Website: http://pharmacy.unc.edu/research/labs/kim-brouwer-lab
Email: kbrouwer@unc.edu
Voice: (919) 962-7030
Research in the Brouwer laboratory is focused on: (1) hepatobiliary xenobiotic disposition, including mechanisms of hepatic uptake, translocation and biliary excretion; (2) development/refinement of in vitro model systems to predict in vivo hepatobiliary disposition, drug interactions, and hepatotoxicity; (3) hepatic drug transport; and (4) pharmacokinetics, including aberrant gastrointestinal drug absorption phenomena.
]]>Email: pwatkins@thehamner.org
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Email: ELeCluyse@thehamner.org
Voice:
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Email: jmacdona@med.unc.edu
Voice: (919) 843-5154
Dr. Macdonald is the Founder and Scientific Director of the new Metabolomic Facility and Co-Scientific Director of the joint UNC/NCSU/NOAA Marine MRI facility at Pivers Island near Beaufort NC. Dr. Macdonald's research goal is to combine metabolomics and tissue engineering and apply these tools to quantitative biosystem analysis.
]]>Website: http://www.med.unc.edu/alcohol/morrow.html
Email: morrow@med.unc.edu
Function, expression and trafficking GABA-A receptors in the CNS; effects of chronic ethanol exposure that leads to ethanol tolerance and dependence; role of endogenous neurosteroids on ethanol action and adaptations; etiology of essential tremor.
]]>Website: http://www.sph.unc.edu/?option=com_profiles&Itemid=1891&profileAction=ProfDetail&pid=704241888
Email: leena_frrench@unc.edu
Voice: (919) 966-3826
My research focuses on understanding the relationship between dermal and inhalation exposure and the effect of individual genetic differences on the function of enzymes that detoxify hazardous agents and that affect the development of disease. My research group has pioneered approaches to quantitatively measure skin and inhalation exposures to toxicants; additionally, my group has developed sophisticated exposure modeling tools using mathematical and statistical principles in an effort to standardize and improve exposure and risk assessment.
]]>Website: http://pharmacy.unc.edu/research/labs/mary-paine-lab
Email: mpaine@unc.edu
Voice: (919) 966-9984
The Paine group has two major research interests: (1) mechanisms underlying drug-xenobiotic interactions and (2) pharmacokinetic/toxicokinetic characterization of novel anti-parasitic agents.
]]>Website: http://www.sph.unc.edu/?option=com_profiles&profileAction=ProfDetail&pid=702665970
Email: iir@unc.edu
Voice: (919) 843-2596
Our laboratory applies molecular, biochemical, genetic and genomics approaches to understanding the mechanisms of environmental agent-related organ injury and carcinogenesis. Specifically, we are interested in nuclear receptor-mediated pathways in chemical carcinogenesis, oxidative DNA damage and repair, the role that alcohol and diet play in cancer, and the genetic determinants of the susceptibility to toxicant-induced liver injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.
]]>Website: http://www.sph.unc.edu/?option=com_profiles&Itemid=1900&profileAction=ProfDetail&pid=700156018
Email: styblo@med.unc.edu
Voice: (919) 966-5721
Research interests involve metabolic interactions of essential microelements, especially trace metals, with toxic metals and metalloids that contaminate food chain and drinking water reservoirs. Research topics include: the interactions between selenium, an essential micronutrient, and arsenic, an environmental contaminant and human carcinogen; the enzymes and co-factors involved in the metabolism of arsenic and selenium; the mechanisms of arsenic- induced diabetes; and, the role of nutritional antioxidants and antioxidant enzymes in responses to the oxidative stress induced by exposure to environmental toxins, by viral infections or nutritional deficiencies.
]]>Website: http://www.sph.unc.edu/?option=com_profiles&Itemid;=1891&profileAction;=ProfDetail&pid;=704283985
Email: james_swenberg@unc.edu
Voice: (919) 966-6139
My laboratory focuses on understanding mechanisms of carcinogenesis, with emphasis on the role of DNA damage and repair. During the last few years, we have developed ultra-sensitive and highly specific mass spectrometry methods for measuring the DNA and hemoglobin adducts of vinyl chloride, crotonaldehyde, ethylene oxide, propylene oxide, styrene oxide, butadiene, malondialdehyde, cis-platin and O6-methyldeoxy-guanosine, as well as slotblot methods for AP sites and oxidative DNA damage. These methods have been applied to understanding critical mechanisms in carcinogenesis, as well as undertaking molecular epidemiology studies of workers in the butadiene and reinforced plastics industries. We are also examining changes in gene expression associated with oxidative stress and environmental chemical exposure.
]]>Website: http://pharmacy.unc.edu/Directory/tropsha
Email: alex_tropsha@unc.edu
Voice: (919) 966-2955
The major area of our research is Biomolecular Informatics, which implies understanding relationships between molecular structures (organic or macromolecular) and their properties (activity or function). We are interested in building validated and predictive quantitative models that relate molecular structure and its biological function using statistical and machine learning approaches. We exploit these models to make verifiable predictions about putative function of untested molecules.
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