicated in early S phase; identification of replication origins; reconstruction of human endometrial tissue to study cancer development |
| Kaufmann, William K., PhD |
DNA Metabolism in Radiation and Chemical Carcinogenesis |
| Millikan, Robert C., DVM, PhD |
Role of genetics in human cancer; interactions of inherited variation in DNA repair with environmental factors in breast and colon cancer and malignant melanoma; carcinogen metabolism |
| Olshan, Andrew F., PhD |
Molecular epidemiology of cancer, reproductive, and developmental outcomes |
| Rathmell, W. Kimryn, MD, PhD |
Genetics of renal cell carcinoma |
| Swenberg, James A., DVM, PhD |
Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin |
| Thomas, Nancy E., MD, PhD |
Molecular carcinogenesis, environmental toxicology, molecular epidemiology of melanomas, research translation, biomarkers |
| Weissman, Bernard E., PhD |
Chromatin remodeling and epigenetic alterations in human cancers |
| Name |
Research Interest |
| Allen, James W., PhD |
Genetic and epigenetic mechanisms in environmental carcinogenesis; chemical-induced alterations in DNA methylation, gene expression, and chromosomal damage; life-stage and nutritional susceptibility risk factors |
| Anderson, Melvin E., PhD |
Computational modeling of signal transduction pathways and their perturbations by xenobiotics; implications for dose-response and risk assessment |
| Brouwer, Kim R., PhD |
Pharmacokinetics, hepatic uptake, metabolism and excretion of xenobiotics |
| Cordeiro-Stone, Marila, PhD |
DNA replication, DNA repair, and cell cycle checkpoints in human cells; mechanisms of carcinogenesis by solar radiation; pathogenesis of melanoma |
| DeVito, Michael, PhD |
Development of models for cumulative risk to endocrine disruptors |
| Graves, Lee M., PhD |
Biochemistry of growth factor-mediated signal transduction |
| Hunter, E. Sidney, PhD |
Role of cell death in and mechanisms responsible for craniofacial birth defects. Use of embryonic stem cells as a model to evaluate developmental effects of environmental chemicals |
| Kaufmann, William K., PhD |
Mechanisms of DNA repair and checkpoint responses to DNA damage |
| Kleeberger, Steven R., PhD |
Genetic determinants of environmental lung diseases |
| MacDonald, Jeffery M., PhD |
Metabolomics and fluxomics using NMR spectroscopy and imaging; tissue engineering |
| Madden, Michael C., PhD |
Air pollution toxicology, lung oxidative stress and inflammation, translational medicine |
| Maeda, Noyubo, PhD |
Animal models of hyperlipidemia, atherosclerosis and cardiomyopathy, transgenic laboratory animals as model systems |
| Rusyn, Ivan I., MD, PhD |
Environmental Genomics |
| Samet, James M., PhD |
Inflammatory responses to pollution inhalation, cytokines and eicosanoids |
| Samulski, R. Jude, PhD |
Development of efficient viral vectors for gene delivery into eukaryotic cells |
| Smith, Philip C., PhD |
Toxicokinetics and xenobiotic metabolism, peptide analysis and disposition |
| Swenberg, James A., DVM, PhD |
Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin |
| Wolf, Douglas C., DVM, PhD |
Chemical Carcinogenesis |
| Name |
Research Interest |
| Church, Frank C., PhD |
Thrombosis and hemostasis; macromolecular structure-function, molecular pathology |
| Costa, Daniel L., ScD |
Cardiopulmonary and inhalation toxicology, health effects of air pollution |
| Devlin, Robert D., PhD |
Pulmonary toxicology and molecular biology |
| Diaz-Sanchez, David, Ph.D. |
Environmental impacts on human health, genetic susceptibility, immunology, epigenetics, translational research |
| Gilmour, M. Ian, PhD |
Pulmonary toxicology, immunotoxicology |
| Graves, Lee M., PhD |
Biochemistry of growth factor-mediated signal transduction |
| Hazucha, Milan J., MD, PhD |
Health effects of air pollutants, human studies and mechanisms of response |
| Jaspers, Ilona, PhD |
Effects of environmental pollutants on airway epithelium and susceptibility to viral infections. |
| Kleeberger, Steven R., PhD |
Genetic determinants of environmental lung diseases |
| Kodavanti, Urmila P., Ph.D., DABT |
Cardiovascular disease and susceptibility, air pollutants, cardiopulmonary interactions, molecular mechanisms, genetic and environmental factors |
| Madden, Michael C., PhD |
Air pollution toxicology, lung oxidative stress and inflammation, translational medicine |
| Maeda, Noyubo, PhD |
Animal models of hyperlipidemia, atherosclerosis and cardiomyopathy, transgenic laboratory animals as model systems |
| Patterson, W. Campbell, MD |
Vascular biology, angiogenesis, and protein folding and degradation |
| Peden, David B., MD |
Translational and clinical research in environmental lung disease |
| Roth, Bryan L., MD, PhD |
Cardiopulmonary toxicology, research translation, animal models of human diseases, biomarkers |
| Runge, Marschall S., MD, PhD |
Cardiopulmonary toxicology, vascular biology, thrombosis and atherosclerosis, role of reactive oxygen species |
| Samet, James M., PhD |
Inflammatory responses to pollution inhalation, cytokines and eicosanoids |
| Name |
Research Interest |
| Anderson, Melvin E., PhD |
Computational modeling of signal transduction pathways and their perturbations by xenobiotics; implications for dose-response and risk assessment |
| Chaney, Stephen G., PhD |
Platinum anticancer agents, DNA repair, mutagenesis, translation DNA polymerases, molecular modeling |
| DeVito, Michael, PhD |
Development of models for cumulative risk to endocrine disruptors |
| Hayes, D. Neil, MD |
Molecular carcinogenesis, research translation, biomarkers, computational toxicology |
| Kaufmann, William K., PhD |
Computational modeling of DNA repair and checkpoint pathways; systems of protection of genetic stability |
| Perou, Charles M., PhD |
Use of animal models to mimic findings of biological diversity in human cancers; develop predictive computational models to test new therapeutics specific for tumor subtypes |
| Rusyn, Ivan I., MD, PhD |
Environmental Genomics |
| Tropsha, Alexander, PhD |
Molecular modeling, computer-assisted drug design, molecular dynamics of proteins, protein folding |
| Name |
Research Interest |
| Gilmour, M. Ian, PhD |
Pulmonary toxicology, immunotoxicology |
| Graves, Lee M., PhD |
Biochemistry of growth factor-mediated signal transduction |
| Hunter, E. Sidney, PhD |
Role of cell death in mechanisms responsible for craniofacial birth defects. Use of embryonic stem cells as a model to evaluate developmental effects of environmental chemicals |
| Jaspers, Ilona, PhD |
Effects of environmental pollutants on airway epithelium and susceptibility to viral infections. |
| Narotsky, Michael G., Ph.D. |
Developmental toxicology, reproductive toxicology, pregnancy maintenance, and parturition |
| Olshan, Andrew F., PhD |
Molecular epidemiology of cancer, reproductive, and developmental outcomes |
| Roubey, Robert A. S.., MD |
Developmental and immunotoxicology, animal models of human diseases, biomarkers
|
| Selgrade, MaryJane K., PhD |
Immunotoxicology |
| Sulik, Kathleen K., PhD |
Birth defects, neuroteratology, fetal alcohol spectrum disorders(FASD), high resolution magnetic imaging (MRI) |
| Name |
Research Interest |
| Brouwer, Kim R., PhD |
Pharmacokinetics, hepatic uptake, metabolism and excretion of xenobiotics |
| MacDonald, Jeffery M., PhD |
Metabolomics and fluxomics using NMR spectroscopy and imaging |
| Mason, Ronald P., PhD |
Free-radical intermediates in the metabolism of toxic chemicals |
| Paine, Mary, Ph.D., R.Ph. |
Drug xenobiotic metabolism, pharmacokinetics, drug xenobiotic interactions |
| Pollack, Gary M., PhD |
Pharmacokinetics and pharmacodynamics of therapeutic and toxic agents |
| Smith, Philip C., PhD |
Toxicokinetics and xenobiotic metabolism, peptide analysis and disposition |
| Tropsha, Alexander, PhD |
Molecular modeling, computer-assisted drug design, molecular dynamics of proteins, protein folding |