Website:
Email: carraway.martha@epamail.epa.gov
Voice:
]]>Website: http://www.med.unc.edu/pharm/people/joint-faculty/frank-church-1/frank-church
Email: fchurch@email.unc.edu
Voice: (919) 966-3311
Our research is concerned with proteases and their inhibitors in various disease processes (thrombosis and cancer); our science tools are structure-activity, cell biology and signaling, pathobiology, immunohistochemistry, and in vivo models.
]]>Email: fesslerm@niehs.nih.gov
Voice: (919) 541-3701
The Fessler laboratory investigates mechanisms of induction and regulation of the innate immune response, with a focus on Toll like Receptors (TLRs). Approaches used include studies of TLR signal transduction (biochemistry, molecular biology) in cultured macrophages; in vivo models of lung injury, pneumonia, and sepsis in mice; and translational studies involving human peripheral blood leukocytes.
]]>Email: Farraj.aimen@Epa.gov
]]>Email: costa.dan@epa.gov
Voice: (919) 541-2532
Dr Costa's primary research interests focus on the potential for air pollutants to adversely affect human health. By using animal models representing healthy and susceptible human populations (chronic heart and lung diseases), he has made major in-roads into understanding how contaminants in the air can cause illness and even death. He uses methods in cardiopulmonary and neurophysiology coupled with modern cell-molecular biology to develop these models and to ascertain how health impairments influence responsiveness to pollutant stresses.
]]>Email: devlin.robert@epa.gov
Voice: (919) 966-6256
]]>Email: diaz-sanchez.david@epa.gov
Voice:
The work focuses on how air pollutants affect human health, the role of genetics and epigenetic factors in determining susceptibility and clinical/dietary strategies to mitigate these effects. There is a strong emphasis on translational research projects using a multi-disciplinary approach. Thus, by using human in vivo models (such as clinical studies) we validate in vitro, epidemiology, and animal findings.
]]>Website:
Email: dreher.kevin@epa.gov
Voice:
Publications: pubmed
]]>Email: gilmour.ian@epa.gov
Voice: (919) 541-0015
Dr. M Ian Gilmour is a Principal Investigator at the National Health and Environmental Effects Research Laboratory (NHEERL), U.S Environmental Protection Agency in RTP. He received an Honors degree in microbiology from the University of Glasgow, and a doctorate in aerosol science and mucosal immunology from the University of Bristol in 1988. After post-doctoral work at the John Hopkins School of Public Health and the U.S. EPA, he became a Research Associate in the Center for Environmental Medicine at the University of North Carolina. In 1998 he joined the EPA fellowship program and in 2000 became a permanent staff member. He holds adjunct faculty positions with the UNC School of Public Health and the Curriculum in Toxicology, and at NC State Veterinary School. He has published over 80 research articles in the field of pulmonary immunobiology where his research focuses on the interaction between air pollutant exposure and the development of infectious and allergic lung disease.
]]>Email: hazari.mehdi@epa.gov
Voice:
Neurophysiological mechanisms mediating cardiopulmonary dysfunction due to air pollution exposure.
]]>Website:
Email: michelle_hernandez@med.unc.edu
Voice:
]]>Email: ilona_jaspers@med.unc.edu
Voice: (919) 966-8657
Research in my lab focuses on the mechanisms by which exposure to air pollutants can enhance the susceptibility to and the severity of respiratory virus infections. Specifically, we are examining the effects of air pollutants such as diesel exhaust and cigarette smoke on influenza virus infections, using several in vitro models of the respiratory epithelium. In collaboration with physicians from the Department of Pediatrics, we are also translating these studies into humans in vivo.
]]>Website: http://www.niehs.nih.gov/research/atniehs/labs/lrb/enviro-gen/index.cfm
Email: kleeber1@niehs.nih.gov
Voice: (919) 541-3540
Genetic determinants of environmental lung diseases.
]]>Email: kodavanti.urmila@epa.gov
Voice: (919) 541-4963
]]>Website:
Email: madden.michael@epa.gov
Voice: (919) 966-6257
Research description: Exposure to ambient air particulate matter(PM) has been associated with increased human deaths and cardiopulmonary morbidity, such as lung infections and increased asthma symptoms. I am investigating some types of PM and associated gases (such as aldehydes) that may be associated with those health effects so that the US EPA may be able to better regulate or manage the sources of the PM that are identified as playing a role in the adverse health outcomes. I am currently focusing on the effects of diesel exhaust using a variety of approaches ranging from exposing cultured human cells to the exhaust, to studying responses of humans exposed out in traffic. The EPA rules for diesel exhaust from large trucks implemented in 2007 and 2010 will drastically change the type of emissions, and I am currently designing and implementing testing strategies to assess the toxicity of the future types of diesel emissions. Additionally some of my research effort attempts to identify what populations are more sensitive to the effects of air pollutants, and the genetic and environmental reasons behind the increased sensitivity.
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