Email: fesslerm@niehs.nih.gov
Voice: (919) 541-3701
The Fessler laboratory investigates mechanisms of induction and regulation of the innate immune response, with a focus on Toll like Receptors (TLRs). Approaches used include studies of TLR signal transduction (biochemistry, molecular biology) in cultured macrophages; in vivo models of lung injury, pneumonia, and sepsis in mice; and translational studies involving human peripheral blood leukocytes.
]]>Email: diaz-sanchez.david@epa.gov
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The work focuses on how air pollutants affect human health, the role of genetics and epigenetic factors in determining susceptibility and clinical/dietary strategies to mitigate these effects. There is a strong emphasis on translational research projects using a multi-disciplinary approach. Thus, by using human in vivo models (such as clinical studies) we validate in vitro, epidemiology, and animal findings.
]]>Email: gilmour.ian@epa.gov
Voice: (919) 541-0015
Dr. M Ian Gilmour is a Principal Investigator at the National Health and Environmental Effects Research Laboratory (NHEERL), U.S Environmental Protection Agency in RTP. He received an Honors degree in microbiology from the University of Glasgow, and a doctorate in aerosol science and mucosal immunology from the University of Bristol in 1988. After post-doctoral work at the John Hopkins School of Public Health and the U.S. EPA, he became a Research Associate in the Center for Environmental Medicine at the University of North Carolina. In 1998 he joined the EPA fellowship program and in 2000 became a permanent staff member. He holds adjunct faculty positions with the UNC School of Public Health and the Curriculum in Toxicology, and at NC State Veterinary School. He has published over 80 research articles in the field of pulmonary immunobiology where his research focuses on the interaction between air pollutant exposure and the development of infectious and allergic lung disease.
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Email: michelle_hernandez@med.unc.edu
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]]>Email: ilona_jaspers@med.unc.edu
Voice: (919) 966-8657
Research in my lab focuses on the mechanisms by which exposure to air pollutants can enhance the susceptibility to and the severity of respiratory virus infections. Specifically, we are examining the effects of air pollutants such as diesel exhaust and cigarette smoke on influenza virus infections, using several in vitro models of the respiratory epithelium. In collaboration with physicians from the Department of Pediatrics, we are also translating these studies into humans in vivo.
]]>Email: luebke.robert@epa.gov
Voice: (919) 541-3672
Publications
]]>Email: peden@med.unc.edu
Voice: (919) 966-0768
Translational and clinical research in environmental lung disease.
]]>Website: http://www.med.unc.edu/cfpulmcenter/faculty/randell
Email: scott_randell@med.unc.edu
Voice: (919) 966-8093
Identification of airway epithelial stem cells; innate immunity in the airway; the pathophysiology of post-lung transplant ischemia reperfusion injury and bronchiolitis obliterans syndrome.
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