Samira Brooks

Graduate Student

Contact Information

  • Email:  sabrooks@email.unc.edu
  • Office:  (919) 843-6078
  • Location:  21-237 Lineberger Comprehensive Cancer Center
Samira Brooks

Education

  • B.S., Biology, Bowie State University
  • Joined the Biological and Biomedical Sciences Program in 2010
  • Adviser:  Kim Rathmell

Research Interests

The majority of patients with renal tumors have the clear cell RCC (ccRCC) subtype, a tumor associated with VHL mutations and a poor prognosis in the metastatic state. Recently, the lab elucidated two subtypes of clear cell RCC, ccA and ccB, that convey a prognostic value, with tumors displaying the ccA signature associated with an 8.6 year survival as compared to only 2 years for ccB. Originally, 120 genes were identified to assign ccA and ccB classification to ccRCC tumors, but we have now condensed this list into only ten genes. The ccA/ccB definitive biomarker set is undergoing validation and development as a diagnostic test. Classifying a large cohort of retrospectively collected non-metastatic ccRCC specimens and identifying correlations between the subtypes and risk assessments, including disease recurrence and cancer-specific survival, will accomplish this. Once the biomarkers are authenticated, we plan to further investigate if ccRCC subclassification can predict clinical response to anti-angiogenic therapies. These results will all be used as preliminary data to develop a biomarker inclusive risk algorithm for integration into the clinical arena.

Personal Interests

Music, reading