Robin Muller

Graduate Student

Medicine

Contact Information

Robin Muller

Education

  • B.S., Biochemistry, University of North Carolina at Chapel Hill
  • Joined the Biological and Biomedical Sciences Program in 2011
  • Adviser:  David Peden

Research Interests

I am studying the effect of acute wood smoke exposure on the innate immune system. Danger signals are produced by the body's cells after injury. These danger-associated molecular patterns, or DAMPs, include molecules like double-stranded DNA, ATP, adenosine, uric acid and hyaluronic acid. On release, DAMPs are detected by Toll-like receptors (TLRs) on immune cell membrane. Recent research has shown that TLR activation leads to a robust inflammatory response via recruitment of the inflammasome. This DAMP-TLR-inflammasome pathway may be responsible for the acute respiratory distress syndrome seen in burn patients after smoke exposure. For my project, I plan to show that wood smoke exposure leads to DAMP release in mice. Further, I would like to demonstrate that intratracheal instillation of DAMPs results in local and systemic inflammation. I am accompanying these in vivo experiments with in vitro experiments in human macrophages in order to uncover the mechanism through which DAMPs mediate inflammation.

Personal Interests

Medicine

 

Medicine