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Please note that the fees were changed on 2020.04.07.

Billing Fees

 

Name Internal Rate External Rate (please use
Science Exchange*)
Rate 1

experimental

$222 $345
Rate 2 $5,265 (per virus, per calendar year) $8,187
Rate 3 Viral Load (clinical) $230 (5 targets) $358
Rate 4 96 Primer array $1,658 (per batch of 4) $2,578
Rate 5 96 Primer set-up $3,827 (per array per calendar year) $5,951
Rate 6 $2,385 (per batch of 4) $3,709
Rate 7 $1,235 $1,921
Rate 8 $1,666 (per type of array) $2,590
Rate 9 / 13 Consultation $128 (~ $3,609 bioinformatics cost per sequencing project) $198 (~ $5,611 bioinformatics cost per sequencing project)
Rate 16, 15, 18 Seq. Library

(S5)
RNA: $350,

DNA: $269,

targeted (Ampliseq): $430

RNA: $544

DNA: $418

targeted: $668

Rate 19
(S5)
$1,818 per run (up to 8 multiplexed samples; or 48 for Microbiome)

Exome: $1,707 per sample (Rate 17)

$2,827 per run

Exome: $2,629 per sample (Rate 17)

(Rate 1) Viral load experimental (batch of 8):

The rate is per sample (batch of 8) per real-time PCR primer. The core does not accept single samples for this rate. This rate will determine virus loads, i.e. how much virus is in a supplied sample. The Core will provide a central service for quantitative single viral load determination (using real-time qPCR) of experimental samples, this includes running quality control of reagents. This excludes clinical material.

(Rate 2) Viral load annual set-up:

The rate is annually per target. This is a set-up fee, which is due annually for each new virus that the core will quantitate using rate 1. This set-up fee covers necessary regulatory, quality control, validation, and data set-up work. The Vironomics Core Facility will maintain an infrastructure that is compliant with these regulations and perform the administrative action needed to be in compliance. These may differ depending on the particular virus.

(Rate 3) Viral Load (clinical):

The rate is per sample, which will be analyzed for at most 4 targets (or 1 target in quadruplicate). This rate will determine virus loads, i.e. how much virus is in a supplied sample. This rate covers sample genomic isolation, cDNA preparation if needed, and analysis of this sample with a single primer and control for sample integrity. The reporting and regulatory requirements are much more stringent for clinical material. Clinical samples require a heavy investment to conform with federal standards that apply to biosafety, GLP, HIPPA and GCLP regulations. Note that the core does not accept patient samples, or any samples that can be linked to individual persons. All samples must be de-identified.

(Rate 4) 96 primer array (batch of 4):

The rate is per sample and provides for the analysis of this sample, in duplicate, with 96 different primers using in-house developed arrays (IP contributed by the Dittmer group). This rate only applies to non-clinical samples. The Core Facility will provide microarray services based on real-time QPCR. At this point, the core is offering the following UNC-developed arrays: KSHV, EBV, HCMV, HSV-1, HSV-2, RRV, Viral Load, NFkB, Pre-miRNA, and TP52-response. This technology is more sensitive, more specific and targeted to specific needs of the user. This is in contrast to hybridization-based microarray facilities, which only use commercial assays to profile gene expression.

(Rate 5) 96 primer annual array set up:

The rate is annually per sample array. This is a set-up fee, which is due annually for each new virus that the core will quantitate using rate 4. The rate only applies to non-clinical samples. This set-up fee covers necessary regulatory, quality control, validation, and data set-up work. The Vironomics Core Facility will maintain an infrastructure that is compliant with these regulations and perform the administrative action needed to be in compliance. These may differ depending on the particular array.

(Rate 6) 96 gene viral array (clinical, batch of 4):

The rate is per sample and provides for the sample genomic isolation, cDNA preparation, and analysis of this sample with 96 different primers using in-house developed arrays (IP contributed by the Dittmer group). This rate applies to clinical samples. Clinical samples require a heavy investment to conform with federal standards that apply to biosafety, GLP, HIPPA and GCLP regulations. Note that the core does not accept patient samples, or any samples that can be linked to individual persons. All samples must be de-identified.

(Rate 7) Commercial 96 (batch of 4) QCPR:

The rate is per batch of 4 samples. It uses a commercial reagents only rather than “Home-brew”. This rate only applies to non-clinical samples.

(Rate 8) Commercial 96 QCPR set up:

The rate is annually per sample per user of commercial arrays (rate 7). This set-up fee covers necessary regulatory, quality control, validation, robot and data set-up work. The Vironomics Core Facility will maintain an infrastructure that is compliant with these regulations and perform the administrative action needed to be in compliance. These may differ depending on the particular array.

(Rate 9) Consultation :

The rate is per hour. The core will provide data analysis for users, who do not wish to do it themselves. As with all core technologies, data analysis is not straightforward. We estimate $3,000 – 4,000 for the analysis of a multi-sample, multi-run sequencing experiment. Please ask for a custom estimate.

(Rate 15, 16, 17, 18) Sequencing Library (S5):

This rate is per sample preparation. This rate covers reagents, quality control checks, reagent procurement, equipment, bench space, and protocol assistance by staff. The Core will provide a central service for preparing samples for next generational sequencing. Rates differ depending on whether RNA or DNA is used as input and wether custom Ampliseq steps are required. We now also offer full human exome sequencing at $1,464 internally.

(Rate 19) Sequencing (including human exome):

This rate is per sequencing set-up and run. This rate includes Core staff setting-up and running the sequencer. This also includes reagents, reagent procurement, quality control checks, equipment, final data prepared by data analyst for customer, and two years of data storage. The Core will provide a central service for next generational sequencing. This is a variable rate that depends on the chip size, read-length, and material. 

(Rate other) on request:

A number of other service are available upon request, access to individual instruments is currently not possible. Please inquire

*ScienceExchange:

ScienceExchange is essentially an online service contractor that UNC has already set-up all the legal approvals with. Essentially, you will need to sign up for an account and will be paying ScienceExchange with whatever form you work out (plus a small fee), and ScienceExchange will pay us upon completion of the work. To begin, request a quote from us via https://www.scienceexchange.com/labs/vironomics-core . Once you request the quote, the lab manager will put in all the particular details for the services/quantity and you will accept the price quoted, then the Vironomics Core can accept samples. Shipping to the core can even be arranged directly via ScienceExchange (https://support.scienceexchange.com/hc/en-us/articles/204516837-How-do-I-use-the-shipping-feature-).

If ScienceExchange is not possible for your organization, we will need to set-up a legal contract.