Animal Models of Human Disease
The mouse has become the gold standard model for molecular research in the post-genome era. In support of broadening the utility of the mouse as an experimental model for all facets of biology, a multinational effort is underway to develop a comprehensive comparative phenotypic database on inbred strains representing a broad genetic diversity.
The training opportunities in this area combine expertise of mouse geneticists, toxicologists, experimental biologists and clinicians and capitalize on a broad spectrum of animal models from novel knockouts and transgenics, to genetic models of disease, to inbred and recombinant inbred strains. The environmental health-related research questions that are being pursued by the Toxicology faculty range from cancer biology, to nutrition-environment interactions, to genetic susceptibility of chemical-induced toxicity and carcinogenesis. Animal facilities and veterinary staff, availability of strains and genotyping services, existing projects and collaborations among multiple faculty, opportunities for translational research, as well as extensive computational toxicology expertise are unparalleled and attract numerous incoming pre- and post-doctoral trainees.
- Curriculum Members
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Carey, Lisa A., MD
Coleman, Rosalind A., MD
Coleman, William B., PhD
Crofton, Kevin M., PhD
Deshmukh, Monhanish P., PhD
Harry, G. Jean, PhD
Kleeberger, Steven R., PhD
Luebke, Robert W., PhD
Maeda, Noyubo, PhD
Magnuson, Terry, PhD
Narotsky, Michael G., PhD
Padilla, Stephanie, PhD
Pomp, Daniel, PhD
Randell, Scott H., PhD
Rathmell, W. Kimryn, MD, PhD
Roth, Bryan L., MD, PhD
Roubey, Robert A. S.., MD
Rusyn, Ivan I., MD, PhD
Selgrade, MaryJane, PhD
Sharpless, Norman E., MD
Smith, Philip C., PhD
Threadgill, David W., PhD
Tropsha, Alexander, PhD
Tyl, Rochelle, PhD
Van Dyke, Terry A., PhD
Weissman, Bernard E., PhD
