Website: http://www.unc.edu/~lmball/
Email: lmball@unc.edu
Voice: (919) 966-7306
]]>Website: http://www.niehs.nih.gov/about/od/director/index.cfm
Email: birnbaumls@niehs.nih.gov
Voice: (919) 541-3201
]]>Website: http://www.med.unc.edu/pathology/faculty/biosketch-of-dr-thomas-bouldin
Email: tbouldin@med.unc.edu
Voice: (919) 843-1074
]]>Email: cannon1@niehs.nih.gov
The Cancer Biology Group at NIEHS focuses on early events in skin tumor development using a transgenic mouse model (TgAC). This model possesses a v-Ha-ras transgene under the regulation of a fetal globin promotor integrated at an ectopic site which confers a unique phenotype of inducible skin papillomas with a high rate of progression to invasive squamous and spindle cell neoplasms. The goals of our studies are to identify and characterize: 1) The cellular origin of the tumors and 2) critical genes which are involved in ras-mediated tumor induction and progression. Conventional cancer therapies have until recently depended on treatment of late stages of tumor growth and involved non-specific mechanisms of cellular injury. By focusing on understanding early events in tumor induction we hope to gain insights into targets for intervention that can more specifically inhibit cancer cell growth.
]]>Website: http://www.med.unc.edu/pathology/faculty/biosketch-of-dr-william-coleman
Email: william.coleman@pathology.unc.edu
Voice: (919) 966-2699
The research in our laboratory involves several major projects related to the molecular pathogenesis of human cancer and investigations related to the biology of liver stem-like progenitor cells, including (i) characterization of human liver tumor suppressor genes, (ii) analysis of genetic determinants of breast cancer, (iii) investigation of mechanisms governing aberrant DNA methylation in breast cancer, (iv) liver progenitor cell responses after toxic liver injury, and (v) transplantation of liver stem-like progenitor cells for correction of genetic liver disease.
]]>Website: http://www.med.unc.edu/pathology/faculty/biosketch-of-dr-marila-cordeiro-stone
Email: marila_cordeiro-stone@med.unc.edu
Voice: (919) 966-1396
]]>Website: http://www.niehs.nih.gov/research/atniehs/labs/tob/experimental/index.cfm
Email: devitom@niehs.nih.gov
Voice: (919) 541-4142
]]>Email: devlin.robert@epa.gov
Voice: (919) 966-6256
]]>Website: http://www.sph.unc.edu/?option=com_profiles&Itemid=1891&profileAction=ProfDetail&pid=704287000
Email: avram_gold@unc.edu
Voice: (919) 966-7304
]]>Email: ramabhadran.ram@epa.gov
Voice: (919) 541-3558
1) Using cellular stress signaling pathways to develop in vitro assays in human cells to rapidly ascertain the toxic potential of a wide range of environmental compounds including nanoparticles used in commerce. This research draws extensively on signaling pathways in cells and on high throughput methods including robotics and developing methods for data analysis. 2) Design molecular studies to ascertain the mode of action of environmental compounds of potential concern. This research employs the use of gene over expression and suppression (RNAi) in established and primary cell cultures. 3) Development of alternate species assays for in vivo rapid screening of environmental compounds using normal and transgenic zebrafish.
]]>Website: http://www.med.unc.edu/cellbio/faculty-research/sulik
Email: mouse@med.unc.edu
Voice: (919) 966-3208
Research in my laboratory is directed toward achieving a better understanding of the mechanisms and pathogenesis associated with a variety of environmentally induced or genetically based birth defects. This information is then applied to development of preventative/ameliorative measures relative to these defects. Our interest in modeling human genetic malformation syndromes and opportunities for collaborative efforts with molecular geneticists who have produced transgenic mice and mice with targeted gene modification have proven productive in our attempt to better understand the developmental basis for a variety of malformations of the brain including anencephaly, holoprosencephaly, and hydrocephaly. Regarding teratogen-induced birth defects, our major emphasis is on Fetal Alcohol Spectrum Disorders (FASD). Currently, high resolution magnetic resonance imaging (MRI) is being utilized to identify, characterize, and correlate the craniofacial, ocular, otic and CNS dysmorphology that results from prenatal ethanol exposure at specific stages of embryogenesis. These studies are designed to inform human clinical research and to expand the diagnostic criteria for prenatal alcohol exposure.
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